Effects of IL-10 on OX62, MHC-II and CD86 in bone marrow DCs in rats with organophosphate poisoning

Wang, Ning; Wang, Jinfeng; Jiang, Ronggang

doi:10.3892/etm.2017.5629

Cited by 3 publications

(2 citation statements)

References 24 publications

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“… 11 It can inhibit the differentiation of monocytes into the antigen-presenting cells and the dendritic cells (DCs) and can broadly inhibit the synthesis and expression of inflammatory mediators secreted by monocytes and macrophages. 12 During the process of regulating the inflammatory response and limiting liver injury, IL-10 is mainly involved in reducing inflammatory liver injury, delaying liver regeneration, directly reducing collagen formation, increasing collagenase, and reducing the levels of TNFα to prevent hepatic fibrosis. As the degree of hepatic fibrosis changes in chronic hepatitis, the level of IL-10 decreases, and the magnitude of the decrease in IL-10 is consistent with the degree of liver injury.…”

Section: Discussionmentioning

confidence: 99%

Study of the Expression of Inflammatory Factors IL-4, IL-6, IL-10, and IL-17 in Liver Failure Complicated by Coagulation Dysfunction and Sepsis

Li¹,

Chen²,

Lin³

et al. 2021

JIR

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Objective The present study aims to investigate the cytokines interleukin (IL)-4, IL-6, IL-10, and IL-17 in the peripheral blood of patients with acute-on-chronic liver failure combined with sepsis, patients with acute-on-chronic liver failure, and patients with liver cirrhosis; to investigate the changes in the levels of inflammatory factors in cases of coagulation dysfunction in liver failure combined with sepsis; and to discover more typical inflammatory factors for further evaluation by functional experiments. Methods In the present study, 41 patients with acute-on-chronic liver failure and sepsis were enrolled as study subjects. These patients were compared with 20 patients with either acute-on-chronic liver failure and liver cirrhosis during the same period. The changes in IL-4, IL-6, IL-10, and IL-17 were detected in each group by enzyme-linked immunosorbent assay, and SPSS 17.0 software was adopted for data analysis. Results There were no significant changes in the levels of IL-4 in any of the groups. However, the levels of IL-6, IL-10, and IL-17 were significantly higher in the acute-on-chronic liver failure and sepsis group than in the acute-on-chronic liver failure and the liver cirrhosis groups. Conclusion The present study shows that when liver failure is accompanied by sepsis, the serum levels of inflammatory factors IL-6, IL-10, and IL-17 are significantly increased. This could be closely correlated with the occurrence and development of coagulation dysfunction and sepsis. These findings provide new ideas for delaying the deterioration of patients with liver failure in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Study of the Expression of Inflammatory Factors IL-4, IL-6, IL-10, and IL-17 in Liver Failure Complicated by Coagulation Dysfunction and Sepsis

Li¹,

Chen²,

Lin³

et al. 2021

JIR

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“…Cytokine storm is considered to be an important factor in the pathological process of ACLF ( 4 ). IL-10 is an anti-inflammatory cytokine and immunosuppressive factor that inhibits the differentiation of monocytes to antigen-presenting cells and dendritic cells and inhibits the secretion of inflammatory mediators by a variety of immune cells ( 20 , 21 ). In our study, patients with HBV-associated ACLF who had SBP had higher IL-6 and lower IL-10 levels compared to those who did not have SBP.…”

Section: Discussionmentioning

confidence: 99%

IL-10 predicts the prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure combined with spontaneous bacterial peritonitis

Liu,

Xiao,

Chen

et al. 2023

Front. Med.

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BackgroundSpontaneous bacterial peritonitis (SBP) is common in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). The prognostic value of interleukin-related serum markers for patients with ACLF is coming to the fore. However, there is an unmet need to predict the survival of such patients. We aimed to analyze the independent predictors of 28- and 90-day mortality in HBV-ACLF patients with SBP.MethodsThis was a retrospective study that included 368 patients with HBV-ACLF. In the SBP group, logistic regression analysis was used to understand the independent predictors of mortality at 28-day and 90-day. The accuracy of prediction was analyzed using the area under the receiver operating characteristic curve (AUROC). Finally, decision curve analysis (DCA) was used to determine the clinical utility value.ResultsInterleukin 10 (IL-10) levels were statistically significantly different between the HBV-ACLF group with SBP and without. Aspartate aminotransferase (AST), serum sodium, IL-10 and vasoactive drug treatment were independent risk factors for 28-day mortality. International normalized ratio (INR), AST and IL-10 were independent risk factors for 90-day mortality. IL-10 combined with the Chinese Severe Hepatitis B Study Group-ACLF II score (COSH-ACLF IIs) had excellent performance in predicting 28- and 90-day mortality (AUCs: 0.848 and 0.823, respectively). DCA analysis suggests promising clinical utility.ConclusionIL-10 is an independent predictor of mortality at 28- and 90-day in HBV-ACLF patients with SBP and predictive performance is improved when combined with COSH-ACLF IIs.

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The liver in sepsis: molecular mechanism of liver failure and their potential for clinical translation

Beyer

Hoff

Sommerfeld

et al. 2022

Mol Med

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Liver failure is a life-threatening complication of infections restricting the host's response to infection. The pivotal role of the liver in metabolic, synthetic, and immunological pathways enforces limits the host's ability to control the immune response appropriately, making it vulnerable to ineffective pathogen resistance and tissue damage. Deregulated networks of liver diseases are gradually uncovered by high-throughput, single-cell resolved OMICS technologies visualizing an astonishing diversity of cell types and regulatory interaction driving tolerogenic signaling in health and inflammation in disease. Therefore, this review elucidates the effects of the dysregulated host response on the liver, consequences for the immune response, and possible avenues for personalized therapeutics.

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Effects of IL-10 on OX62, MHC-II and CD86 in bone marrow DCs in rats with organophosphate poisoning

Cited by 3 publications

References 24 publications

Study of the Expression of Inflammatory Factors IL-4, IL-6, IL-10, and IL-17 in Liver Failure Complicated by Coagulation Dysfunction and Sepsis

Study of the Expression of Inflammatory Factors IL-4, IL-6, IL-10, and IL-17 in Liver Failure Complicated by Coagulation Dysfunction and Sepsis

IL-10 predicts the prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure combined with spontaneous bacterial peritonitis

The liver in sepsis: molecular mechanism of liver failure and their potential for clinical translation

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