Effects of imperatorin, the active component from Radix Angelicae (Baizhi), on the blood pressure and oxidative stress in 2K,1C hypertensive rats

Cao, Yanjun; He, Xueling; Wang, Nan; He, Langchong

doi:10.1016/j.phymed.2013.04.021

Cited by 52 publications

(27 citation statements)

References 39 publications

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“…Among them, coumarins were considered as the dominant chemical constituents. It was reported that coumarins possessed various pharmacological effects, such as imperatorin, which had the antihypertensive, antioxidant [5], anti-inflammatory [6], anti-cancer [7], anticonvulsant [8], vasodilatation [9], and anti-HIV-1 [10] activities, and the prevention on lipopolysaccharide (LPS)-induced acute lung injury [11], cerebral ischemia [12], cardiac hypertrophy and heart failure [13]. Isoimperatorin was found to have the anti-Mycobacterium tuberculosis [14] and anti-inflammatory [15] activities, as well as prevention on aflatoxin B 1 -inducible cytotoxicity [16].…”

Section: Var Formosana (Boiss) Shan Et Yuan CV Chuanbaizhi (Radfc)mentioning

confidence: 99%

New coumarins from the roots of Angelica dahurica var. formosana cv. Chuanbaizhi and their inhibition on NO production in LPS-activated RAW264.7 cells

et al. 2015

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Section: Var Formosana (Boiss) Shan Et Yuan CV Chuanbaizhi (Radfc)mentioning

confidence: 99%

New coumarins from the roots of Angelica dahurica var. formosana cv. Chuanbaizhi and their inhibition on NO production in LPS-activated RAW264.7 cells

et al. 2015

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“…Moreover, imperatorin protected cerebral cells against ischemia-induced apoptosis through activating ERK pathways [22]. Other activities of Angelica Dahurica such as antioxidant [23] and anti-inflammatory [24] were also widely reported.…”

Section: Introductionmentioning

confidence: 99%

Angelica Dahurica ethanolic extract improves impaired wound healing by activating angiogenesis in diabetes

Zhang

Wang

et al. 2017

PLoS ONE

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Abnormal angiogenesis plays an important role in impaired wound healing and development of chronic wounds in diabetes mellitus. Angelica dahurica radix is a common traditional Chinese medicine with wide spectrum medicinal effects. In this study, we analyzed the potential roles of Angelica dahurica ethanolic extract (ADEE) in correcting impaired angiogenesis and delayed wound healing in diabetes by using streptozotocin-induced diabetic rats. ADEE treatment accelerated diabetic wound healing through inducing angiogenesis and granulation tissue formation. The angiogenic property of ADEE was subsequently verified ex vivo using aortic ring assays. Furthermore, we investigated the in vitro angiogenic activity of ADEE and its underlying mechanisms using human umbilical vein endothelial cells. ADEE treatment induced HUVECs proliferation, migration, and tube formation, which are typical phenomena of angiogenesis, in dose-dependent manners. These effects were associated with activation of angiogenic signal modulators, including extracellular signal-regulated kinase 1/2 (ERK1/2), Akt, endothelial nitric oxide synthase (eNOS) as well as increased NO production, and independent of affecting VEGF expression. ADEE-induced angiogenic events were inhibited by the MEK inhibitor PD98059, the PI3K inhibitor Wortmannin, and the eNOS inhibitor L-NAME. Our findings highlight an angiogenic role of ADEE and its ability to protect against impaired wound healing, which may be developed as a promising therapy for impaired angiogenesis and delayed wound healing in diabetes.

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“…The protein expression of AKT, eNOS, p47phox, gp91phox, Nox4 and GAPDH was measured by western blot analysis as previously described (13). …”

Section: Methodsmentioning

confidence: 99%

Protective effects of Guanxin Shutong capsule drug-containing serum on tumor necrosis factor-α-induced endothelial dysfunction through nicotinamide adenine dinucleotide phosphate oxidase and the nitric oxide pathway

Cao

Liu

Huang

et al. 2014

Experimental and Therapeutic Medicine

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The Chinese medicinal formula Guanxin Shutong capsule (GXSTC) has been used for almost 10 years as a clinical treatment for chest pain, depression, palpitation and cardiovascular diseases. The aim of this study was to investigate the effects of GXSTC drug-containing serum on tumor necrosis factor-α (TNF-α)-stimulated endothelial cells. Cell viability was measured by MTT assay, and nitric oxide (NO) levels and NO synthase (NOS) activity were measured as standards of endothelial dysfunction. Malondialdehyde (MDA) levels and superoxide dismutase (SOD) activity were evaluated using commercial kits. In addition, the protein expression of endothelial NOS (eNOS), AKT and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits was examined to evaluate the effect of GXSTC drug-containing serum on ECV304 cells. GXSTC significantly reversed the decrease in NO production induced by TNF-α (5 ng/ml) in ECV304 cells. The expression of NADPH oxidase subunits was increased by TNF-α treatment, but markedly inhibited by treatment with GXSTC in TNF-α-stimulated cells. In summary, GXSTC increased the production of NO in ECV304 cells and exerted a protective effect on ECV304 cells stimulated with TNF-α by upregulating the mRNA and protein expression of eNOS. This was accompanied by increased SOD activity and reduced MDA levels. These results suggested that GXSTC protects the endothelium via the NO pathway and exhibits antioxidant effects.

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Effects of imperatorin, the active component from Radix Angelicae (Baizhi), on the blood pressure and oxidative stress in 2K,1C hypertensive rats

Cited by 52 publications

References 39 publications

New coumarins from the roots of Angelica dahurica var. formosana cv. Chuanbaizhi and their inhibition on NO production in LPS-activated RAW264.7 cells

New coumarins from the roots of Angelica dahurica var. formosana cv. Chuanbaizhi and their inhibition on NO production in LPS-activated RAW264.7 cells

Angelica Dahurica ethanolic extract improves impaired wound healing by activating angiogenesis in diabetes

Protective effects of Guanxin Shutong capsule drug-containing serum on tumor necrosis factor-α-induced endothelial dysfunction through nicotinamide adenine dinucleotide phosphate oxidase and the nitric oxide pathway

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