Effects of inhibition of phosphodiesterase 3B in pancreatic islets on insulin secretion: a potential link with some stimulatory pathways

Kilanowska, Agnieszka; Szkudelski, Tomasz

doi:10.1080/13813455.2019.1628071

Cited by 6 publications

(5 citation statements)

References 37 publications

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“…Diabetes mellitus is a heterogeneous disorder with multiple etiologies [ 1 , 2 ]. The most prevalent in adults is type 2, a chronic metabolic illness with increasing medical and financial costs [ 3 , 4 ]. The incidence of diabetes in 2015 was 8.8%, and in 2040 it will probably increase to 10.4% [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects

Kilanowska

Ziółkowska

2022

IJMS

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Diabetes mellitus is a heterogeneous disease of complex etiology and pathogenesis. Hyperglycemia leads to many serious complications, but also directly initiates the process of β cell apoptosis. A potential strategy for the preservation of pancreatic β cells in diabetes may be to inhibit the implementation of pro-apoptotic pathways or to enhance the action of pancreatic protective factors. The Hippo signaling pathway is proposed and selected as a target to manipulate the activity of its core proteins in therapy-basic research. MST1 and LATS2, as major upstream signaling kinases of the Hippo pathway, are considered as target candidates for pharmacologically induced tissue regeneration and inhibition of apoptosis. Manipulating the activity of components of the Hippo pathway offers a wide range of possibilities, and thus is a potential tool in the treatment of diabetes and the regeneration of β cells. Therefore, it is important to fully understand the processes involved in apoptosis in diabetic states and completely characterize the role of this pathway in diabetes. Therapy consisting of slowing down or stopping the mechanisms of apoptosis may be an important direction of diabetes treatment in the future.

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Section: Introductionmentioning

confidence: 99%

Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects

Kilanowska

Ziółkowska

2022

IJMS

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“…Type 2 diabetes mellitus (T2DM) is a complex endocrine and metabolic disorder that accounts for 90% of the diabetes cases worldwide. Within T2DM, hyperglycaemia takes place due to the impaired insulin secretion through a dysfunction of the pancreatic b-cells and insulin malfunction [1]. The International Diabetes Federation (IDF) has recorded that approximately 425 million adults were affected by diabetes, with 4 million of fatality cases annually [2].…”

Section: Introductionmentioning

confidence: 99%

The role of lycopene for the amelioration of glycaemic status and peripheral antioxidant capacity among the Type II diabetes mellitus patients: a case–control study

et al. 2021

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“…Diabetes mellitus is a heterogeneous disorder with multiple etiologies [1,2]. The most popular, in adults is type 2, a chronic metabolic illness with increasing medical and financial cost [3,4]. The incidence of diabetes in 2015 was 8.8%, and in 2040 it will probably increase to 10.4% [5].…”

Section: Introductionmentioning

confidence: 99%

Apoptosis in Type 2 Diabetes, Can It be Prevented?

Kilanowska¹,

Ziółkowska²

2021

Preprint

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Diabetes mellitus is a heterogeneous disease of complex etiology and pathogenesis. Hyperglycemia leads to many serious complications, but also directly initiates the process of β cell apoptosis. A potential strategy for the preservation of pancreatic β cells in diabetes may be to inhibit the implementation of pro-apoptotic pathways or to enhance the action of pancreatic protective factors. The HIPPO signaling pathway is proposed and selected as a target to manipulate the activity of its core proteins in therapy - basic research. MST1 and LATS2 as major upstream signaling kinases of the Hippo pathway are considered as target candidates for pharmacologically induced tissue regeneration and inhibition of apoptosis. Manipulating the activity of components of the HiPPO pathway offers a wide range of possibilities, and thus is a potential tool in the treatment of diabetes and the regeneration of β cells. Therefore, it is important to fully understand the processes involved in apoptosis in diabetic states and to fully characterize the role of this pathway in diabetes. Therapy consisting in slowing down or stopping the mechanisms of apoptosis may be an important direction of diabetes treatment shortly.

show abstract

Effects of inhibition of phosphodiesterase 3B in pancreatic islets on insulin secretion: a potential link with some stimulatory pathways

Cited by 6 publications

References 37 publications

Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects

Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects

The role of lycopene for the amelioration of glycaemic status and peripheral antioxidant capacity among the Type II diabetes mellitus patients: a case–control study

Apoptosis in Type 2 Diabetes, Can It be Prevented?

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