Effects of ibuprofen on neutrophil function and acute lung injury in canine endotoxin shock

Ra, Balk; Rf, Jacobs; Af, Tryka; Jw, Townsend; Rc, Walls; Rc, Bone

doi:10.1097/00003246-198811000-00008

Cited by 33 publications

(5 citation statements)

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“…Balk et al . [14] used ibuprofen in a canine endotoxic shock model and found that it affected the extent of histological and morphometric lung injury.…”

Section: Discussionmentioning

confidence: 99%

Effects of Ibuprofen on the physiology and outcome of rabbit endotoxic shock

et al. 2002

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Background: Despite major developments in the management of septic shock, the mortality rate had progressively increased. Ibuprofen has been shown to have beneficial physiological effects when used as a treatment. However, there are conflicting results with respect to survival. This study aims to investigate the effect of ibuprofen on vital functions, various physiological parameters and survival during endotoxic shock in rabbits.

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“…Balk et al . [14] used ibuprofen in a canine endotoxic shock model and found that it affected the extent of histological and morphometric lung injury.…”

Section: Discussionmentioning

confidence: 99%

Effects of Ibuprofen on the physiology and outcome of rabbit endotoxic shock

et al. 2002

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“…It is well known that neutrophils play an important role in the genesis of endotoxin shock (9) and at least some type of DIC (10). The deleterious effect of neutrophils is ascribed to their oxygen radical formation.…”

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confidence: 99%

Leukotoxin, 9,10-epoxy-12-octadecenoate: A Possible Responsible Factor in Circulatory Shock and Disseminated Intravascular Coagulation.

Hanaki

Kamiya²,

Ohno³

et al. 1991

Jpn J Med

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We previously demonstrated that neutrophils biosynthesize the Iinoleate epoxide, 9,10epoxy-12-octadecenoate, from Iinoleate and hydroxyl radical. This epoxide is highly cytotoxic, and has been termed leukotoxin. Wedetected leukotoxin in plasma from two patients with infectious endocarditis and circulatory shock. Maximal leukotoxin levels were 580 nmol/ml and 880 nmol/ml, respectively. The leukotoxin levels were affected by hemodialysis or hemofiltration. Disseminated intravascular coagulation was confirmed by blood coagulation studies in these two patients. Leukocytosis was also observed in these patients. In contrast, leukotoxin was not detected in plasma of normal volunteers. Accordingly, leukotoxin synthesized by recruited neutrophils might be a contributory factor in circulatory shock.

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“…Acute respiratory distress syndrome and multiple organ failure are associated with hypercoagulable states [18,20,31,39]. Long bone canal instrumentation can induce bone marrow embolism (bone marrow contents activate coagulation and fibrinolysis) [55,63] and can increase pulmonary permeability, inflammatory cell invasion of the lungs [1,36,40,41], and the coagulopathic states in them [64].…”

Section: Discussionmentioning

confidence: 99%

Femoral Nailing-related Coagulopathy Determined by First-hit Magnitude

Giannoudis

Griensven

Hildebrand

et al. 2008

Clinical Orthopaedics &Amp; Related Research

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We asked whether coagulopathy worsened during femoral intramedullary nailing in the presence of lung contusion and hemorrhagic shock and whether reamed or unreamed nailing influenced these results. In 30 Merino sheep, we induced hemorrhagic shock and/or standardized lung contusion followed by femoral nailing. Six groups of five each were assigned as follows: thoracotomy control groups treated with reamed or unreamed nailing, lung contusion groups treated with reamed or unreamed nailing, and shock and lung contusion groups treated with reamed or unreamed nailing. After lung contusion alone (first hit), the serum values of antithrombin III, factor V, and fibrinogen were considerably altered after reamed and unreamed femoral nailing (second hit) 4 hours postoperatively. In the lung contusion and shock groups, we found a substantial reduction for all serum coagulative parameters between baseline and fixation after reamed and unreamed nailing. The magnitude of the first hit is increased if hemorrhagic shock is added to a lung contusion determined by hemostatic reactions. The magnitude of the injury appears equally important as the type of subsequent surgery and should be considered in planning for fracture fixation in patients at high risk for complications.

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Effects of ibuprofen on neutrophil function and acute lung injury in canine endotoxin shock

Cited by 33 publications

References 0 publications

Effects of Ibuprofen on the physiology and outcome of rabbit endotoxic shock

Effects of Ibuprofen on the physiology and outcome of rabbit endotoxic shock

Leukotoxin, 9,10-epoxy-12-octadecenoate: A Possible Responsible Factor in Circulatory Shock and Disseminated Intravascular Coagulation.

Femoral Nailing-related Coagulopathy Determined by First-hit Magnitude

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