Effects of immune lymphocyte products and serum antibody on the multiplication of Toxoplasma in murine peritoneal macrophages

Production and Properties of Immune Interferon from Spleen Cell Cultures of Toxoplasma‐Infected Mice

“…Based on these findings, a number of attempts have been made to induce anti-Toxoplasma activity within nonimmune macrophages or human monocytes by incubation with supernatants obtained from specifically stimulated immune lymphocytes (2,4,21,22). Independently, we have also demonstrated that in response to antigenic stimulation, spleen cells from Toxoplasma-immune mice elaborate into the medium a soluble factor capable of inducing anti-Toxoplasma T. SHIRAHATA AND K. SHIMIZU activty within nonimmune mouse macrophages (25). W enamed this factor Toxoplasma growth inhibitory factor (Toxo-GIF) (24).…”

Some Physicochemical Characteristics of an Immune Lymphocyte Product Which Inhibits the Multiplication of Toxoplasma within Mouse Macrophages

“…In previous studies, it was shown that antigen-stimulated immune lymphocytes produce a soluble factor which inhibits the multiplication of Toxoplasma within nonimmune mouse macrophages (23)(24)(25). This factor, termed by the authors as Toxoplasma growth inhibitory factor (Toxo-GIF), probably one of the murine lymphokines, was produced in response to specific antigen or nonspecific plant mitogens (25,26).…”

“…This factor, termed by the authors as Toxoplasma growth inhibitory factor (Toxo-GIF), probably one of the murine lymphokines, was produced in response to specific antigen or nonspecific plant mitogens (25,26). Previously, it was also reported that Toxo-GIF appeared to be a de novo synthesized protein produced by immune T lymphocytes (26).…”

“…The assay of Toxo-GIF activity was performed as described previously (25). Briefly, macrophage monolayers were incubated for 0 to 2 hr with the supernatants containing Toxo-GIF and were infected with 105 trophozoites of the virulent RH strain of T. gondii.…”

Fundamental studies on the leukocyte chemotactic factor in lymphokines of dogs infected with Babesia gibsoni.

“…(Ishimine et al, 1978(Ishimine et al, , 1979Makimura & Suzuki, 1977;Noda & Suzuki, 1977;Sethi et al, 1975;Shirahata et et., 1975Shirahata et et., , 1976Shirahata et et., , 1977Nakabayashi et al, 1978 (Ishimine et al, 1978(Ishimine et al, , 1979Suzuki, 1976 (Boyden, 1962;Fudenberg at al., 1976;Weissmann, 1978 (Ishimine et al, 1978(Ishimine et al, , 1979 …”