1985
DOI: 10.1128/iai.49.1.90-97.1985
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Immune suppression and induction of gamma interferon by pertussis toxin

Abstract: It has been suggested that pertussis toxin is a virulence factor of Bordetella pertussis. Although extracts enriched in pertussis toxin activity have been reported to enhance immune responsiveness, other studies have demonstrated a suppressive ability, suggesting that the toxin may contribute to the virulence of B. pertussis through mechanisms involving immune suppression. We report that purified pertussis toxin suppressed the in vitro immunoglobulin M antibody response of mouse splenocytes to sheep erythrocyt… Show more

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Cited by 21 publications
(4 citation statements)
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“…(19), precipitated in ammonium sulfate, and kept at 4°C . Before use, PT was resuspended in PBS and heat inactivated (at 100°C for 45 min) to eliminate its mitogenic effect (20) .…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…(19), precipitated in ammonium sulfate, and kept at 4°C . Before use, PT was resuspended in PBS and heat inactivated (at 100°C for 45 min) to eliminate its mitogenic effect (20) .…”
Section: Methodsmentioning
confidence: 99%
“…(19), precipitated in ammonium sulfate, and kept at 4°C . Before use, PT was resuspended in PBS and heat inactivated (at 100°C for 45 min) to eliminate its mitogenic effect (20) . Subunits Sl, S2, S3, S4, S5 from B. pertussis, BPPSI, BBSI, and nine fragments of BPSI were expressed in Escherichia coli .…”
Section: Methodsmentioning
confidence: 99%
“…The list of organisms includes: Vibrio cholera (Shenker et al 1980. Holmgren et al 1977 (Khansari et al 1981), Bordelella pertussis (Vogel et al 1985), Candida alhicans (Piccolella et al 1981), rubella, influenza, polio, influenza and parvovirus (Hurwitz & Hackett 1985, Engers et al 1981, Kauffmann et al 1974, Kantzler et al 1974, Soontiens & Van Der Veen 1973. Olson et al 1968).…”
Section: Immunosuppressive Properties Of Suspected Oral Pathogensmentioning
confidence: 99%
“…Antibodies are necessary for control of infection in a mouse model [83] through their opsonization of bacteria for neutrophil killing and PT inhibits this process through its actions on neutrophil trafficking and recruitment [84]. PT suppression of antibody responses is supported by examples in the literature of the inhibitory effects of PT on B cell responses to lipopolysaccharide (LPS) [85], lymphocyte chemotaxis [86] and IgM production [87].…”
Section: Pt Effects On Inflammatory and Immune Responses To B Permentioning
confidence: 99%