Effects of imperatorin on nicotine-induced anxiety- and memory-related responses and oxidative stress in mice

Budzyńska, Barbara; Boguszewska-Czubara, Anna; Kruk-Słomka, Marta; Skalicka‐Woźniak, Krystyna; Michalak, Agnieszka; Musik, Irena; Biała, Grażyna; Głowniak, Kazimierz

doi:10.1016/j.physbeh.2013.08.019

Cited by 57 publications

(58 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this regard, after 30 s of adaptation period in the illuminated chamber, the door is raised and the time to reenter to the dark compartment is recorded, although in this case no foot-shock is applied. Our mice entered the dark compartment within 10-60 s. The changes in PA performance are expressed as latency index [IL = (TL2-TL1)/TL1], which is calculated for each animal as the difference between retention and training latency times [19].…”

Section: Passive Avoidance Taskmentioning

confidence: 99%

“…The inactive doses of nicotine [19] and DMXBA [12] as well as the active doses of scopolamine [20], DMXBA [12], and MLA [21] were chosen based on previously published results. Each drug is administered separately, 60 min (PAM-2) or 30 min (nicotine) before the memory acquisition/consolidation test or immediately after the memory consolidation test (i.e., nicotine, scopolamine, MLA, DMXBA, and PAM-2 alone).…”

Section: Acute and Chronic Treatmentsmentioning

confidence: 99%

“…24 h later (i.e., Day 2), PA tests were performed and the TL2 value was calculated. The dose and the pretreatment time selection for nicotine were based on our previous results, where it was demonstrated synergistic activity between an inactive dose of nicotine (0.05 mg/kg), after a pretreatment time of 30 min, with an inactive dose of imperatorin [19].…”

Section: Acute and Chronic Treatmentsmentioning

confidence: 99%

See 2 more Smart Citations

The positive allosteric modulator of α7 nicotinic acetylcholine receptors, 3-furan-2-yl-N-p-tolyl-acrylamide, enhances memory processes and stimulates ERK1/2 phosphorylation in mice

Targowska-Duda

Wnorowski

Budzyńska

et al. 2016

Behavioural Brain Research

Self Cite

View full text Add to dashboard Cite

To determine whether 3-furan-2-yl-N-p-tolyl-acrylamide (PAM-2), a positive allosteric modulator of α7 nicotinic acetylcholine receptors (nAChRs), improves memory processes, passive avoidance tests were conducted in male mice after acute and chronic treatments. To determine the neuronal mechanisms underlying the promnesic activity elicited by PAM-2, the effect of this ligand on α7 nAChR up-regulation and ERK1/2 phosphorylation was assessed in the hippocampus and prefrontal cortex. The results indicate that: (1) PAM-2 improves memory acquisition/consolidation after acute treatment (Day 2) and memory consolidation after chronic treatment (Day 22). Although no effect was observed on α7 nAChR up-regulation, the chronic, but not acute, PAM-2 treatment increases ERK1/2 kinase phosphorylation, (2) the promnesic activity of PAM-2 was inhibited by methyllycaconitine, a selective α7-antagonist, confirming the role of α7 nAChRs, (3) a synergistic (acute) effect was observed between inactive doses of PAM-2 (0.1 mg/kg) and DMXBA (0.3 mg/kg), a selective α7-agonist, and (4) PAM-2 reversed the memory impairment elicited by scopolamine, a muscarinic antagonist. The results demonstrate that PAM-2 presents promnesic activity mediated by α7 nAChRs, and is able to trigger ERK1/2 phosphorylation only after chronic treatment.

show abstract

Section: Passive Avoidance Taskmentioning

confidence: 99%

Section: Acute and Chronic Treatmentsmentioning

confidence: 99%

Section: Acute and Chronic Treatmentsmentioning

confidence: 99%

See 1 more Smart Citation

The positive allosteric modulator of α7 nicotinic acetylcholine receptors, 3-furan-2-yl-N-p-tolyl-acrylamide, enhances memory processes and stimulates ERK1/2 phosphorylation in mice

Targowska-Duda

Wnorowski

Budzyńska

et al. 2016

Behavioural Brain Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…For instance, some coumarins are shown to have a strong impact on the central nervous system, acting as anxiolytics or acetylcholinesterase inhibitors (Budzyń ska et al, 2013;Senol et al, 2011). Psoralen, when activated by UVA radiation, interferes with DNA and cellular replication, and thus can be used in disorders associated with increased cell division (psoriasis) or induction of pigmentation (vitiligo) as PUVA therapy (Conforti et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Bioactivity-guided isolation of antimicrobial coumarins from Heracleum mantegazzianum Sommier & Levier (Apiaceae) fruits by high-performance counter-current chromatography

et al. 2015

View full text Add to dashboard Cite

“…Passive avoidance test was performed similarly to that described previously [85]. Mice were placed in the Gemini Avoidance System (San Diego Instruments, Inc.), consisting of 2 darkened chambers with a wire grid floor, separated by a vertical stainless steel wall with an automatic doorway.…”

Section: Methodsmentioning

confidence: 99%

Cyclin A2 promotes DNA repair in the brain during both development and aging

Gygli

Chang

Gokozan

et al. 2016

Aging

View full text Add to dashboard Cite

Various stem cell niches of the brain have differential requirements for Cyclin A2. Cyclin A2 loss results in marked cerebellar dysmorphia, whereas forebrain growth is retarded during early embryonic development yet achieves normal size at birth. To understand the differential requirements of distinct brain regions for Cyclin A2, we utilized neuroanatomical, transgenic mouse, and mathematical modeling techniques to generate testable hypotheses that provide insight into how Cyclin A2 loss results in compensatory forebrain growth during late embryonic development. Using unbiased measurements of the forebrain stem cell niche, we parameterized a mathematical model whereby logistic growth instructs progenitor cells as to the cell-types of their progeny. Our data was consistent with prior findings that progenitors proliferate along an auto-inhibitory growth curve. The growth retardation in CCNA2-null brains corresponded to cell cycle lengthening, imposing a developmental delay. We hypothesized that Cyclin A2 regulates DNA repair and that CCNA2-null progenitors thus experienced lengthened cell cycle. We demonstrate that CCNA2-null progenitors suffer abnormal DNA repair, and implicate Cyclin A2 in double-strand break repair. Cyclin A2's DNA repair functions are conserved among cell lines, neural progenitors, and hippocampal neurons. We further demonstrate that neuronal CCNA2 ablation results in learning and memory deficits in aged mice.

show abstract

Effects of imperatorin on nicotine-induced anxiety- and memory-related responses and oxidative stress in mice

Cited by 57 publications

References 75 publications

The positive allosteric modulator of α7 nicotinic acetylcholine receptors, 3-furan-2-yl-N-p-tolyl-acrylamide, enhances memory processes and stimulates ERK1/2 phosphorylation in mice

The positive allosteric modulator of α7 nicotinic acetylcholine receptors, 3-furan-2-yl-N-p-tolyl-acrylamide, enhances memory processes and stimulates ERK1/2 phosphorylation in mice

Bioactivity-guided isolation of antimicrobial coumarins from Heracleum mantegazzianum Sommier & Levier (Apiaceae) fruits by high-performance counter-current chromatography

Cyclin A2 promotes DNA repair in the brain during both development and aging

Contact Info

Product

Resources

About