Effects of Ionic Strength in the Medium on Sample Preconcentration Utilizing Nano-interstices between Self-Assembled Monolayers of Gold Nanoparticles

Nguyen, Ngoc-Viet; Wu, Jiansheng; Jen, Chun-Ping

doi:10.1007/s13206-018-2402-1

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…Salinization on the substrate surface was achieved using a (3-aminopropyl) triethoxysilane (APTES) mixture solution/H 2 O with a volume ratio of 1:1000 for 1 min. The APTES silanization and AuNPs self-assembly processes have been reported in our previous publications [34,38,39,40]. The obtained results indicated that the salinization duration of 1 min was suitable.…”

Section: Methodsmentioning

confidence: 54%

“…Gold beads with a mean diameter of 13 nm, purchased from Taiwan Advanced Nanotech Inc., were used in this study. The AuNPs diameter of 13 ± 1 nm was also chosen as the optimal size in our previous works for the protein preconcentrators [34,38,39,40]. Figure 3b–d shows the SAMs of AuNPs on a gold–glass substrate captured by a scanning electron microscopy system at magnifications of 20,000, 100,000, and 200,000 times, separately.…”

Section: Resultsmentioning

confidence: 99%

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Selective Detection of Human Lung Adenocarcinoma Cells Based on the Aptamer-Conjugated Self-Assembled Monolayer of Gold Nanoparticles

Nguyen

Jen

2019

Micromachines

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This study established a microfluidic chip for the capture of A549 human lung circulating tumor cells via the aptamer-conjugated self-assembled monolayer (SAM) of gold nanoparticles (AuNPs) in the channel. AuNPs are among the most attractive nanomaterials for the signal enhancement of biosensors owing to their unique chemical, physical, and mechanical properties. The microchip was fabricated using soft photolithography and casting and molding techniques. A self-assembly method was designed to attach AuNPs, cell-specific aptamers, and target cells onto the desired area (i.e., SAM area). In this study, the gold microelectrode configuration was characterized by fluorescence microscopy and impedance measurements to confirm the important modification steps. Subsequently, several investigations with the proposed assay were conducted with different cell samples to determine the specific binding ability of the device for A549 adenocarcinoma cancer cells. This work has ensured a simple, convenient, selective, and sensitive approach for the development of biosensors for lung cancer detection during the early stages.

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Section: Methodsmentioning

confidence: 54%

Section: Resultsmentioning

confidence: 99%

Selective Detection of Human Lung Adenocarcinoma Cells Based on the Aptamer-Conjugated Self-Assembled Monolayer of Gold Nanoparticles

Nguyen

Jen

2019

Micromachines

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“…This differs considerably from MAP containing nano-particles or micro-particles in solution where ionic strength must be considered. 16 In traditional MAPs, the CIP are embedded in a PDMS matrix and make up between 10 and 90 wt% of the mass of the entire mixture. 1 In this work, a much lower CIP concentration is employed, and the PDMS matrix is relatively soft (Shore A00 hardness).…”

Section: Sample Fabrication and Preparationmentioning

confidence: 99%

“…CIP SQ has a pure iron (Fe) content of up to 99,8%. This differs considerably from MAP containing nano‐particles or micro‐particles in solution where ionic strength must be considered . In traditional MAPs, the CIP are embedded in a PDMS matrix and make up between 10 and 90 wt% of the mass of the entire mixture .…”

Section: Sample Fabrication and Preparationmentioning

confidence: 99%

Infrared spectral analysis of low concentration magnetoactive polymers

Prem

Sindersberger

Monkman

2019

J of Applied Polymer Sci

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This work concerns an area of magnetoactive polymer (MAP) research seldom considered. Traditionally only MAP with high concentrations of magnetic filler (typically between 10 and 90 wt%) have been investigated. This article deals with a hitherto neglected aspect of research, namely MAP containing lower magnetic filler concentrations (1 to 3 wt%). This article utilizes a range of spectroscopic analysis methods (Raman and FTIR) and their applicability to MAP characterization at wavelengths ranging from 2.5 to 25 μm. Particular attention is paid to low carbonyl iron particle (CIP) concentrations in MAP for which the emergence of capillary doublets at a critical 2 wt% concentration is revealed. This results in measurable magnetic field-dependent changes in IR absorption at a wavelength of 4.255 μm together with a detectable CO 2 susceptibility.

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Enhanced immunoassay in a nanofluidic preconcentrator utilizing nano-interstices among self-assembled gold nanoparticles

Vu-Dinh

Tsao

Jen

2022

Biomed Microdevices

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Effects of Ionic Strength in the Medium on Sample Preconcentration Utilizing Nano-interstices between Self-Assembled Monolayers of Gold Nanoparticles

Cited by 7 publications

References 25 publications

Selective Detection of Human Lung Adenocarcinoma Cells Based on the Aptamer-Conjugated Self-Assembled Monolayer of Gold Nanoparticles

Selective Detection of Human Lung Adenocarcinoma Cells Based on the Aptamer-Conjugated Self-Assembled Monolayer of Gold Nanoparticles

Infrared spectral analysis of low concentration magnetoactive polymers

Enhanced immunoassay in a nanofluidic preconcentrator utilizing nano-interstices among self-assembled gold nanoparticles

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