Effects ofSpirulina platensison lipid peroxidation, antioxidant defenses, and tissue damage in kidney of alloxan-induced diabetic rats

Abstract

Chronic hyperglycemia in diabetes causes free radicals overproduction, which contributes to the development of diabetic nephropathy. In modern medicine, no satisfactory therapy is available to cure diabetes mellitus. In that context, we investigated the potential therapeutic action of spirulina-enriched diet on renal impairment and oxidative stress in diabetic rats. Diabetes was induced by a single subcutaneous injection of alloxan (120 mg·kg) in rats. Following alloxan treatment, male Wistar rats were fed daily with 5% spirulina-enriched diet or treated with insulin (0.5 IU·rat) for 3 weeks. Diabetes was associated with hyperglycemia, increase in renal oxidative parameters (lipid peroxidation, thiobarbituric-acid reactive substances, protein carbonyl and advanced oxidation protein products levels, changes in antioxidant enzyme activities), and nephropathology markers. The renal injury induced by alloxan was confirmed by histological study of the diabetic rat kidney. Treatment with spirulina or insulin significantly ameliorated renal dysfunction by reducing oxidative stress, while rats recovered normal kidney histology. Overall, this study indicates that spirulina is efficient in inhibiting hyperglycemia and oxidative stress induced by diabetes, and suggests that the administration of this alga may be helpful in the prevention of diabetic complications. This amelioration was even more pronounced than that caused by insulin injection.

Antioxidant and nephro-protective effect of Juglans regia vegetable oil against lead-induced nephrotoxicity in rats and its characterization by GC-MS

“…The decrease in the activities of SOD, CAT and GPx is indicative of enzymes' inhibition due to excessive ROS production induced by lead exposure in the treated rats. These results are in keeping with the previous reports (Gargouri et al (2018[ 22 ]).…”

“…In the present investigation, a significant decrease in body and absolute kidney weights as well as OSI, was observed in the Pb treated rats. Similar results have been found by Gargouri et al (2018[ 22 ]) in lead treated rats at a dose of 6 g/L lead acetate (via drinking water) for 21 days. The decline of body weight could be explained by a metabolic disorder causing energy metabolism pathways which interfere with lead.…”

Evidence of antidiabetic activity of Spirulina fusiformis against streptozotocin-induced diabetic Wistar albino rats

“…This blue-green alga grows in a warm climate and is a rich source of minerals, vitamins and antioxidant pigments (Sabina et al 2009). Spirulina is being investigated through various studies for its antidiabetic, immunomodulatory and antioxidant activities (Finamore et al 2017;Gargouri et al 2017).…”

The (-)-epigallocatechin gallate (EGCG) ameliorates hyperglycemia and hyperlipidemia - mediated oxidative stress in liver and kidney of alloxan induced diabetic mice

“…Assessment of liver and kidney damage was done by measuring marker indices (i.e. ALT, AST, and LDH, Bilirubine, urea and creatinin), which leak into blood stream upon hepatic and kidney injuries [24][25]. In the present study, alloxan treatment caused severe liver and kidney damage, as evidenced by the significant increase in serum ALT, AST and LDH activities as well as elevated total and direct bilirubin levels in the plasma of diabetic mice.…”