Effects of intracerebroventricular ghrelin on food intake and Fos expression in the arcuate nucleus of the hypothalamus in female rats vary with estrous cycle phase

Sakurazawa, Nobuko; Mano-Otagiri, Asuka; Nemoto, Tetsuo; Shibasaki, Tamotsu

doi:10.1016/j.neulet.2013.02.006

Cited by 19 publications

(14 citation statements)

References 28 publications

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“…This suggests that the interaction of fasting and E2 differentially regulates Ghsr in the ARC. While Ghsr expression does not change during the estrous cycle in female rats, ghrelin’s effects on food intake are only found during the diestrus cycle, when E2 levels are lower (Sakurazawa et al, 2013). The differential effect on ghrelin sensitivity and Ghsr expression may be due, in part, to changes in expression of downstream effectors of GHSR signaling (e.g., Cpt1c, Foxo1 ) as we have found in the ARC and in NPY pools.…”

Section: Discussionmentioning

confidence: 99%

Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol

Yasrebi

Hsieh

Mamounis

et al. 2016

Molecular and Cellular Endocrinology

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Ghrelin’s receptor, growth hormone secretagogue receptor (GHSR), is highly expressed in the arcuate nucleus (ARC) and in neuropeptide Y (NPY) neurons. Fasting, diet-induced obesity (DIO), and 17β-estradiol (E2) influence ARC Ghsr expression. It is unknown if these effects occur in NPY neurons. Therefore, we examined the expression of Npy, Agrp, and GHSR signaling pathway genes after fasting, DIO, and E2 replacement in ARC and pools of NPY neurons. In males, fasting increased ARC Ghsr and NPY Foxo1 but decreased NPY Ucp2. In males, DIO decreased ARC and NPY Ghsr and Cpt1c. In fed females, E2 increased Agrp, Ghsr, Cpt1c, and Foxo1 in ARC. In NPY pools, E2 decreased Foxo1 in fed females but increased Foxo1 in fasted females. DIO in females suppressed Agrp and augmented Cpt1c in NPY neurons. In summary, genes involved in GHSR signaling are differentially regulated between the ARC and NPY neurons in a sex-dependent manner.

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Section: Discussionmentioning

confidence: 99%

Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol

Yasrebi

Hsieh

Mamounis

et al. 2016

Molecular and Cellular Endocrinology

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“…Previous studies have demonstrated that feeding varies across differing stages of the oestrous cycle in rodents, nonhuman primates and humans . The feeding response to hunger‐related hormones (including ghrelin) and neurosteroids also varies throughout different stages of the oestrous cycle in female rats . It is recommended that future studies continue to investigate the extent to which oestrous cycle phase and fluctuations in ovarian hormones might influence the satiety response to oxytocin in female animal models.…”

Section: Resultsmentioning

confidence: 99%

A systematic review and quantitative meta‐analysis of the effects of oxytocin on feeding

Leslie

Silva

Paloyelis

et al. 2018

J Neuroendocrinology

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Oxytocin reduces energy intake when administered as a single dose. Oxytocin can inhibit feeding over two- to three-week periods in rodent models. These effects typically do not persist beyond the third week of treatment. The anorexigenic effect of oxytocin is moderated by pregnant status, dose, method of administration, and diet composition. This article is protected by copyright. All rights reserved.

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“…What it is well described so far is that estrogens in the CNS increase the sensitivity to anorexigenic molecules such as leptin, released by adipocytes 49–52 , cholecystokinin (CCK), produced by small intestine 53, 54 and insulin, synthesized by the pancreas 51, 52 and, at the same time, decrease the response to the orexigenic peptide ghrelin from the gastro-intestinal tract 55, 56 .…”

Section: Discussionmentioning

confidence: 99%

Liver ERα regulates AgRP neuronal activity in the arcuate nucleus of female mice

Benedusi

Torre

Mitro

et al. 2017

Sci Rep

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Recent work revealed the major role played by liver Estrogen Receptor α (ERα) in the regulation of metabolic and reproductive functions. By using mutant mice with liver-specific ablation of Erα, we here demonstrate that the hepatic ERα is essential for the modulation of the activity of Agouti Related Protein (AgRP) neurons in relation to the reproductive cycle and diet. Our results suggest that the alterations of hepatic lipid metabolism due to the lack of liver ERα activity are responsible for a neuroinflammatory status that induces refractoriness of AgRP neurons to reproductive and dietary stimuli. The study therefore points to the liver ERα as a necessary sensor for the coordination of systemic energy metabolism and reproductive functions.

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Effects of intracerebroventricular ghrelin on food intake and Fos expression in the arcuate nucleus of the hypothalamus in female rats vary with estrous cycle phase

Cited by 19 publications

References 28 publications

Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol

Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol

A systematic review and quantitative meta‐analysis of the effects of oxytocin on feeding

Liver ERα regulates AgRP neuronal activity in the arcuate nucleus of female mice

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