Effects of<i>Piper nigrum</i>extracts: Restorative perspectives of high-fat diet-induced changes on lipid profile, body composition, and hormones in Sprague–Dawley rats

Parim, Brahmanaidu; Nemani, Harishankar; Meriga, Balaji; Pothana, Sailaja; Sajjalaguddam, Ramgopal Rao

doi:10.3109/13880209.2014.980585

Cited by 33 publications

(30 citation statements)

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“…28 Obesity and associated metabolic consequences induce changes that promote apoptosis and atrophy of skeletal muscles. These animals showed significantly increased blood glucose, insulin total cholesterol, triglycerides and calculated HOMA-IR as noted by Sishi et al 4 and Parim et al 30 One of the most important organs responsible for glucose uptake, disposal, and storage is skeletal muscles, which account for about 75% of the whole body's glucose uptake under insulin stimulation. 29 The current study showed that rats fed with HFD for 16 weeks gained more body weight and visceral fat when compared with chow fed group.…”

Section: Discussionsupporting

confidence: 69%

“…29 The current study showed that rats fed with HFD for 16 weeks gained more body weight and visceral fat when compared with chow fed group. These animals showed significantly increased blood glucose, insulin total cholesterol, triglycerides and calculated HOMA-IR as noted by Sishi et al 4 and Parim et al 30 One of the most important organs responsible for glucose uptake, disposal, and storage is skeletal muscles, which account for about 75% of the whole body's glucose uptake under insulin stimulation. 31 Different mechanisms are involved in skeletal muscle's insulin resistance encountered in cases of obesity; impaired skeletal muscle microvascular responses to insulin, 32 oxidative stress caused by obesity that impairs glucose uptake low-grade inflammation and decreased IRS-1 activation.…”

Section: Discussionsupporting

confidence: 69%

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Beneficial effects of metformin on muscle atrophy induced by obesity in rats

Hasan

Shalaby

El‐Gendy

et al. 2018

J of Cellular Biochemistry

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Aim A growing interest to understand the signaling pathways mediating obesity‐induced muscle atrophy is given. Metformin (Met) was reported to possess positive effects on preventing muscle damage and promoting muscle mass maintenance. The aim of the present study to investigate pathways involved in Met effect on obesity induced muscle atrophy. Methods Thirty adult male albino rats were assigned into two groups: normal chew diet fed group as control group (C; n = 10) and high‐fat‐diet (HFD) fed group ( n = 20). After 16 weeks, the HFD‐fed animals were subdivided into two groups; HFD group ( n = 10) and HFD fed treated with oral Met (320 mg/day) treatment (Met, n = 10) for 4 weeks. At the end of the experiment; final body weight, visceral fat weight, fasting blood glucose, insulin, lactate, total cholesterol, triglycerides were measured and calculated homeostatic model assessment insulin resistant (HOMA‐IR) for all groups. Soleus muscle weight, histopathlogical examination and expression of peroxisome proliferator‐activated receptor‐γ coactivator‐1α (PGC‐1α), forkhead box O3 (FoxO3), atrogin‐1/MAFbx, and muscle RING finger 1 (MuRF‐1) were performed. Results HFD‐fed animals showed significant increase in final body weight, visceral fat mass, fasting blood glucose, insulin, calculated HOMA‐IR, lactate, total cholesterol and triglycerides with significant decrease in soleus muscle weight, PGC‐1α and significant increase in FoxO3, atrogin‐1/MAFbx, and MuRF‐1 expression. Also, there was significant decrease in fiber diameter, myosin heavy chain (MHC) I content while collagen content and myosin heavy chain IIa were increased compared with control group. Met‐treated group showed a significant decrease in the measured parameters compared with the HFD group. It also restored the gene expression, morphometric measures and MHC composition toward normal. Conclusion The current study is the first to provide evidence that Met could ameliorate muscle atrophy in high‐fat diet induced obesity and this effect may be in part due to regulation of PGC‐1α‐FoxO3 pathway.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionsupporting

confidence: 69%

Beneficial effects of metformin on muscle atrophy induced by obesity in rats

Hasan

Shalaby

El‐Gendy

et al. 2018

J of Cellular Biochemistry

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“…extracts have shown effect in reducing the body weight, fat, ameliorated high fat diet-induced hyperlipidemia and its constituents. 23 Ginger and pepper have shown to modulate oxidative stress caused by hypercholesterolemia. 24 Ginger has demonstrated decrease in all lipid profile parameters.…”

Section: Discussionmentioning

confidence: 99%

Evaluation ofVyoshadi GugguluandHaritaki Churnain the Management of Dyslipidemia: A Multicenter Prospective Clinical Study

Radhakrishanan¹,

Subose²,

Bhuyan³

2018

Journal of Research in Ayurvedic Sciences

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Introduction: Dyslipidemia (DL) is a principal risk factor in the pathophysiology of cardiovascular diseases (CVD) and diabetes mellitus (DM). It may correlate with Medoroga, which is a risk factor for diseases like Prameha, Hridroga Jwara, Bhagandara, Vrana, Vataroga, etc. Aim: To assess the clinical efficacy of Vyoshadi Guggulu (VG) and Haritaki Churna (HC) in the management of DL and changes in the quality of life of the study participants. Materials and methods:It was a prospective, multicenter, single-arm study. The Ayurvedic formulations VG (2 tablets of 500 mg each TDS) after food with lukewarm water and HC (3 gm bd) were administered for 12 weeks with a follow-up of 2 weeks without interventions. Totally, 146 participants belonging to either sex, 18 to 70 years with low-density lipoprotein (LDL) 100 to 160 mg/dL and/or serum cholesterol 200 to 250 mg/dL and/or serum triglycerides (TG) 150 to 250 mg/dL and those willing and able to participate were included in the study. The outcome measures were changes in lipid profile, clinical safety, and changes in the quality of life.Results: There was a significant reduction (p < 0.005) in the mean serum cholesterol level, i.e., 214.8 reduced to 208.3 after 84 days of treatment and (p < 0.001) in the mean high-density lipoprotein (HDL), i.e., 46.3 reduced to 44.04 after 84 days of treatment. There was no significant change in the serum TG, LDL, and very-low density lipoprotein (VLDL) value. There is also improvement in the quality of life (p < 0.001) of the participants. There are no significant changes observed in the laboratory safety parameters. This corroborated that drugs are safe to use. Conclusion:Vyoshadi Guggulu and Haritaki Churna are effective in the management of DL and are safe to use. Clinical significance:The use of these drugs may lower the complications of DL.

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“…Diet induced obesity in animals revealed the relationship between obesity and poor bone quality, as resolute by suppressed micro architectural and biomechanical properties. [ 29 ] Extreme obesity has been shown to have negative impact on bone health, which is associated with profound increase in the levels of obesity-related factors like TNF-α and IL-6. [ 30 31 32 ] In the present study, the elevated level of TNF-α was observed in HFD induced obese rats.…”

Section: Discussionmentioning

confidence: 99%

Ethanolic fraction of Terminalia tomentosa attenuates biochemical and physiological derangements in diet induced obese rat model by regulating key lipid metabolizing enzymes and adipokines

et al. 2017

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The prevalence of overweight-obesity and associated comorbidities have reached alarming levels necessitating the need to explore effective therapeutics. In the present work, we demonstrated the promising antiobesity activity of ethanolic fraction of Terminalia tomentosa bark (EFTT) in diet induced obese rat model. High Fat Diet (HFD)-fed obese rats were orally administered with EFTT (50, 100 and 200 mg/kg body weight). Changes in body weight, body composition, bone mineral concentration, bone mineral density, plasma glucose, insulin, leptin, adiponectin, circulatory and tissue lipid profiles, and the activities of liver antioxidant enzymes, key lipid metabolic enzymes and mRNA expressions of fatty acid synthase (FAS), peroxisome proliferator-activated receptor gamma (PPAR-γ), leptin and tumor necrosis factor alpha (TNF-α) were assessed in experimental rats in the presence and absence of EFTT. At a dose of 200 mg/kg b.wt, EFTT has substantially attenuated body weight and related patho-physiological alterations in HFD-induced obese rats. These findings were correlated with histological observations of adipose tissue. The therapeutic activity of EFTT could be possibly through restoration of antioxidants status, regulation of key lipid metabolizing enzymes, expression of FAS, leptin, PPAR-γ and by synchronized control of energy metabolism in liver and adipose tissue.

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Effects ofPiper nigrumextracts: Restorative perspectives of high-fat diet-induced changes on lipid profile, body composition, and hormones in Sprague–Dawley rats

Abstract: PnL extracts significantly reduced the body weight, fat%, and ameliorated HFD-induced hyperlipidemia and its constituents.

Cited by 33 publications

References 49 publications

Beneficial effects of metformin on muscle atrophy induced by obesity in rats

Beneficial effects of metformin on muscle atrophy induced by obesity in rats

Evaluation ofVyoshadi GugguluandHaritaki Churnain the Management of Dyslipidemia: A Multicenter Prospective Clinical Study

Ethanolic fraction of Terminalia tomentosa attenuates biochemical and physiological derangements in diet induced obese rat model by regulating key lipid metabolizing enzymes and adipokines

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