Effects of inoculating a levan-forming cariogenic streptococcus on experimental caries in hamsters

Gaffar, Abdul; Coleman, Edward J.; Marcussen, H.W.; Kestenbaum, R.C.

doi:10.1016/0003-9969(70)90030-0

Archives of Oral Biology

1970

DOI: 10.1016/0003-9969(70)90030-0

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Effects of inoculating a levan-forming cariogenic streptococcus on experimental caries in hamsters

Abdul Gaffar

Edward J. Coleman

H.W. Marcussen

et al.

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1974

1989

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Cited by 4 publications

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“…Certain strains of S. salivarius have proven to be cariogenic in hamster (15,29,32) and gnotobiotic rat (17,23,24,31,45) model systems. In fact, S. salivarius may have been the first organism shown to be cariogenic in animals (1).…”

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confidence: 99%

Adherence of Veillonella Species Mediated by Extracellular Glucosyltransferase from Streptococcus salivarius

McCabe

Donkersloot

1977

Infect Immun

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The effect of extracellular products from Streptococcus salivarius on sucrosedependent adherence to smooth surfaces by other oral bacteria was studied in vitro. Strains of Streptococcus mitis, Streptococcus pyogenes, and Veillonella parvula without innate ability to adhere to a steel wire were able to do so when incubated with sucrose and cell-free culture fluid from S. salivarius strains 9759, 25975, CNII, and MEPI. These culture fluids synthesized more adherent material and water-insoluble glucan than those from Streptococcus mutans C67-1 and seven other S. salivarius strains. Among the S. salivarius strains, glucosyltransferase (GT; dextransucrase, EC 2.4.1.5) activity varied more than 100-fold. Cells of Veillonella and S. mitis S3 that had been incubated in culture fluids from S. salivarius 25975 and 9759, respectively, and then washed adhered upon subsequent incubation with sucrose. This was due to adsorbed GT because (i) the adherence was sensitive to dextranase; (ii) it was observed only with the high-GT culture fluids; (iii) it was dependent on sucrose; and (iv) the washed Veillonella cells synthesized glucan, but not fructan, from sucrose. These results suggest that sucrose-dependent adherence of bacteria without such innate ability can be mediated by (i) entrapment in insoluble glucan synthesized by S. salivarius culture fluids, and (ii) prior adsorption of GT from S. salivarius culture fluids. The possibility that GT formed by high-yield strains of S. salivarius is distributed through the mouth by the action of salivary flow and contributes to sucrosedependent adherence and plaque formation is considered.

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confidence: 99%

Adherence of Veillonella Species Mediated by Extracellular Glucosyltransferase from Streptococcus salivarius

McCabe

Donkersloot

1977

Infect Immun

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Production and partial characterization of the extracellular polysaccharides from oral Streptococcus salivarius

Eifuku

Yoshimitsu-Narita

Sato

et al. 1989

Carbohydrate Research

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Mast cells and periodontal disease

Coleman

Schlissel

Gaffar

1974

J of Periodontal Research

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Two groups of littermated hamsters with polyglucan‐forming streptococci in their oral flora, were set up in identical but separate quarters and fed a cariogenic diet. The control group was untreated, whereas the test group was inoculated orally with polyfructan‐forming streptococci (Strain SS‐2) by swabbing the teeth for four days. After forty‐four days, the animals were evaluated for dental caries, bone resorption and gingival mast cell population density. The inoculated hamsters showed a 2.24 X increase in dental caries, an 1.82 X increase in bone resorption, and a 1.50 X increase in mast cell numbers. The increases in each of these three parameters was statistically highly significant. The role of polyfructan‐forming streptococci in causing dental caries directly, and increasing numbers of mast cells with accompanying bone resorption along the alveolar crest and other periodontal disease symptoms is discussed.

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Effects of inoculating a levan-forming cariogenic streptococcus on experimental caries in hamsters

Cited by 4 publications

References 9 publications

Adherence of Veillonella Species Mediated by Extracellular Glucosyltransferase from Streptococcus salivarius

Adherence of Veillonella Species Mediated by Extracellular Glucosyltransferase from Streptococcus salivarius

Production and partial characterization of the extracellular polysaccharides from oral Streptococcus salivarius

Mast cells and periodontal disease

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