2014
DOI: 10.1038/srep04199
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Abstract: Inosine, a breakdown product of adenosine, has recently been shown to exert immunomodulatory and neuroprotective effects. We show here that the oral administration of inosine has antidepressant-like effects in two animal models. Inosine significantly enhanced neurite outgrowth and viability of primary cultured neocortical neurons, which was suppressed by adenosine A1 and A2A receptor agonists. Oral administration of inosine to mice transiently increased its concentration in the brain and enhanced neuronal prol… Show more

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Cited by 66 publications
(45 citation statements)
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“…Moreover, adenosine A 1 receptor agonist CHA induces antidepressant-like profile in rats [59]. In line with these results, studies from our group also reported that DPCPX prevented the antidepressant-like effect of adenosine, inosine, and zinc chloride [32,37,38,60].…”
Section: Discussionsupporting
confidence: 81%
“…Moreover, adenosine A 1 receptor agonist CHA induces antidepressant-like profile in rats [59]. In line with these results, studies from our group also reported that DPCPX prevented the antidepressant-like effect of adenosine, inosine, and zinc chloride [32,37,38,60].…”
Section: Discussionsupporting
confidence: 81%
“…administration of inosine decreases the immobility time in behavioral despair models of depression by a mechanism dependent on the activation of adenosine A 1 and A 2A receptors [36]. This antidepressant potential was further confirmed by Muto et al [20], showing that chronic administration of inosine prevented the depressive-like effect in the forced swimming test (FST) and the decreased cellular proliferation in the dentate gyrus in mice subjected to chronic unpredictable stress. A single administration of inosine was also able to significantly increase extracellular-regulated protein kinase (ERK) phosphorylation and the expression of brain-derived neurotrophic factor (BDNF) in mouse hippocampus.…”
Section: Introductionsupporting
confidence: 56%
“…Even though few studies have focused on the physiological roles of inosine, there is a growing body of evidence suggesting that this nucleoside has significant biological effects. It has been suggested that inosine elicits neuroprotective effects in neurons and astrocytes subjected to hypoxia, glucose-oxygen deprivation, and oxidative damage [18,19]; stimulates neurite outgrowth in vitro [20]; and induces axonal outgrowth in vivo and in vitro studies [21][22][23][24][25]. Moreover, systemic administration of inosine causes antinociceptive, antiallodynic, and antihyperalgesic effects in mice [26,27].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Adenosine has been reported to have an antidepressant-like effect in the forced swim paradigm, and this effect has been attributed to the activation of both A 1 and A 2A receptors (Kaster et al, 2004) and the subsequent involvement of K ĂŸ conductances (Kaster et al, 2007a) and the endogenous opioidergic system (Kaster et al, 2007b). Orally administered inosine also reproduces this effect (Muto et al, 2014). Interestingly A 2A receptor gene deficiency and A 2A receptor antagonists, including caffeine, also have antidepressant-like effect in the FST and TST (El Yacoubi et al, 2003;Hodgson et al, 2009) as well as in the chronic unpredictable stress paradigm of depression (Pechlivanova et al, 2012).…”
Section: Purinergic Regulation Of Neuroinflammation In Cns Disordersmentioning
confidence: 90%