2010
DOI: 10.1186/1749-8090-5-106
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Abstract: ObjectiveInosine, a break-down product of adenosine has been recently shown to exert inodilatory and anti-inflammatory properties. Furthermore inosine might be a key substrate of pharmacological post-conditioning. In the present pre-clinical study, we investigated the effects of inosine on cardiac function during reperfusion in an experimental model of cardioplegic arrest and extracorporal circulation.MethodsTwelve anesthetized dogs underwent hypothermic cardiopulmonary bypass. After 60 minutes of hypothermic … Show more

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Cited by 8 publications
(3 citation statements)
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References 29 publications
(30 reference statements)
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“…Inosine increases neuronal survival and neurite outgrowth in vitro , enhances axon regeneration and axonal sprouting after damage of the central nervous system, and promotes recovery in rodent models of stroke and focal brain trauma 1 2 3 . Administration of inosine improves myocardial function during acute left ventricular failure and protects myocardial and endothelial function after heart transplantation 4 5 . Inosine also augments mast-cell degradation, suppresses macrophage, lymphocyte and neutrophil activation, and attenuates inflammatory diseases 6 7 .…”
mentioning
confidence: 99%
“…Inosine increases neuronal survival and neurite outgrowth in vitro , enhances axon regeneration and axonal sprouting after damage of the central nervous system, and promotes recovery in rodent models of stroke and focal brain trauma 1 2 3 . Administration of inosine improves myocardial function during acute left ventricular failure and protects myocardial and endothelial function after heart transplantation 4 5 . Inosine also augments mast-cell degradation, suppresses macrophage, lymphocyte and neutrophil activation, and attenuates inflammatory diseases 6 7 .…”
mentioning
confidence: 99%
“…While the therapeutic utilization of adenosine as a hepatoprotective agent in vivo is difficult due to its short half-life and adverse cardiovascular side-effect profile, inosine may emerge as a potential candidate. Indeed, several recent studies have demonstrated that administration of inosine can be protective against various forms of ischemic conditions ( 7 10 ). The current results may provide a mechanistic explanation to the previously reported protective effect of inosine in vitro as an adjuvant to organ storage solutions ( 47 ) or in vivo as a protective agent in a rat model of hepatic reperfusion injury ( 48 ) and can stimulate further studies to explore whether inosine has the potential to improve cellular bioenergetics and to protect hepatocytes in various forms of liver injury, including various forms of warm ischemia or cold ischemia associated with liver transplantation.…”
Section: Discussionmentioning
confidence: 99%
“…For a long time inosine was considered to be an inactive metabolite. However, several studies have shown that it has immunomodulatory, neuroprotective, cardioprotective and cytoprotective effects ( 7 10 ). These effects have been attributed to several independent mechanisms.…”
Section: Introductionmentioning
confidence: 99%