Effects of Interleukin-1 on Sexual Attractivity in a Model of Sickness Behavior

Avitsur, Ronit; Cohen, Eran; Yirmiya, Raz

doi:10.1016/s0031-9384(97)00381-8

Cited by 54 publications

(34 citation statements)

References 26 publications

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“…It is unclear whether the cytokine-induced effects of ACTH on HPA axis function and subsequent release of corticosterone are dependent on the sex steroid environment. Previous studies in rats and mice have indicated that females may be more sensitive to the effects of endotoxin on the production of corticosterone [5,25]. It remains unknown whether this is also true in prairie voles, and should be investigated in future studies.…”

Section: Discussionmentioning

confidence: 94%

“…The use of a nonreplicating pathogen, such as LPS, eliminates the possibility of pathogen manipulation of host behavior, and suggests that the changes in social behavior observed are hostmediated behavioral modifications [10]. These results also diminish the role of lethargy or decreased sexual motivation that have been factors in previous studies of partner preference in nonmonogamous species such as rats and mice [5,8]. It is unclear whether the cytokine-induced effects of ACTH on HPA axis function and subsequent release of corticosterone are dependent on the sex steroid environment.…”

Section: Discussionmentioning

confidence: 99%

“…Males prefer intact over castrated females in preference tests, regardless of whether they have been exposed to IL-1 ␤ or saline [8]. Additionally, when healthy animals are given a choice between healthy or infected conspecifics, healthy males prefer saline-injected females over infected females in preference tests, whereas healthy females do not distinguish between infected and healthy males [5]. Alternatively, sex differences may exist in sickness behaviors such as lethargy or sexual motivation, and thus obscure mate preferences.…”

Section: Introductionmentioning

confidence: 98%

“…Several studies have demonstrated that bacterial infection may either inhibit or facilitate mating [5][6][7][8]; however, the proximate mechanism underlying the change in mating behavior among infected animals remain unspecified. IL-1 ␤ secretion during an immune response may decrease sexual motivation by reducing sex steroid concentrations.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Lipopolysaccharide facilitates partner preference behaviors in female prairie voles

DeVries

et al. 1999

Physiology & Behavior

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Lipopolysaccharide facilitates partner preference behaviors in female prairie voles

DeVries

et al. 1999

Physiology & Behavior

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“…Peripheral injections (i.p.) with LPS or IL-1 decreases the capability of treated female rats to arouse sexual motivation in a potential mate [133,134]. Suppression of sexual attractiveness in male rats needs much higher dose IL-1 (20 µg/kg) in comparison with females (5 µg/ kg).…”

Section: Breeding After Recovery Versus Breeding Before Deathmentioning

confidence: 99%

The Role of the Immune System in Behavioral Strategies of Reproduction

Мошкин

Gerlinskaya

Evsikov

2000

Journal of Reproduction and Development

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Abstract. Since both reproduction and immunocompetence are costly, the negative reciprocal relationships between these functions were found in many species. Due to reproductive immunosuppression, some fraction of seasonally breeding populations of small mammals reproduces in the first breeding season, while others reproduce in the next one. Elevation of breeding efforts under the increased risk of mortality and the reproductive delay until recovery are the polar variants of mating behavior of parasitized individuals. However the parasite-induced changes of odor, visual or acoustic signals limit the mating success of the infected hosts. The direct influence of the immune system, regularly activated by infections, to chemicals signals can be answer to the question: why these signals are honest? Decrease of a strange infection risk by kin breeding can be a satisfactory strategy of an isolated population. Nevertheless, many species follow the inbreeding avoidance strategy, where the major histocompatibility complex (MHC) genes play key role in kin recognition. The advantage of MHC heterozygosity was found at the all steps of the breeding cycle; including mating choice, fertilization, pre-and postnatal development. So, the relationships between immune system and neuroendocrine regulation of behavior give proximate explanations of the evolutionary stable strategies of breeding behavior.

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Human sickness behavior: Ultimate and proximate explanations

Shattuck

Muehlenbein

2015

American J Phys Anthropol

126

103

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Sickness behavior, a coordinated set of behavioral changes in response to infection, lies at the intersection of immunology, endocrinology, and evolutionary biology. Sickness behavior is elicited by pro-inflammatory cytokines, is thought to be an adaptive means of redirecting energy away from disadvantageous behaviors and toward mounting an effective immune response, and may be modulated by hormones, including testosterone and oxytocin. Research on sickness behavior in humans has lagged behind non-human animal research due to methodological complexities. Here we review what is known about sickness behavior in humans, the effects of various hormones on sickness behavior, the possible role of cytokine gene variation in influencing sickness behavior responses, and the ways in which culture and gender norms could similarly influence these behavioral changes. We also propose methodologies for advancing further studies of sickness behavior in humans.

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Effects of Interleukin-1 on Sexual Attractivity in a Model of Sickness Behavior

Cited by 54 publications

References 26 publications

Lipopolysaccharide facilitates partner preference behaviors in female prairie voles

Lipopolysaccharide facilitates partner preference behaviors in female prairie voles

The Role of the Immune System in Behavioral Strategies of Reproduction

Human sickness behavior: Ultimate and proximate explanations

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