Effects of industrially produced 2-dimensional molybdenum disulfide materials in primary human basophils

Lin, Hazel; Castillo, Antonio Esaú Del Río; González, Viviana Jehová; Jacquemin, Lucas; Panda, Jaya Kumar; Bonaccorso, Francesco; Vázquez, Éster; Bianco, Alberto

doi:10.1016/j.impact.2023.100451

Cited by 7 publications

(18 citation statements)

References 56 publications

(60 reference statements)

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“…These ball milled MoS 2 nanosheets were tested on primary human basophils showing low inflammatory responses. 52 The results were analogous for MoS 2 nanosheets produced by the wet-jet milling technique. 53 The latter work exploits the shear forces produced when a material dispersion passes through a nozzle of adjustable size.…”

Section: Toward "Green" 2d Materialsmentioning

confidence: 70%

“…Basophils are also involved in inflammatory and allergic responses. 52 MoS 2 nanosheets manufactured according to two different methods were thus studied using primary human basophils. Overall, the analyzed materials were found to be cytocompatible.…”

Section: D Materials and Innate Immunitymentioning

confidence: 99%

“…However, a very recent study explored the interactions between basophils and MoS 2 . Basophils are also involved in inflammatory and allergic responses . MoS 2 nanosheets manufactured according to two different methods were thus studied using primary human basophils.…”

Section: D Materials and Innate Immunitymentioning

confidence: 99%

“…The authors noted a marginal albeit nonsignificant release of histamine (an important mediator of allergic reactions), with no impact on surface markers of cell activation or viability. The study also highlighted how components such as surfactants or exfoliating agents used in the production of 2D materials can skew the outcome . Further studies are needed to address the interactions with other granulocytes as well as mast cells, key players in allergic responses.…”

Section: D Materials and Innate Immunitymentioning

confidence: 99%

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Environmental and Health Impacts of Graphene and Other Two-Dimensional Materials: A Graphene Flagship Perspective

Lin,

Buerki-Thurnherr,

Kaur

et al. 2024

ACS Nano

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Two-dimensional (2D) materials have attracted tremendous interest ever since the isolation of atomically thin sheets of graphene in 2004 due to the specific and versatile properties of these materials. However, the increasing production and use of 2D materials necessitate a thorough evaluation of the potential impact on human health and the environment. Furthermore, harmonized test protocols are needed with which to assess the safety of 2D materials. The Graphene Flagship project (2013−2023), funded by the European Commission, addressed the identification of the possible hazard of graphene-based materials as well as emerging 2D materials including transition metal dichalcogenides, hexagonal boron nitride, and others. Additionally, socalled green chemistry approaches were explored to achieve the goal of a safe and sustainable production and use of this fascinating family of nanomaterials. The present review provides a compact survey of the findings and the lessons learned in the Graphene Flagship.

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Section: Toward "Green" 2d Materialsmentioning

confidence: 70%

Section: D Materials and Innate Immunitymentioning

confidence: 99%

Section: D Materials and Innate Immunitymentioning

confidence: 99%

Section: D Materials and Innate Immunitymentioning

confidence: 99%

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Environmental and Health Impacts of Graphene and Other Two-Dimensional Materials: A Graphene Flagship Perspective

Lin,

Buerki-Thurnherr,

Kaur

et al. 2024

ACS Nano

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“…Biomedical implants are great creations in human medical history, which are widely used to save countless people from the pain of tissue loss and necrosis, especially in the restoration of hard tissues. − The application of suitable materials with good biocompatibility, matching mechanical properties, and stability is the key to developing implants. − To data, there are three typical implants in clinical applications, including stainless steel, cobalt–chromium alloy, and Ti based alloy. − As shown in Figure , the mechanical properties of medical stainless steel are quite different from those of hard tissue, making it is easy to cause implant failure. − Cobalt-based medical metal materials have excellent mechanical properties, wear resistance, and corrosion resistance, but the release of cobalt, nickel, and other metal ions in the constituent elements easily causes cell and tissue necrosis . Due to the best biocompatibility, matching mechanical properties, and good corrosion resistance, Ti alloys are recognized as the most suitable implant material. , …”

Section: Introductionmentioning

confidence: 99%

Surface Modification and Functionalities for Titanium Dental Implants

Sun,

Liu,

Wang

et al. 2023

ACS Biomater. Sci. Eng.

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Dental implants have become the mainstream strategy for oral restoration, and implant materials are the most important research hot spot in this field. So far, Ti implants dominate all kinds of implants. The surface properties of the Ti implant play decisive roles in osseointegration and antibacterial performance. Surface modifications can significantly change the surface micro/nanotopography and composition of Ti implants, which will effectively improve their hydrophilicity, mechanical properties, osseointegration performance, antibacterial performance, etc. These optimizations will thus improve implant success and service life. In this paper, the latest surface modification techniques of Ti dental implants are systematically and comprehensively reviewed. The various biomedical functionalities of surface modifications are discussed in-depth. Finally, a profound comment on the challenges and opportunities of this frontier is proposed, and the most promising directions for the future were explored.

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Biological effects of molybdenum(IV) sulfide nanoparticles and microparticles in the rat after repeated intratracheal administration

Sobańska,

Sitarek,

Gromadzińska

et al. 2023

J of Applied Toxicology

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In this study, molybdenum(IV) sulfide (MoS2) nanoparticles (97 ± 32 nm) and microparticles (1.92 ± 0.64 μm) stabilized with poly (vinylpolypyrrolidone) (PVP) were administered intratracheally to male and female rats (dose of 1.5 or 5 mg/kg bw), every 14 days for 90 days (seven administrations in total). Blood parameters were assessed during and at the end of the study (hematology, biochemistry including glucose, albumins, uric acid, urea, high density lipoprotein HDL, total cholesterol, triglycerides, aspartate transaminase, and alanine transaminase ALT). Bronchoalveolar lavage fluid (BALF) analyses included cell viability, biochemistry (total protein concentration, lactate dehydrogenase, and glutathione peroxidase activity), and cytokine levels (tumor necrosis factor α, TNF‐α, macrophage inflammatory protein 2‐alpha, MIP‐2, and cytokine‐induced neutrophil chemoattractant‐2, CINC‐2). Tissues were subjected to routine histopathological and electron microscopy (STEM) examinations. No overt signs of chronic toxicity were observed. Differential cell counts in BALF revealed no significant differences between the animal groups. An increase in MIP‐2 and a decrease in TNF‐α were observed in BALF in the exposed males. The histopathological changes in the lung evaluated according to a developed classification system (based on severity of inflammation, range 0–4, with 4 indicating the most severe changes) showed average histopathological score of 1.33 for animals exposed to nanoparticles and microparticles at the lower dose, 1.72 after exposure to nanoparticles at the higher dose, and 2.83 for animals exposed to microparticles at the higher dose. In summary, it was shown that nanosized and microsized MoS2 can trigger dose‐dependent inflammatory reactions in the lungs of rats after multiple intratracheal instillation irrespective of the animal sex. Some evidence indicates a higher lung pro‐inflammatory potential of the microform.

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Effects of industrially produced 2-dimensional molybdenum disulfide materials in primary human basophils

Cited by 7 publications

References 56 publications

Environmental and Health Impacts of Graphene and Other Two-Dimensional Materials: A Graphene Flagship Perspective

Environmental and Health Impacts of Graphene and Other Two-Dimensional Materials: A Graphene Flagship Perspective

Surface Modification and Functionalities for Titanium Dental Implants

Biological effects of molybdenum(IV) sulfide nanoparticles and microparticles in the rat after repeated intratracheal administration

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