Drug Permeation through Membranes I: Effect of Various Substances on Amobarbital Permeation through Polydimethylsiloxane

Drug Permeation through Membranes II: Simultaneous Dissolution and Permeation of Drug from Solid Dosage Forms

“…The permeability coefficients are, within experimental error, the same as those reported previously for amobarbital (6). The component of the lag time due to the nature of the drug and the membrane thickness, 13/60, in Eq.…”

“…of borate buffer in the diffusion cell. A tablet was put into the wire basket at time zero; at appropriate time intervals, the concentration of amobarbital in the diffusion cell was measured by UV spectroscopy at 240.5 nm., following the procedure already described (6). Tablet dissolution rates were measured directly by sampling the resin kettle at appropriate time intervals.…”

Combined Methodologies for Determining In Vitro Bioavailability of Drugs and Prediction of In Vivo Bioequivalence From Pharmaceutical Oral Formulations

“…Since the application of the Caco-2 model unfortunately presents many drawbacks, more innovative approaches, employing non-cellular biomimetic barriers, were developed for the same purpose ( Fischer et al, 2011b ; Fischer et al, 2012 ; Gantzsch et al, 2014 ). Other methods affected the development of dialysis-based dissolution/permeation models ( Lovering and Black, 1973 ; Blanquet et al, 2004 ). Unfortunately, even these methods are partially flawed, mainly due to the interaction of amphiphilic weak basic and acidic drugs with such biomimetic membranes ( Bibi et al, 2016 ).…”