Effects of Intrauterine Growth Restriction and Female Sex on Future Blood Pressure and Cardiovascular Disease

Davis, Gwendolyn K.; Newsome, Ashley D.; Ojeda, Norma B.; Alexander, Barbara T.

doi:10.1007/s11906-017-0712-7

Cited by 12 publications

(11 citation statements)

References 66 publications

(135 reference statements)

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“…43 The researchers suggest that female hormones could be relevant in the prevention of hypertension in pre-menopausal females. 41 In addition, hyperactivity of the rennin-angiotensin system and augmented oxidative stress, relevant features in hypertensive condition, are not changed in female offspring exposed to maternal protein malnutrition. 44,45 Please note that it is not the focus of this review to perform a comparison between genders in maternal malnutrition induced-hypertension models.…”

Section: Some Of the Initial Indications Of A Relationship Between Inmentioning

confidence: 99%

“…Previous findings relate that female offspring exposed to a nutritional insult during fetal life are resistant to the development of hypertension in young adulthood . The researchers suggest that female hormones could be relevant in the prevention of hypertension in pre‐menopausal females . In addition, hyperactivity of the rennin‐angiotensin system and augmented oxidative stress, relevant features in hypertensive condition, are not changed in female offspring exposed to maternal protein malnutrition .…”

Section: Historical Evidence Of Maternal Protein Restriction and Hypementioning

confidence: 99%

“…Please note that it is not the focus of this review to perform a comparison between genders in maternal malnutrition induced‐hypertension models. For better understanding of the evidence for sex differences in developmental programming of hypertension see Ojeda and colleagues (2008) and Davis and colleagues (2017) …”

Section: Historical Evidence Of Maternal Protein Restriction and Hypementioning

confidence: 99%

“…Interestingly, a number of experimental and clinical studies have related that onset of hypertension evidenced in offspring from maternal malnourished dams is sex-dependent. 14,41,42 Previous findings relate that female offspring exposed to a nutritional insult during fetal life are resistant to the development of hypertension in young adulthood. 43 The researchers suggest that female hormones could be relevant in the prevention of hypertension in pre-menopausal females.…”

Section: Some Of the Initial Indications Of A Relationship Between Inmentioning

confidence: 99%

“…For better understanding of the evidence for sex differences in developmental programming of hypertension see Ojeda and colleagues (2008) 46 and Davis and colleagues (2017). 41…”

Section: Some Of the Initial Indications Of A Relationship Between Inmentioning

confidence: 99%

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Maternal protein malnutrition induced‐hypertension: New evidence about the autonomic and respiratory dysfunctions and epigenetic mechanisms

Alves

Costa‐Silva

2017

Clin Exp Pharma Physio

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SummaryMaternal protein malnutrition during the critical stages of development (pregnancy, lactation and first infancy) can lead to adult hypertension. Studies have shown that renal and cardiovascular dysfunctions can be associated to the development of hypertension in humans and rats exposed to maternal protein malnutrition. The etiology of hypertension, however, includes a complex network involved in central and peripheral blood pressure control. Recently, the hyperactivity of the sympathetic nervous system in protein-restricted rats has been reported. Studies have shown that protein malnutrition during pregnancy and/or lactation alters blood pressure control through mechanisms that include central sympathetic-respiratory dysfunctions and epigenetic modifications, which may contribute to adult hypertension. Thus, this review will discuss the historical context, new evidences of neurogenic disruption in respiratorysympathetic activities and possible epigenetic mechanisms involved in maternal protein malnutrition induced-hypertension. K E Y W O R D Shypertension, malnutrition, phenotypic plasticity, sympathetic activity, ventilation | INTRODUCTIONArterial hypertension (AH) affects more than 1 billion people around the world and is a major risk factor for cardiovascular dysfunction, recognized as the main cause of morbidity and mortality. Because of the interaction between the sympathetic and respiratory nervous systems, growing evidence supports the notion that an increase in sympathetic and respiratory activities plays an important role in the development of hypertension. [8][9][10] This observation has prompted the development of several studies evaluating sympathetic and respiratory activities and sensitivity of peripheral and central chemoreceptors in various hypertension models. For example, in chronic intermittent hypoxia 8,11 in spontaneously hypertensive rats (SHR) 4 and in renovascular hypertension, 12 augmented sympathetic-respiratory activities and higher peripheral chemosensitivity were seen to be associated to hypertension.

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Section: Some Of the Initial Indications Of A Relationship Between Inmentioning

confidence: 99%

Section: Historical Evidence Of Maternal Protein Restriction and Hypementioning

confidence: 99%

Section: Historical Evidence Of Maternal Protein Restriction and Hypementioning

confidence: 99%

Section: Some Of the Initial Indications Of A Relationship Between Inmentioning

confidence: 99%

“…For better understanding of the evidence for sex differences in developmental programming of hypertension see Ojeda and colleagues (2008) 46 and Davis and colleagues (2017). 41…”

Section: Some Of the Initial Indications Of A Relationship Between Inmentioning

confidence: 99%

See 3 more Smart Citations