“…Filler adds to the difficulty of membrane characterization and may lead to variation in the coefficient of permeability between different specimens of polydimethylsiloxane. Drugs and drug interactions studied by this technique include barbiturates, phenylalkylamines (9), aminophenones (14, 15), chlorpromazine (16), and various organic molecules (17). This paper reports the effect of typical excipients, endogenous substances, adsorbents, emulsifiers, and foods on the permeation of amobarbital through polydimethylsiloxane and rat intestinal membranes.…”