Effects of indomethacin and diclofenac on some functions of polymorphonuclear neutrophils

Berradia, N; Marchand-Arvier, M.; Humbert, Jana; Vigneron, C.

doi:10.1111/j.2042-7158.1988.tb05178.x

Cited by 7 publications

(4 citation statements)

References 9 publications

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“…Otherwise, it is well known that some NSAIDs inhibit PMN activity by reduction of the oxidative metabolism and therefore a rate of free radicals generated at the inflammatory site (Berradia et al, 1988;Yuda et al, 1991). It is well known that the inhibitory effect of some NSAIDs on PMN O 2…”

Section: But Enhances Omentioning

confidence: 99%

In vitro effects of aqueous seeds extract of Acacia cyanophylla on the opsonized zymosan-induced superoxide anions production by rat polymorphonuclear leukocytes

Abbouyi¹,

Toumi²,

Hachimi³

et al. 2004

Journal of Ethnopharmacology

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Section: But Enhances Omentioning

confidence: 99%

In vitro effects of aqueous seeds extract of Acacia cyanophylla on the opsonized zymosan-induced superoxide anions production by rat polymorphonuclear leukocytes

Abbouyi¹,

Toumi²,

Hachimi³

et al. 2004

Journal of Ethnopharmacology

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“…We demonstrated in vivo that indomethacin inhibited the IL-8-induced infiltration of leukocytes. Indomethacin was also reported to inhibit adhesivity and chemotaxis of neutrophils in response to zymosan-activated serum or N-formyl-methionyl-leucyl-phenylalanine (FMLP) [26] and the release of lysosomal enzymes and the production of superoxide anions by neutrophils [27].…”

Section: Discussionmentioning

confidence: 99%

Involvement of interleukin-8 in dialysis-related arthritis

Takayama

Miyazaki

Aoyama

et al. 1998

Kidney International

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To elucidate the role of interleukin (IL)-8, a chemotactic factor for neutrophils, in dialysis-related arthritis (DRA) of patients on long-term hemodialysis, the concentration of IL-8 was measured in the synovial fluids of DRA patients with acute arthralgia and joint swelling, and was compared with those in patients with rheumatoid arthritis (RA) and patients with osteoarthritis (OA). We noted a marked elevation of IL-8 in the joint fluids of patients with DRA and RA as compared with OA. Furthermore, to determine the role of IL-8 in synovitis, we examined the in vivo effect of intra-articular injection of human recombinant IL-8 on leukocyte infiltration into the joint space of rabbits. A single injection of IL-8 to the joints of rabbits induced rapid infiltration of neutrophils into the joint space and synovial tissues, which reached a maximum in four hours. The oral administration of indometacin farnesil (a prodrug that is converted to indomethacin after intestinal absorption) before the injection of IL-8 alleviated the infiltration of neutrophils. When human synovial cells were incubated with tumor necrosis factor (TNF)-alpha, the expression of IL-8 mRNA and IL-8 production in the cultured synovial cells were increased. The TNF-alpha-stimulated expression of IL-8 mRNA and IL-8 production in the cultured synovial cells were markedly inhibited by dexamethasone. In conclusion, IL-8 levels were markedly elevated in the joint fluids of patients with DRA. Interleukin-8 released from synovial cells may be an important factor to induce acute inflammation in DRA. Dexamethasone and indomethacin may be effective for DRA by inhibiting the production and chemotactic actions of IL-8, respectively.

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“…of local oropharyngeal inflammation and pain are mouthwashes, sprays and gargles, whose advantages over other formulations include fewer side effects and drug interactions, and particularly their greater contact and activity at the oropharyngeal site where the main inflammatory mediators are released. The main mechanism of action explaining the activity of NSAIDs is the inhibition of prostaglandin synthesis, however it has been reported that some NSAIDs can also scavenge free radicals [12][13][14][15][16] and inhibit the respiratory bursts of human neutrophils and the related release of ROS/RNS [17][18][19][20], which indicates the presence of an important additional mechanism that needs to be taken into account and investigated when making a pharmacological evaluation. Diclofenac-choline (DC), (obtained by a new salification process of diclofenac) has recently been proposed in the spray formulation for the symptomatic treatment of oropharyngeal inflammatory conditions and pain.…”

Section: Introduction ▼mentioning

confidence: 99%

“…With reference to local oropharyngeal inflammation and pain, topical formulation of NSAIDs such as flurbiprofen gel, ketorolac rinse or diclofenac itself have been found to lead to useful clinical results. Activated PMNs are present during oropharyngeal inflammation and various authors have challenged NSAIDs and diclofenac with neutrophil respiratory bursts releasing ROS/RNS, and gen-erally concluded that NSAIDs and diclofenac have an inhibitory effect [17][18][19][20]. However, these data have been obtained using relatively small concentrations and long incubation times of 30 or 60 min neither of which apply to the frequent short time associated with the practical use of NSAID-containing mouthwashes or sprays.…”

mentioning

confidence: 99%

Diclofenac-Choline Antioxidant Activity Investigated by means of Luminol Amplified Chemiluminescence of Human Neutrophil Bursts and Electron Paramagnetic Resonance Spectroscopy

et al. 2014

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A new diclofenac salt called diclofenac-choline (DC) has recently been proposed for the symptomatic treatment of oropharyngeal inflammatory processes and pain because its greater water solubility allows the use of high concentrations, which are useful when the contact time between the drug and the oropharyngeal mucosa is brief, as in the case of mouthwashes or spray formulations. The antioxidant activity of DC has not yet been investigated, and so the aim was to use luminol-amplified-chemiluminescence (LACL) to verify whether various concentrations of DC (1.48, 0.74 and 0.37?mg/mL for incubation times of 2, 4 and 8?min) interfere with oxygen and nitrogen radicals during the course of human neutrophils respiratory bursts; electron paramagnetic resonance (EPR) spectroscopy was used to investigate its direct antiradical (scavenger) activity. The EPR findings showed that DC has concentration-dependent scavenging activity against the ABTS, the DPPH, and the hydroxyl radicals, but no activity on superoxide anion, as has been previously reported in the case of other NSAIDs. LACL revealed an inhibitory effect that was statistically significant after only 2?min of incubation, and similar after 4 and 8?min. The effects on the peroxynitrite radical paralleled those observed in the previous test. High concentrations and short incubation times showed that there is no interference on PMN viability, and so the inhibitory findings must be attributed to the effect of the drug. The anti-inflammatory effects of DC cannot be attributed solely to the inhibition of prostaglandin synthesis, but its effects on free radicals and neutrophil bursts suggest that they may contribute to its final therapeutic effect.

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Effects of indomethacin and diclofenac on some functions of polymorphonuclear neutrophils

Cited by 7 publications

References 9 publications

In vitro effects of aqueous seeds extract of Acacia cyanophylla on the opsonized zymosan-induced superoxide anions production by rat polymorphonuclear leukocytes

In vitro effects of aqueous seeds extract of Acacia cyanophylla on the opsonized zymosan-induced superoxide anions production by rat polymorphonuclear leukocytes

Involvement of interleukin-8 in dialysis-related arthritis

Diclofenac-Choline Antioxidant Activity Investigated by means of Luminol Amplified Chemiluminescence of Human Neutrophil Bursts and Electron Paramagnetic Resonance Spectroscopy

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