Effects of Interaction with Surfactants, Adsorbents, and Other Substances on the Permeation of Chlorpromazine through a Dimethyl Polysiloxane Membrane

Drug Permeation through Membranes I: Effect of Various Substances on Amobarbital Permeation through Polydimethylsiloxane

“…Filler adds to the difficulty of membrane characterization and may lead to variation in the coefficient of permeability between different specimens of polydimethylsiloxane. Drugs and drug interactions studied by this technique include barbiturates, phenylalkylamines (9), aminophenones (14, 15), chlorpromazine (16), and various organic molecules (17). This paper reports the effect of typical excipients, endogenous substances, adsorbents, emulsifiers, and foods on the permeation of amobarbital through polydimethylsiloxane and rat intestinal membranes.…”

Drug permeation through membranes V: Interaction of diazepam with common excipients

“…Concentrations in excess of 70% I were necessary to produce appreciable enhancement of picrate-ion penetration, and such concentrations reduced the lag time from 5 to 2 hr (6). Subsequently it was demonstrated that the effect was not reversible (7).…”

“…Thus, the dialysis rate of prednisolone was found to depend upon the drug formulation (3). The effect of excipients and other materials on the permeation of amobarbital(41, phenylbutazone (5), chlordiazepoxide (6), and chlorpromazine (7) through polydimethylsiloxane also was reported.…”

Effect of pH on salicylic acid permeation through ethyl cellulose-PEG 4000 films

“…This report presents final evidence that EC-PEG membranes act as lipid-like barriers permeable mainly to unchanged drugs, hence permeability coefficients of ionizable drugs are dependent on the pH of the drug solution. In this respect, these mixed porous membranes resemble synthetic homogeneous barrier membranes, which have also been found to be selective in their transfer of ionizable drugs as a function of pH (Garrett & Chemburkar 1968;Nakano 1971;Lovering & Black 1974).…”