Effects of in vivo Gonadotropin Treatment on Estrogen Levels in the Testis of the Immature Rat1

Pomerantz, David K.

doi:10.1095/biolreprod21.5.1247

Cited by 42 publications

(26 citation statements)

References 22 publications

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“…Oestradiol in testicular extracts was measured by the method of Pomerantz (1979 Injection of 100 i.u. hCG produced a significant increase in serum testosterone at 2 h (24-4 ± 3-2 ng/ml) compared with 6-2 ± 1-2 ng/ml for controls (Text- fig.…”

Section: Introductionmentioning

confidence: 99%

Effect of oestradiol and tamoxifen on the testosterone response in male rats to a single injection of hCG

Hodgson¹,

Urquhart²,

Kretser³

1983

Reproduction

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Section: Introductionmentioning

confidence: 99%

Effect of oestradiol and tamoxifen on the testosterone response in male rats to a single injection of hCG

Hodgson¹,

Urquhart²,

Kretser³

1983

Reproduction

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“…65(12): 1343-1345, 2003 A portion of the testosterone (T) produced by the testis is converted to estradiol-17β (E 2 ) by aromatase enzyme activity [11]. In the testes of many species [2,17], including dogs [3], the E 2 -secreting cells are the Sertoli cells and/or the Leydig cells [13,20]. In men [6,19] abnormally increased testicular E 2 production causes spermatogenic dysfunction, and long-term E 2 administration has been shown to inhibit spermatogenesis in dogs [8,15].…”

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confidence: 99%

“…The Sertoli cells and Leydig cells of the rat testis are able to produce E 2 [7,13]. E 2 secretion by Sertoli cells increases after FSH administration in the rat [13], but there is no change in E 2 production after FSH administration in the rabbit testis [17].…”

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confidence: 99%

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Therapeutic Effect of Aromatase Inhibitor in Two Azoospermic Dogs with High Plasma Estradiol-17β Levels

Kawakami

Taguchi

Hirano

et al. 2003

The Journal of Veterinary Medical Science

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ABSTRACT. Two azoospermic dogs with high plasma estradiol-17β (E 2 ) levels were subcutaneously injected with an aromatase inhibitor (AI), 4-androstene-4-ol-3,17-dione, 2 mg every other day for 4 weeks. Before the AI treatment the plasma E 2 levels of the two dogs (21 and 22 pg/ml, respectively) were higher than those of 2 normal dogs (8.1 and 12.3 pg/ml), and they fell to 11-17 pg/ml between 1 and 4 weeks after the start of AI treatment. The plasma testosterone levels after the start of AI treatment had increased to 2.1-3.1 ng/ ml. A small number of sperm were detected in the semen of the two dogs between 3 and 6 weeks after the start of AI treatment. Th ese results indicate that the testicular function of infertile dogs with high plasma E 2 levels can be temporarily improved by AI therapy. KEY WORDS: aromatase inhibitor, azoospermia, canine.J. Vet. Med. Sci. 65(12): 1343-1345, 2003 A portion of the testosterone (T) produced by the testis is converted to estradiol-17β (E 2 ) by aromatase enzyme activity [11]. In the testes of many species [2,17], including dogs [3], the E 2 -secreting cells are the Sertoli cells and/or the Leydig cells [13,20]. In men [6,19] abnormally increased testicular E 2 production causes spermatogenic dysfunction, and long-term E 2 administration has been shown to inhibit spermatogenesis in dogs [8,15]. Aromatase inhibitor (AI) blocks the aromatization of androgen to E 2 by inhibiting aromatase enzyme activity [1,18], and AI has been reported to be effective in treating spermatogenic dysfunction in men with high plasma E 2 levels [4]. In the present study, two azoospermic dogs with abnormally increased plasma E 2 levels were treated with AI to improve poor semen quality. Plasma E 2 levels after administration of follicle stimulating hormone extracted from porcine pituitary gland (FSH-P) were measured to investigate the main E 2 -secretory cells in canine testes.The two azoospermic dogs used to assess the effects of AI treatment were a Miniature Poodle (Dog 1) and a Beagle (Dog 2), aged 5 and 2 years, respectively. Dog 1 was owned by a breeder, and Dog 2 was cared for in our university. None of a few bitches mated with either of the two male dogs had conceived. Four semen specimens were collected by digital manipulation with a teaser bitch at one-week intervals. Each specimen was examine for total semen volume, total number of sperm, and morphologically abnormal sperm by the methods described previously [9]. As no sperm had been found in the semen of either Dog 1 or Dog 2 (Table 1), both of them were diagnosed as having azoospermia. Although the two azoospermic dogs were treated with 3 intramuscular injections of 1000 IU hCG per head at one-week intervals, their semen quality had failed to improve. Peripheral blood samples were collected from the two azoospermic dogs at the same time as the semen collections. Plasma E 2 and T levels were measured by the radioimmunoassay described previously [8]. The plasma E 2 levels of the two dogs (21 and 22 pg/ml, respectively) were higher than those o...

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“…It has been reported that high E 2 output by the testes causes azoospermia in humans [4,17]. Transferrin (Tf), a glycoprotein secreted by Sertoli cells, transports Fe ions to germ cells [6,16], and testicular Tf concentrations are useful as an index of Sertoli cell function [13]. It has been reported that there is a strong correlation between the content of Tf secreted by Sertoli cells and spermatogenic function in men [1] and bulls [5].…”

mentioning

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Relationship between Testicular Transferrin and Plasma Estradiol-17.BETA. Concentrations of Dogs with Azoospermia and Dogs with Sertoli Cell Tumors.

Kawakami

Hori

Tsutsui

2001

The Journal of Veterinary Medical Science

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ABSTRACT. Testicular Transferrin (Tf) and peripheral plasma estradiol-17β (E 2 ) concentrations were measured in 3 dogs with azoospermia (AZ dogs), 3 dogs with Sertoli cell tumors (SC dogs), and 5 normal male Beagles. The mean Tf concentrations in the testes of the AZ dogs and the affected testes of the SC dogs, and the plasma E 2 concentrations in both these groups of dogs were significantly higher than the values in normal dogs (P<0.05, 0.01 and 0.01, respectively). Therefore, excessive E 2 secretion by hyperfunctioning Sertoli cells is thought to have caused the azoospermia in the 3 dogs.

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Effects of in vivo Gonadotropin Treatment on Estrogen Levels in the Testis of the Immature Rat1

Cited by 42 publications

References 22 publications

Effect of oestradiol and tamoxifen on the testosterone response in male rats to a single injection of hCG

Effect of oestradiol and tamoxifen on the testosterone response in male rats to a single injection of hCG

Therapeutic Effect of Aromatase Inhibitor in Two Azoospermic Dogs with High Plasma Estradiol-17β Levels

Relationship between Testicular Transferrin and Plasma Estradiol-17.BETA. Concentrations of Dogs with Azoospermia and Dogs with Sertoli Cell Tumors.

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Effects of in vivo Gonadotropin Treatment on Estrogen Levels in the Testis of the Immature Rat1

Cited by 42 publications

References 22 publications

Effect of oestradiol and tamoxifen on the testosterone response in male rats to a single injection of hCG

Effect of oestradiol and tamoxifen on the testosterone response in male rats to a single injection of hCG

Therapeutic Effect of Aromatase Inhibitor in Two Azoospermic Dogs with High Plasma Estradiol-17&beta; Levels

Relationship between Testicular Transferrin and Plasma Estradiol-17.BETA. Concentrations of Dogs with Azoospermia and Dogs with Sertoli Cell Tumors.

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Therapeutic Effect of Aromatase Inhibitor in Two Azoospermic Dogs with High Plasma Estradiol-17β Levels