Effects of intranasal phototherapy on nasal mucosa in patients with allergic rhinitis

Koreck, Andrea; Szechenyi, A.; Mórocz, Mónika; Cîmpean, Anca Maria; Bella, Zs.; Garaczi, Edina; Raica, Marius; Olariu, Tudor Rareș; Raskó, István; Kemény, Lajos

doi:10.1016/j.jphotobiol.2007.09.013

Cited by 40 publications

(35 citation statements)

References 26 publications

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“…However, significant increases in the carcinogenic risks may not exist for all internal tissues compared with external tissues or for all UV wavelength regions compared with the UVA wavelength region. For example, another study examined a UVB‐emitting medical device, which is used to treat allergic rhinitis by causing immune suppression , and found nasal tissue cells have similar DNA damage repair rates as skin tissue cells suggesting a similar carcinogenic risk may exist between these tissues if a similar apoptotic death rate also exists. Thus, it is not clear which UV wavelengths cause which human tissues to be at a higher carcinogenic risk compared to skin.…”

Section: Introductionmentioning

confidence: 99%

UV Radiation Increases Carcinogenic Risks for Oral Tissues Compared to Skin

Agrawal

Shindell

Jordan

et al. 2013

Photochem & Photobiology

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People can expose their oral cavities to UV (290-400 nm) by simply opening their mouths while outdoors. They can also have their oral cavities exposed to UV indoors to different UV-emitting devices used for diagnoses, treatments and procedures like teeth whitening. Because the World Health Organization declared UV radiation as a complete human carcinogen in 2009, we asked if oral tissues are at a similar or higher carcinogenic risk compared to skin tissue. To understand the UVB (290-320 nm)-related carcinogenic risks to these tissues, we measured initial DNA damage in the form of cyclobutane pyrimidine dimers (CPD), the repair rate of CPD (24 h) and the number of apoptotic dead cells over time resulting from increasing doses of erythemally weighted UV radiation. We used commercially available 3D-engineered models of human skin (EpiDerm™), gingival (EpiGingival™) and oral (EpiOral™) tissues and developed an analytical approach for our tri-labeling fluorescent procedure to identify total DNA, CPD and apoptotic cells so we can simultaneously quantify DNA repair rates and dead cells. Both DNA repair and apoptotic cell numbers are significantly lower in oral cells compared with skin cells. The combined results suggest UVB-exposed oral tissues are at a significantly higher carcinogenic risk than skin tissues.

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Section: Introductionmentioning

confidence: 99%

UV Radiation Increases Carcinogenic Risks for Oral Tissues Compared to Skin

Agrawal

Shindell

Jordan

et al. 2013

Photochem & Photobiology

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“…® and the Twilight Teeth Platinum Accelerated Whitening System ® are commerically available and are used in combination with natural sunlight or sunlamps used for indoor tanning. Recent work from Bruzell and colleagues (19) examined the efficacy and risks of UV‐assisted tooth bleaching and found little, if any, enhanced effect by the UVR source, regardless of the chemical product used.…”

Section: Introductionmentioning

confidence: 99%

Nucleotide Excision Repair Is Reduced in Oral Epithelial Tissues Compared with Skin^‡

Mitchell

Paniker

Godar

2012

Photochem & Photobiology

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Ultraviolet radiation (UVR) exposure to internal tissues for diagnostic, therapeutic and cosmetic procedures has increased dramatically over the past decade. The greatest increase in UVR exposure of internal tissues occurs in the cosmetic industry where it is combined with oxidizing agents for teeth whitening, often in conjunction with indoor tanning. To address potential carcinogenic risks of these procedures, we analyzed the formation and repair of the DNA photoproducts associated with the signature mutations of UVR. Radioimmunoassay was used to quantify the induction and repair of cyclobutane pyrimidine dimers and pyrimidine(6-4)pyrimidone photoproducts in DNA purified from three reconstructed tissues, EpiDerm™, EpiGingival™, and EpiOral™ (MatTek Corp.). We observed comparable levels of DNA damage in all tissues immediately after UVR exposure. In contrast, repair was significantly reduced in both oral tissues compared to EpiDerm™. Our data suggest that UVR exposure of oral tissues can result in accumulation of DNA damage and increase the risk for carcinoma and melanoma of the mouth. Because NER is a broad-spectrum defense against DNA damage caused by a variety of agents in addition to UVR, our data suggest that the relatively low NER efficiency observed in oral tissues may have wide-ranging consequences in this highly exposed environment.

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“…They suggested that the UV-induced DNA damages responsing to respiratory epithelium is very similar to that of the human epidermis; and such nasal mucosa has the ability to efficiently repair UVB-induced DNA damage [18]. It was also reported in another study that markers of DNA damages elevated immediately after phototherapy were not presented within several days of treatment [19]. …”

Section: Discussionmentioning

confidence: 99%

Effects of Rhinophototherapy on Quality of Life in Persistant Allergic Rhinitis

Tatar

Korkmaz

Sürenoğlu

et al. 2013

Clin Exp Otorhinolaryngol

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ObjectivesTo investigate the effect of rhinophototherapy with medical therapy on quality of life in persistent allergic rhinitis.MethodsA prospective, randomized study was being performed between December 2009 and March 2010. The study included 65 patients with persistent allergic rhinitis. The diagnosis was confirmed with positive skin tests. All of the patients had house dust mite allergies. We divided the patients into two groups. First group (n=33) was given topical mometasone furoate 200 mcg/day and levocetirizine 5 mg/day for a month. Rhinophototherapy was applied with the same medical therapy to the second group (n=32), twice a week for three weeks continuously. Rhinophototherapy included visible light, ultraviolet A and ultraviolet B. We evaluated patients before the treatment, at the first month and at the third month after treatment with rhinoconjunctivitis quality of life questionnaire, nasal symptom scores and visual analogue scale (VAS) scores.ResultsImprovements of all variables of the quality of life questionnaire, nasal symptom scores and VAS were statistically significant in the second group both on the first and the third months when compared with the first group.ConclusionAllergic rhinitis is a social problem and impairs quality of life. Rhinophototherapy with medical therapy improves the quality of life in allergic rhinitis.

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Effects of intranasal phototherapy on nasal mucosa in patients with allergic rhinitis

Cited by 40 publications

References 26 publications

UV Radiation Increases Carcinogenic Risks for Oral Tissues Compared to Skin

UV Radiation Increases Carcinogenic Risks for Oral Tissues Compared to Skin

Nucleotide Excision Repair Is Reduced in Oral Epithelial Tissues Compared with Skin^‡

Effects of Rhinophototherapy on Quality of Life in Persistant Allergic Rhinitis

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Effects of intranasal phototherapy on nasal mucosa in patients with allergic rhinitis

Cited by 40 publications

References 26 publications

UV Radiation Increases Carcinogenic Risks for Oral Tissues Compared to Skin

UV Radiation Increases Carcinogenic Risks for Oral Tissues Compared to Skin

Nucleotide Excision Repair Is Reduced in Oral Epithelial Tissues Compared with Skin‡

Effects of Rhinophototherapy on Quality of Life in Persistant Allergic Rhinitis

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Product

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Nucleotide Excision Repair Is Reduced in Oral Epithelial Tissues Compared with Skin^‡