Effects of interrupting prolonged sitting on postprandial glycemia and insulin responses: A network meta-analysis

Quan, Minghui; Xun, Pengcheng; Hua, Wu; Wang, Jing; Cheng, Wei; Cao, Meng; Zhou, Tang; Huang, Tao; Gao, Zan; Chen, Peijie

doi:10.1016/j.jshs.2020.12.006

Cited by 19 publications

(14 citation statements)

References 58 publications

(123 reference statements)

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“…Nonetheless, our findings suggest that sedentary breaks every 60 min may not be an efficacious frequency for the lowering of glucose at a given sedentary break duration of 1 or 5 min; albeit further research is needed to determine if a higher sedentary break duration (i.e., 10 min) or intensity (i.e., moderate or vigorous) would yield stronger effects at this frequency. Our findings are consistent with a recent network meta-analysis, which identified a sedentary break frequency of every 20 to 30 min as the optimal frequency for reducing postprandial glycemic responses (35). We extend upon this work and confirm the efficacy of the every 30 min sedentary break frequency within the context of a single study, which permits direct comparisons of dose under identical controlled laboratory settings.…”

Section: Discussionsupporting

confidence: 92%

Breaking Up Prolonged Sitting to Improve Cardiometabolic Risk: Dose–Response Analysis of a Randomized Crossover Trial

Duran

Friel

Serafini

et al. 2023

Medicine &Amp; Science in Sports &Amp; Exercise

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PurposeSedentary time is ubiquitous in developed nations and is associated with deleterious health outcomes. Physical activity guidelines recommend reductions in sedentary time; however, quantitative guidelines that inform how often and how long sedentary time should be interrupted have not been provided. The purpose of this study was to examine the acute effects of multiple doses of a sedentary break intervention on cardiometabolic risk factors, concurrently evaluating efficacy of varying frequencies and durations of sedentary breaks.MethodsIn a randomized crossover study, middle- and older-age adults (n = 11) completed the following 8-h conditions on five separate days: 1 uninterrupted sedentary (control) condition and four acute (experimental) trials that entailed different sedentary break frequency/duration combinations: every 30 min for 1 min, every 30 min for 5 min, every 60 min for 1 min, and every 60 min for 5 min. Sedentary breaks entailed light-intensity walking. Glucose and blood pressure (BP) were measured every 15 and 60 min, respectively.ResultsCompared with control, glucose incremental area under the curve was significantly attenuated only for the every 30 min for 5-min dose (−11.8[4.7]; P = 0.017). All sedentary break doses yielded significant net decreases in systolic BP from baseline compared with control (P < 0.05). The largest reductions in systolic BP were observed for the every 60 min for 1 min (−5.2 [1.4] mm Hg) and every 30 min for 5 min (−4.3[1.4] mm Hg) doses.ConclusionsThe present study provides important information concerning efficacious sedentary break doses. Higher-frequency and longer-duration breaks (every 30 min for 5 min) should be considered when targeting glycemic responses, whereas lower doses may be sufficient for BP lowering.

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Section: Discussionsupporting

confidence: 92%

Breaking Up Prolonged Sitting to Improve Cardiometabolic Risk: Dose–Response Analysis of a Randomized Crossover Trial

Duran

Friel

Serafini

et al. 2023

Medicine &Amp; Science in Sports &Amp; Exercise

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“…Recent meta‐analyses have attempted to assess the effectiveness of interrupting prolonged sitting to lower postprandial glucose and insulin responses (26‐28). The effectiveness of physical activity breaks to lower postprandial glucose iAUC in people with obesity, impaired fasting glucose, or type 2 diabetes greatly varied across 24 studies presented within a meta‐analysis by Loh et al (26).…”

Section: Discussionmentioning

confidence: 99%

Leg Fidgeting During Prolonged Sitting Improves Postprandial Glycemic Control in People with Obesity

Pettit‐Mee

Ready

Padilla

et al. 2021

Obesity

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ObjectiveStudies have shown that fidgeting augments metabolic demand and increases blood flow to the moving limbs, whereas prolonged sitting suppresses these factors and exacerbates postprandial glucose excursions. Therefore, the hypothesis of this study was that leg fidgeting during prolonged sitting would improve postprandial glycemic control.MethodsAdults with obesity (n = 20) participated in a randomized crossover trial in which blood glucose and insulin concentrations were measured during a 3‐hour sitting period following the ingestion of a glucose load (75 g). During sitting, participants either remained stationary or intermittently fidgeted both legs (2.5 minutes off and 2.5 minutes on). Accelerometer counts, oxygen consumption, and popliteal‐artery blood flow were also measured during the sitting period.ResultsAs expected, fidgeting increased accelerometer counts (P < 0.01), oxygen consumption (P < 0.01), and blood flow through the popliteal artery (P < 0.05). Notably, fidgeting lowered both glucose (P < 0.01) and insulin (P < 0.05) total area under the curve (AUC) and glucose incremental AUC (P < 0.05). Additionally, there was a strong negative correlation between fidgeting‐induced increases in blood flow and reduced postprandial glucose AUC within the first hour (r = −0.569, P < 0.01).ConclusionsLeg fidgeting is a simple, light‐intensity physical activity that enhances limb blood flow and can be incorporated during prolonged sitting to improve postprandial glycemic control in people with obesity.

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“…Even a simple standing interrupting behavior could induce beneficial metabolic changes, such as making insulin, total cholesterol content and fast blood sugar in an inevitable decline ( 36 ). Besides, findings were also observed that ST Breaks times could significantly improve the body's glucose metabolism with no increase in total energy intake among overweight and obese children ( 37 ), and positively reduce postprandial hypoglycemia and insulin responses among adults ( 38 ). The result seems to provide an effective way to improve the overweight state of children and adolescents.…”

Section: Discussionmentioning

confidence: 98%

The Association of Different Sedentary Patterns and Health-Related Physical Fitness in Pre-schoolers

Lü

Zhou

et al. 2022

Front. Pediatr.

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Background: The results of sedentary time (ST) and health-related physical fitness (HPF) are not completely consistent and the studies concentrated on pre-schoolers are very limited.Methods: We measured ST and ST patterns (ST Bouts time, ST Breaks times) by accelerometer. The health-related physical fitness T-score (HPFT) was calculated by five indexes: height-weight standard score, 20 m shuttle-run test, grip strength, standing long jump and 2 × 10 m shuttle-run test.Results: We included 375 pre-schoolers (211 boys, 164 girls) in the final analysis. The total ST and ST Bouts times negatively correlated with HPFT in pre-schoolers. HPFT reduced by 1.69 and 0.70 points per 10 min increased in total ST and ST Bouts times, respectively. HPFT of the highest quartile group reduced by 9.85 points in total ST, and 10.54 points in ST Bouts time compared with the lowest quartile group. However, the HPFT increased by 0.09 points per 10 times increased in ST Breaks times; the HPFT increased by 16.21 and 15.59 points when moderate to vigorous physical activity (MVPA) replaced total ST and ST Bouts time.Conclusions: HPF negatively correlated with the Total ST and ST Bouts times, but positively correlated with ST Breaks times; and HPF significantly improved when MVPA replaced ST in pre-schoolers.

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Effects of interrupting prolonged sitting on postprandial glycemia and insulin responses: A network meta-analysis

Cited by 19 publications

References 58 publications

Breaking Up Prolonged Sitting to Improve Cardiometabolic Risk: Dose–Response Analysis of a Randomized Crossover Trial

Breaking Up Prolonged Sitting to Improve Cardiometabolic Risk: Dose–Response Analysis of a Randomized Crossover Trial

Leg Fidgeting During Prolonged Sitting Improves Postprandial Glycemic Control in People with Obesity

The Association of Different Sedentary Patterns and Health-Related Physical Fitness in Pre-schoolers

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