Relationship between Testicular Transferrin and Plasma Estradiol-17.BETA. Concentrations of Dogs with Azoospermia and Dogs with Sertoli Cell Tumors.

Kawakami, Eiichi; Hori, Tatsuya; Tsutsui, Toshihiko

doi:10.1292/jvms.63.579

Cited by 9 publications

(7 citation statements)

References 13 publications

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“…However, direct evidence of this hypothesis has been lacking, due to a lack of quantitative hormonal analyses in many reported cases and due to conflicting results among those studies in which oestrogen levels were measured. Increased blood oestrogen levels were detected in some cases, 48,49,52,57,58 whereas normal oestrogen levels were described in others 48,59,60 . Until recently, these reported hormonal analyses have been based on single case reports or on very small case series, making it impossible to draw statistically based conclusions.…”

Section: Feminization Syndrome Associated With Testicular Neoplasiamentioning

confidence: 99%

Cutaneous paraneoplastic syndromes in dogs and cats: a review of the literature

Turek

2003

Veterinary Dermatology

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Cutaneous paraneoplastic syndromes are a group of noncancerous dermatoses associated with internal malignancy. Their recognition can facilitate detection and timely treatment of underlying cancer. More than 30 such disorders have been identified in the human scientific literature, whereas only a few are described in veterinary medicine. This may reflect a lower incidence in animals than in people or may be the result of failure to recognize an association between certain skin lesions and neoplasia. Establishing a relationship between a cutaneous disorder and neoplasia can be difficult unless the skin lesions are rare and almost always associated with a particular tumour type, as is the case for most recognized veterinary paraneoplastic dermatoses. Among these are feline paraneoplastic alopecia, feline thymoma-associated exfoliative dermatitis, nodular dermatofibrosis, feminization syndrome associated with testicular tumours, superficial necrolytic dermatitis and paraneoplastic pemphigus. The aetiology of most cutaneous paraneoplastic syndromes has remained elusive in both people and animals.

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Section: Feminization Syndrome Associated With Testicular Neoplasiamentioning

confidence: 99%

Cutaneous paraneoplastic syndromes in dogs and cats: a review of the literature

Turek

2003

Veterinary Dermatology

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“…Levels of LH above the 97.5 percentile of the levels in fertile men were found in 15% of infertile men (28). Higher LH content may stimulate Sertoli cell activity and higher transferrin release, as demonstrated in dogs with azoospermia (31). Sertoli cells are further known to control the testosterone secretory function of the Leydig cells (34), probably through transferrin release.…”

Section: Discussionmentioning

confidence: 98%

“…Increased Tf secretion by the adult testis has been shown to be associated with impaired spermatogenic function in men (29) and dogs (30,31). Decreased Tf levels were found in oligozoospermic men with varicocele (32,33).…”

Section: Discussionmentioning

confidence: 99%

The impact of hemochromatosis mutations and transferrin genotype on gonadotropin serum levels in infertile men

Buretić‐Tomljanović

Vlastelić

Badovinac

et al. 2009

Fertility and Sterility

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“…The seminal transferrin concentrations in normal dogs seem to be much lower than those in normal humans [2,6,12] or cattle [9]. Although Kawakami et al [17] reported that the mean concentration of transferrin in normal canine testis was 321 ± 32 ng/g, testicular transferrin in animals other than dogs has not been measured. A positive correlation exists between seminal plasma transferrin concentrations and sperm density and between total seminal transferrin and total numbers of sperm in ejaculate in humans [2,6] and cattle [9].…”

Section: Discussionmentioning

confidence: 99%

Seminal Plasma Lactoferrin but Not Transferrin Reflects Gonadal Function in Dogs

Kikuchi

Mizoroki

Kubo

et al. 2003

The Journal of Veterinary Medical Science

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ABSTRACT. Lactoferrin purified from canine seminal plasma by a three-step chromatography procedure had a molecular mass of 75.2 kDa and cross-reacted with antiserum to equine seminal plasma lactoferrin. Seminal plasma lactoferrin concentrations were determined by a competitive enzyme-linked immunosorbent assay (ELISA) by using rabbit anti-equine lactoferrin antibody and alkaline phosphataselabeled goat anti-rabbit IgG antibody in 14 normal dogs and found to range from 12 to 197 µg/ml, with a mean value of 77 ± 59 µg/ml (the mean ± SD). Seminal plasma transferrin concentrations were determined by a sandwich ELISA with goat antibody to canine serum transferrin and alkaline phosphatase-conjugated goat anti-canine transferrin antibody and found to range from 0.32 to 12.6 µg/ml, with a mean value of 2.44 ± 3.25 µg/ml. The lactoferrin concentration significantly correlated with the sperm concentration (r=0.7025, P<0.01), but there was no significant correlation between the seminal plasma transferrin concentration and sperm density. These results indicate that seminal plasma lactoferrin, but not transferrin, reflects gonadal function. KEY WORDS: canine, lactoferrin, seminal plasma, sperm, transferrin.J. Vet. Med. Sci. 65(6): 679-684, 2003 Lactoferrin is an iron-binding protein (molecular mass of 80 kDa) that is found in various exocrine fluids, blood plasma and specific granules of neutrophils [15]. Lactoferrin has been identified in the seminal plasma of humans [10,19], swine [21] and horses [14]. Lactoferrin seems to be synthesized mainly in the epididymis of mice [27], swine [16] and horses [7], and it is present in the prostate and seminal vesicles, but not in the epididymis, of humans [26]. The physiological role of lactoferrin in the male reproductive tract remains unclear, although lactoferrin has been identified as the sperm-coating antigen in humans [10] and swine [16,21].Transferrin is homologous to lactoferrin and is a major iron transport protein in the circulation [1], and is also found to be present in the seminal plasma of humans [12] and cattle [9]. Transferrin is secreted by the Sertoli cells [13,22] and plays an important role in spermatogenesis by providing iron to developing germ cells, which have specific transferrin receptors [11,24]. Seminal plasma transferrin is known to be a good index of gonadal function in humans [2, 6] and cattle [9], although 20% and 40% of transferrin in semen is contributed by the accessory sex glands of humans [12] and cattle [9], respectively.No information is available about either lactoferrin or transferrin in canine semen. In the present study, an enzyme immunoassay for measuring the concentrations of lactoferrin and transferrin in canine seminal plasma was developed and the relationships between seminal plasma lactoferrin and transferrin concentrations, the number of sperm and sperm motility were examined. MATERIALS AND METHODSSeminal samples: Ejaculate was obtained from 14 normal mature dogs (age unknown). Seminal properties including sperm number and sperm moti...

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Relationship between Testicular Transferrin and Plasma Estradiol-17.BETA. Concentrations of Dogs with Azoospermia and Dogs with Sertoli Cell Tumors.

Cited by 9 publications

References 13 publications

Cutaneous paraneoplastic syndromes in dogs and cats: a review of the literature

Cutaneous paraneoplastic syndromes in dogs and cats: a review of the literature

The impact of hemochromatosis mutations and transferrin genotype on gonadotropin serum levels in infertile men

Seminal Plasma Lactoferrin but Not Transferrin Reflects Gonadal Function in Dogs

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