2016
DOI: 10.18632/aging.100990
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Abstract: Various stem cell niches of the brain have differential requirements for Cyclin A2. Cyclin A2 loss results in marked cerebellar dysmorphia, whereas forebrain growth is retarded during early embryonic development yet achieves normal size at birth. To understand the differential requirements of distinct brain regions for Cyclin A2, we utilized neuroanatomical, transgenic mouse, and mathematical modeling techniques to generate testable hypotheses that provide insight into how Cyclin A2 loss results in compensator… Show more

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Cited by 9 publications
(12 citation statements)
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References 86 publications
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“…; Gygli et al . ). Arithmetic means for each structure were determined for control and experimental groups, and statistical hypothesis testing was performed by Student's t test.…”
Section: Methodsmentioning
confidence: 97%
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“…; Gygli et al . ). Arithmetic means for each structure were determined for control and experimental groups, and statistical hypothesis testing was performed by Student's t test.…”
Section: Methodsmentioning
confidence: 97%
“…Anxiety testing was performed as described previously by our group (Gygli et al . ). Student's t test was used to compare each outcome between control and experimental groups.…”
Section: Methodsmentioning
confidence: 97%
See 1 more Smart Citation
“…Cyclin A2 (gene name CCNA2), the main mammalian S-phase cyclin, is required for replication fork initiation and S-G 2 progression of dividing cells. However, cyclin A2 has been implicated in other noncanonical cyclin pathways, including cytoskeletal protein regulation via RhoA kinase, 7 detection of DNA double-strand breaks, 8 and regulation of mRNA. 9 Embryonic CCNA2 ablation results in cerebellar cortical dyslamination, dentate gyrus hypoplasia, and developmental delay in forebrain neurons.…”
mentioning
confidence: 99%
“…9 Embryonic CCNA2 ablation results in cerebellar cortical dyslamination, dentate gyrus hypoplasia, and developmental delay in forebrain neurons. 8,10,11 CCNA2 ablation in adult hippocampal neurons, achieved by expressing crerecombinase under the calcium/calmodulin-dependent protein kinase type II alpha chain (CAMKIIa) promoter in a CCNA2 fl/fl background, results in learning and memory deficits. These studies suggested that cyclin A2 may play different roles during development and hippocampal maintenance.…”
mentioning
confidence: 99%