Effects of<i>astragalus</i>polysaccharide on intestinal inflammatory damage in goslings infected with gosling plague

Luo, Dongliu; Yang, Na; Liu, Z; Li, T; Wang, H; Ge, Ming; Zhang, R

doi:10.1080/00071668.2020.1859094

Cited by 10 publications

(6 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequently, APS with different concentrations was adopted to treat AR guinea pigs, after which the sneezing and rubbing times of AR guinea pigs were reduced, and the levels of OVA-sIgE, OVA-sIgG1, and pro-inflammatory cytokines were declined in a dose-dependent manner. Relevant studies demonstrated that APS could effectively alleviate inflammatory responses induced by lipopolysaccharide in inflammatory osteolysis 35 and intestinal inflammatory damages in goslings, 36 further supporting that APS imparted an ameliorating role to inflammatory responses in AR guinea pigs.…”

Section: Discussionmentioning

confidence: 82%

Astragalus Polysaccharide Relieves Inflammatory Responses in Guinea Pigs with Allergic Rhinitis via Ameliorating NF-kB-Mediated Treg/Th17 Imbalance

Liu

Luo

et al. 2022

Am J Rhinol�Allergy

View full text Add to dashboard Cite

Background Allergic rhinitis (AR) is regarded as a prevalent and non-infectious inflammation in nasal mucosa, and astragalus polysaccharide (APS) could mitigate inflammation. Objectives Herein, this study probed the specific mechanism of APS in inflammatory responses in AR. Methods Firstly, AR guinea pig models were established through the stimulation and sensitization of ovalbumin (OVA) and received APS treatment. Changes in nasal symptoms were assessed through counting the sneezing and rubbing times of guinea pigs. The change patterns of OVA-specific immunoglobulin-E (OVA-sIgE), OVA-specific immunoglobulin-G1 (OVA-sIgG1), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 in guinea pig serum were identified. Meanwhile, the levels of IL-17, transforming growth factor (TGF)-β, IL-10, and forkhead box protein P3 (Foxp3) in the guinea pig tissues or serum were examined, and CD25+Foxp3+Treg or CD4+IL17+Th17 cell proportion was detected. Afterwards, nuclear factor-kappa B (NF-kB) expression in guinea pig nasal mucosa tissues were examined. Rescue experiments were designed to probe the role of NF-kB overexpression in inflammatory responses and Treg/Th17 imbalance in AR guinea pigs. Results APS treatment reduced sneezing and rubbing times of AR guinea pigs and suppressed OVA-sIgE, OVA-sIgG1, TNF-α, and IL-6 levels in guinea pig serum, and meanwhile, increased CD25+Foxp3+Treg cell proportion while reduced CD4+IL17+Th17 cell proportion in AR guinea pig serum or tissues, in a dose-dependent manner. NF-kB was highly-expressed in AR guinea pigs and down-regulated after APS treatment. NF-kB overexpression facilitated inflammatory responses and Treg/Th17 imbalance in AR. Conclusion APS reduced Treg/Th17 imbalance via suppressing NF-kB expression, thereby ameliorating inflammatory responses in AR.

show abstract

Section: Discussionmentioning

confidence: 82%

Astragalus Polysaccharide Relieves Inflammatory Responses in Guinea Pigs with Allergic Rhinitis via Ameliorating NF-kB-Mediated Treg/Th17 Imbalance

Liu

Luo

et al. 2022

Am J Rhinol�Allergy

View full text Add to dashboard Cite

show abstract

“… 2010 ; Luo et al. 2021 ). The HPLC analysis profiles of HRPCM ( Figure 2 ) and ARPCM ( Figure 3 ) were also established based on a previous study to identify the indicative component and calculate their contents (Zhang 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Comparative study on the gastrointestinal- and immune- regulation functions of Hedysari Radix Praeparata Cum Melle and Astragali Radix Praeparata cum Melle in rats with spleen-qi deficiency, based on fuzzy matter-element analysis

Zhang

et al. 2022

Pharmaceutical Biology

View full text Add to dashboard Cite

Context Hedysari Radix Praeparata Cum Melle (HRPCM) and Astragali Radix Praeparata Cum Melle (ARPCM) are used interchangeably in clinics to treat spleen-qi deficiency (SQD) symptom mainly including gastrointestinal dysfunction and decreased immunity, which has unknown differences in efficacy. Objective To investigate the differences between HRPCM and ARPCM on intervening gastrointestinal- and immune-function with SQD syndrome. Materials and methods After the SQD model was established, the Sprague–Dawley (SD) rats were randomly divided into nine groups ( n = 10): normal; model; Bu-Zhong-Yi-Qi Pills; 18.9, 12.6 and 6.3 g/kg dose groups of HRPCM and ARPCM. Gastrointestinal function including d -xylose, gastrin, amylase vasoactive intestinal peptide, motilin, pepsin, H + /K + -ATPase, Na + /K + -ATPase, sodium-glucose cotransporter 1 (SGLT1), glucose transporter 2 (GLUT2) and immune function including spleen and thymus index, blood routine, interleukin (IL)-2, IL-6, interferon-γ (IFN-γ), tumour necrosis factor-α (TNF-α), immunoglobulin (Ig) M, IgA, IgG and delayed-type hypersensitivity (DTH) were detected. Finally, the efficacy differences were analysed comprehensively by the fuzzy matter-element method. Results In regulating immune, the doses differences in efficacy between HRPCM and ARPCM showed in the high-dose (18.9 g/kg), but there were no differences in the middle- and low- dose (12.6 and 6.37 g/kg); the efficacy differences were primarily reflected in levels of IL-6, IFN-γ, TNF-α and IgM in serum, and the mRNA expression of IL-6 and IFN-γ in the spleen. In regulating gastrointestinal, the efficacy differences were primarily reflected in the levels of D -xylose, MTL, and GAS in serum, and the mRNA and protein expression of SGLT1 and GLUT2 in jejunum and ileum. Discussion and conclusions HRPCM is more effective than ARPCM on regulating gastrointestinal function and immune function with SQD syndrome. Therefore, we propose that HRPCM should be mainly used to treat SQD syndrome in the future.

show abstract

“…Regulating the nutritive value of poultry diets in a fitting manner may enhance gut tissue integrity, maintain the balance between microbial populations and low numbers of potentially pathogenic strains, support appropriate immune responses, and control inflammation, all of which are factors that affect disease resistance in young poultry ( Jha and Mishra, 2021 ; Luo et al, 2021 ). In the present study, we used high-throughput sequencing of the V3–V4 region of the 16S rRNA genes to investigate the effects of dietary protein and fiber levels on cecal microbiota composition in goslings.…”

Section: Discussionmentioning

confidence: 99%

The effects of dietary protein and fiber levels on growth performance, gout occurrence, intestinal microbial communities, and immunoregulation in the gut-kidney axis of goslings

Huang

et al. 2022

Poultry Science

View full text Add to dashboard Cite

Effects ofastragaluspolysaccharide on intestinal inflammatory damage in goslings infected with gosling plague

Cited by 10 publications

References 46 publications

Astragalus Polysaccharide Relieves Inflammatory Responses in Guinea Pigs with Allergic Rhinitis via Ameliorating NF-kB-Mediated Treg/Th17 Imbalance

Astragalus Polysaccharide Relieves Inflammatory Responses in Guinea Pigs with Allergic Rhinitis via Ameliorating NF-kB-Mediated Treg/Th17 Imbalance

Comparative study on the gastrointestinal- and immune- regulation functions of Hedysari Radix Praeparata Cum Melle and Astragali Radix Praeparata cum Melle in rats with spleen-qi deficiency, based on fuzzy matter-element analysis

The effects of dietary protein and fiber levels on growth performance, gout occurrence, intestinal microbial communities, and immunoregulation in the gut-kidney axis of goslings

Contact Info

Product

Resources

About