A systematic review and quantitative meta‐analysis of the effects of oxytocin on feeding

Leslie, Monica; Silva, Paulo; Paloyelis, Yannis; Blevins, James E.; Treasure, Janet

doi:10.1111/jne.12584

Cited by 52 publications

(46 citation statements)

References 79 publications

(119 reference statements)

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“…[161][162][163] The anorexigenic effect of oxytocin has been shown to be stronger in diet-induced obese rodents. 161 SNPs of the gene encoding the oxytocin receptor have been shown to be associated with eating disorders including anorexia nervosa and bulimia nervosa. 161 SNPs of the gene encoding the oxytocin receptor have been shown to be associated with eating disorders including anorexia nervosa and bulimia nervosa.…”

Section: Roles Of Oxytocin In the Control Of Food Intakementioning

confidence: 99%

“…130,146,159,160 Oxytocin administration has been shown to reduce food intake in laboratory animals and humans. [161][162][163] The anorexigenic effect of oxytocin has been shown to be stronger in diet-induced obese rodents. 164 However, a meta-analysis revealed that the anorexigenic effect of oxytocin administration is not statistically significant in humans.…”

Section: Roles Of Oxytocin In the Control Of Food Intakementioning

confidence: 99%

“…164 However, a meta-analysis revealed that the anorexigenic effect of oxytocin administration is not statistically significant in humans. 161 SNPs of the gene encoding the oxytocin receptor have been shown to be associated with eating disorders including anorexia nervosa and bulimia nervosa. 165 On the other hand, although oxytocin receptor-deficient male mice show late-onset mild obesity, 166 it has been reported that oxytocin receptor deficiency, 166 chemogenetic inhibition of hypothalamic paraventricular oxytocin neurones, 167 genetically targeted ablation of oxytocin neurones 152 and destruction of hypothalamic paraventricular oxytocin neurones 150 do not significantly change the total amounts of food intake in mice.…”

Section: Roles Of Oxytocin In the Control Of Food Intakementioning

confidence: 99%

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Role of oxytocin in the control of stress and food intake

Onaka

Takayanagi

2019

J Neuroendocrinology

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Oxytocin neurones in the hypothalamus are activated by stressful stimuli and food intake. The oxytocin receptor is located in various brain regions, including the sensory information‐processing cerebral cortex; the cognitive information‐processing prefrontal cortex; reward‐related regions such as the ventral tegmental areas, nucleus accumbens and raphe nucleus; stress‐related areas such as the amygdala, hippocampus, ventrolateral part of the ventromedial hypothalamus and ventrolateral periaqueductal gray; homeostasis‐controlling hypothalamus; and the dorsal motor complex controlling intestinal functions. Oxytocin affects behavioural and neuroendocrine stress responses and terminates food intake by acting on the metabolic or nutritional homeostasis system, modulating emotional processing, reducing reward values of food intake, and facilitating sensory and cognitive processing via multiple brain regions. Oxytocin also plays a role in interactive actions between stress and food intake and contributes to adaptive active coping behaviours.

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Section: Roles Of Oxytocin In the Control Of Food Intakementioning

confidence: 99%

Section: Roles Of Oxytocin In the Control Of Food Intakementioning

confidence: 99%

Section: Roles Of Oxytocin In the Control Of Food Intakementioning

confidence: 99%

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Role of oxytocin in the control of stress and food intake

Onaka

Takayanagi

2019

J Neuroendocrinology

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“…The oxytocin (OT) system has been a promising research area in translational neuroscience over the past decade (1,2). Robust evidence from studies in preclinical models has demonstrated the importance of the central OT system in the development (3) and regulation of complex social behaviours (4,5), the modulation of pain processing (6), feeding behaviour (7) and neuroinflammation after brain ischemia (8). Harnessing the central OT system has been identified as a potential strategy for the development of targeted pharmacological interventions to help to improve outcome in several conditions for which efficacious treatments do not currently exist (e.g autism spectrum disorder (9), schizophrenia (10), migraine (11), stroke (8), obesity (12), Prader-Willi (13)).…”

mentioning

confidence: 99%

Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans

Martins

Mazibuko

Zelaya

et al. 2019

Preprint

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Do nose-to-brain pathways mediate the effects of peptides such as oxytocin (OT) on brain physiology when delivered intranasally? We addressed this question by contrasting two methods of intranasal administration (a standard nasal spray, and a nebuliser expected to improve OT deposition in nasal areas putatively involved in direct nose-to-brain transport) to intravenous administration in terms of effects on regional cerebral blood flow during two hours post-dosing.We demonstrate that OT-induced decreases in amygdala perfusion, a key hub of the OT central circuitry, are explained entirely by OT increases in systemic circulation following both intranasal and intravenous OT administration. Yet we also provide robust evidence confirming the validity of the intranasal route to target specific brain regions. Our work has important translational implications and demonstrates the need to carefully consider the method of administration in our efforts to engage specific central oxytocinergic targets for the treatment of neuropsychiatric disorders.

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“…One such potential treatment is intranasal oxytocin (OT) [27][28][29] . Support for the implication of OT in binge eating comes from animal 30 and human studies 31,32 demonstrating that OT suppresses eating, including hedonic eating in men 33 . Some small clinical studies have also shown that intranasal OT (40IU) reduces caloric intake 34 and decreases vigilance towards angry faces 35 in women with BN.…”

Section: Introductionmentioning

confidence: 99%

Investigating resting brain perfusion abnormalities and target-engagement by intranasal oxytocin in women with bulimia nervosa and binge-eating disorder and healthy controls

Martins¹,

Leslie²,

Rodan³

et al. 2020

Preprint

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Advances in the treatment of bulimia nervosa and binge eating disorder (BN/BED) have been marred by our limited understanding of the underpinning neurobiology. Here we measured regional cerebral blood flow (rCBF) to map resting perfusion abnormalities in women with BN/BED compared to healthy controls and investigate if intranasal oxytocin (OT), proposed as a potential treatment, can restore perfusion in disorder-related brain circuits. Twenty-four women with BN/BED and 23 healthy women participated in a randomised, double-blind, crossover, placebo-controlled study. We used arterial spin labelling MRI to measure rCBF and the effects of an acute dose of intranasal OT (40IU) or placebo over 18-26 minutes post-dosing, as we have previously shown robust OT-induced changes in resting rCBF in men 15-36min post-dosing. We tested for effects of treatment, diagnosis and their interaction on extracted rCBF values in anatomical regions-of-interest previously implicated in BN/BED by other neuroimaging modalities, and conducted exploratory whole-brain analyses to investigate previously unidentified brain regions. We demonstrated that women with BN/BED presented increased resting rCBF in key neural circuits previously implicated in BN/BED pathophysiology, namely the medial prefrontal and orbitofrontal cortices, anterior cingulate gyrus, posterior insula and middle/inferior temporal gyri bilaterally. Hyperperfusion in these areas specifically correlated with eating symptoms severity in patients. Our data did not support a normalizing effect of 40IU intranasal OT on perfusion abnormalities in these patients 18-26 minutes post-dosing. Our findings enhance our understanding of resting brain abnormalities in BN/BED and identify resting rCBF as a non-invasive potential biomarker for disease-related changes and treatment monitoring.

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A systematic review and quantitative meta‐analysis of the effects of oxytocin on feeding

Cited by 52 publications

References 79 publications

Role of oxytocin in the control of stress and food intake

Role of oxytocin in the control of stress and food intake

Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans

Investigating resting brain perfusion abnormalities and target-engagement by intranasal oxytocin in women with bulimia nervosa and binge-eating disorder and healthy controls

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