“…This is probably due to the presence of transplacentally acquired antibody to PT. PT is a strong adjuvant in several immunologic systems in several animals and humans (14,15,190,235,246,452,453,456,553,561,573,575,578,600,610,649,699,745,746,801,804). This adjuvancy in the experimental-animal model is associated with enhancement of serum antibody responses to other antigens, increased cellular immune responses to various protein antigens, contribution to hyperacute experimental autoallergic encephalomyelitis, and increased anaphylactic sensitivity.…”