Effects of intrahippocampal injection of ghrelin on spatial memory in PTZ-induced seizures in male rats

Babri, Shirin; Amani, Mohammad; Mohaddes, Gisou; Mirzaei, Farhad; Mahmoudi, Fariba

doi:10.1016/j.npep.2013.05.005

Cited by 31 publications

(11 citation statements)

References 34 publications

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“…17 Intrahippocampal injection of ghrelin has been shown to have inhibitory effect against PTZinduced seizure that is probably mediated via brain GABAergic or neuropeptide-Y systems. [34][35][36] Previous studies have also demonstrated that ghrelin pretreatment diminishes oxidative stress and prevents the decrease in antioxidant enzyme activities in erythrocytes, liver and brain in a PTZ model of seizure. 37 In addition, ghrelin pretreatment reduced the level of lipid peroxidation and enhanced the antioxidant defense against exerciseinduced stress oxidative injury in rats' brain and liver.…”

Section: Discussionmentioning

confidence: 96%

Ghrelin Improves Antioxidant Defense in Blood and Brain in Normobaric Hypoxia in Adult Male Rats

Omrani¹,

Alipour²,

Mohaddes³

2015

Adv Pharm Bull

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Section: Discussionmentioning

confidence: 96%

Ghrelin Improves Antioxidant Defense in Blood and Brain in Normobaric Hypoxia in Adult Male Rats

Omrani¹,

Alipour²,

Mohaddes³

2015

Adv Pharm Bull

Self Cite

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“…Truly, injection of ghrelin appears to enhance the compactness of the synapse dendritic spines in the hypothalamus. According to both types of research by Babri, et al ghrelin can increase memory level [10]. Also, other studies by the simultaneous use of narcotics and ghrelin indicated that ghrelin can improve memory level [11,12].…”

Section: Resultsmentioning

confidence: 99%

“…Subsequently, ghrelin could be used to improve existing symptoms in multiple neurodegenerative and also neurological disorders as well as to make disease development slow. In the CA1 region of the hippocampus, ghrelin developed spatial memory and about the ghrelin secretion from the stomach through fasting, it can be theorized that ghrelin may have an ameliorating impact on learning and memory which exposed the enhancing the effect of higher doses of ghrelin on spatial memory in the PTZ-treated rats [10]. These findings indicate that the GHS-R1a blocking in the rat's brain using a selective antagonist impairs memory encoding and emphasis the idea of the signaling of endogenous ghrelin in the rat's brain is vital for memory attainment and merging [2].…”

Section: Discussionmentioning

confidence: 99%

Investigating the effect of ghrelin on improving memory and learning ability in animals: A systematic review

et al. 2021

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Ghrelin does an important role in neurological functions such as memory, learning, and cognition as well. There is some evidence that ghrelin can improve memory. This study aimed to evaluate the effects of ghrelin on rat memory. A systematic search was conducted to identify papers published by Iranian authors in the Web of Science, PubMed, Scopus, Embase, and Google Scholar electronic databases from January 2010 to December 2019 with the PRISMA statement. Totally, 547 animals were listed in our systematic review. All of the animals were male Wistar rats with a mean weight of 250±280 g. The Morris Water Behavior behavioral test and the passive avoidance task were performed to evaluate memory. Truly, injection of ghrelin appears to enhance the compactness of the synapse dendritic spines in the hypothalamus. These findings indicate that ghrelin has a prospective role to recover learning and memory ability in animal models, suggesting it as a candidate therapy for memory.

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“…It was also shown to exert anti-inflammatory effects in the kainic acid mouse model [10], and in the rat PTZ model [18]. Additionally, locally infused ghrelin appeared to dose-dependently improve spatial memory in PTZ-treated rats [19], which is interesting in light of co-morbidities associated with epilepsy.…”

Section: Introductionmentioning

confidence: 99%

Differential Effects of a Full and Biased Ghrelin Receptor Agonist in a Mouse Kindling Model

Buckinx

Herrewegen

Pierre

et al. 2019

IJMS

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The ghrelin system has received substantial recognition as a potential target for novel anti-seizure drugs. Ghrelin receptor (ghrelin-R) signaling is complex, involving Gαq/11, Gαi/o, Gα12/13, and β-arrestin pathways. In this study, we aimed to deepen our understanding regarding signaling pathways downstream the ghrelin-R responsible for mediating anticonvulsive effects in a kindling model. Mice were administered the proconvulsive dopamine 1 receptor-agonist, SKF81297, to gradually induce a kindled state. Prior to every SKF81297 injection, mice were treated with a ghrelin-R full agonist (JMV-1843), a Gαq and Gα12 biased ligand unable to recruit β-arrestin (YIL781), a ghrelin-R antagonist (JMV-2959), or saline. Mice treated with JMV-1843 had fewer and less severe seizures compared to saline-treated controls, while mice treated with YIL781 experienced longer and more severe seizures. JMV-2959 treatment did not lead to differences in seizure severity and number. Altogether, these results indicate that the Gαq or Gα12 signaling pathways are not responsible for mediating JMV-1843′s anticonvulsive effects and suggest a possible involvement of β-arrestin signaling in the anticonvulsive effects mediated by ghrelin-R modulation.

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Effects of intrahippocampal injection of ghrelin on spatial memory in PTZ-induced seizures in male rats

Cited by 31 publications

References 34 publications

Ghrelin Improves Antioxidant Defense in Blood and Brain in Normobaric Hypoxia in Adult Male Rats

Ghrelin Improves Antioxidant Defense in Blood and Brain in Normobaric Hypoxia in Adult Male Rats

Investigating the effect of ghrelin on improving memory and learning ability in animals: A systematic review

Differential Effects of a Full and Biased Ghrelin Receptor Agonist in a Mouse Kindling Model

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