Effects of<i>Aloe vera</i>Supplementation in Subjects with Prediabetes/Metabolic Syndrome

Devaraj, Sridevi; Yimam, Mesfin; Brownell, Lidia; Jialal, Ishwarlal; Singh, Sital; Jia, Qi

doi:10.1089/met.2012.0066

Cited by 75 publications

(85 citation statements)

References 17 publications

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“…64 attributed the hypoglycaemic activity of Aloe to both the gel polysaccharides and the phenol aloesin. On the other hand, standardised aloe preparations offer an attractive alternative for reverting the impaired fasting glucose and impaired glucose tolerance observed under conditions of prediabetes/ metabolic syndrome, 65 and aloe gel may be a safe antihyperglycemic and antihypercholesterolemic agent for hyperlipidaemic DM2 patients. 66 …”

Section: Discussionmentioning

confidence: 99%

Histochemistry and immunolocalisation of glucokinin in antidiabetic plants used in traditional Mexican medicine

et al. 2017

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Mexico is a megadiverse country that has 3600 to 4000 species of medicinal plants, of which approximately 800 are used to treat conditions related to diabetes mellitus (DM). DM is a chronic degenerative disease of energy metabolism that exists as two types: type 1 (DM1) and type 2 (DM2). DM is considered a public health problem that affects 7% of the Mexican population older than 20 years. DM is clinically controlled with hypoglycaemic drugs, alpha-glucosidase inhibitors, insulin secretion stimulants or the direct application of insulin. The hypoglycaemic effectiveness of specific molecules has been determined only for some medicinal plants in Mexico used to treat DM2. The presence of molecules called glucokinins, wich are similar to animal insulin molecules, has been reported in some plant species; glucokinins act as both growth factors and regulators of glucose metabolism in plants. Therefore, we hypothesized that the hypoglycaemic effectiveness of some of the popularly used species for the control of DM could be due to the presence of glucokinin, as reported for Bauhinia variegata.The goal of this work was to use histochemistry to detect, the accumulation of protein that is immunocytochemically compatible with glucokinin in slide sections of hypoglycaemic species used as remedies for DM2. The top fourteen most used medicinal plants in Mexico were selected for study via microscopic sections. Proteins were histochemically detected using naphthol blue black and Johansen’s quadruple stain, and the immunocytochemical correspondence of the proteins with glucokinin was investigated using an insulin antibody. All species studied reacted positively to proteins and glucokinin in the same structures. The presence of glucokinin in these structures and the corresponding hypoglycaemic effects are discussed in the context of the actions of other compounds.

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Section: Discussionmentioning

confidence: 99%

Histochemistry and immunolocalisation of glucokinin in antidiabetic plants used in traditional Mexican medicine

et al. 2017

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“…In humans, hypoglycemic and hypolipidemic in Aloe vera gel preparation combined with psyllium seed husks [26], reduced blood glucose and triglyceride level in women treated with aloe vera gel alone [27] or men in combination with glibenclamide [28], lower fasting blood glucose levels when Aloe vera latex is given to non-insulin dependent diabetic patients [7], decreased levels of total serum cholesterol, triglycerides, and low-density lipoproteins when whole-leaf Aloe vera extract administered patients with hyperlipidemia [29], significant reductions in HbA1c, fructosamine, fasting glucose, and insulin when Aloe vera inner leaf gel powder standardized with 2% aloesin given to patients with prediabetes or metabolic syndrome [30] and anti-hyperglycemic and anti-hypercholesterolemic for hyperlipidemic type 2 diabetic patients in Aloe vera leaf gel [31] were reported.…”

Section: Discussionmentioning

confidence: 99%

Blood glucose lowering activity of aloe based composition, UP780, in alloxan induced insulin dependent mouse diabetes model

Yimam

Zhao

Corneliusen

et al. 2014

Diabetol Metab Syndr

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BackgroundThere are a few nutritional approaches to address the increased needs of managing diabetic conditions. Previously it has been reported that UP780, a standardized composition of aloe chromone formulated with an aloe polysaccharide, has a significant impact in reducing HbA1C, fasting blood glucose, fructosamine and plasma insulin level in humans and improved impaired glucose and insulin resistance in high-fat diet-induced and db/db non-insulin dependent diabetic mouse models. Here we describe activity of UP780 and its constituents to improve insulin sensitivity in alloxan induced insulin dependent diabetic mouse model.Materials and methodInsulin dependent diabetes was induced by administering a single intraperitoneal injection of alloxan monohydrate at a dose of 150 mg/kg to CD-1 mice. Aloesin (UP394) was formulated with an Aloe vera inner leaf gel powder polysaccharide (Qmatrix) to yield a composition designated UP780. Efficacy of oral administration of UP780 at 2000 mg/kg and its constituents (aloesin at 80 mg/kg and Qmatrix at 1920 mg/kg) were evaluated in this model. Glyburide, a sulfonylurea drug used in the treatment of type 2 diabetes, was used at 5 mg/kg as a positive control. Effect of UP780 on non-diabetic normal mice was also addressed.ResultsMice administered intraperitoneal alloxan monohydrate developed progressive type-1 diabetes like symptom. After 4 weeks of daily oral administration, reductions of 35.9%, 17.2% and 11.6% in fasting blood glucose levels were observed for UP780, the UP780 Aloe vera inner leaf gel polysaccharide preparation without chromone (Qmatrix), and Aloesin (UP394), treated animals respectively, compared to vehicle treated animals. UP780 has no impact on blood glucose level of non-diabetic healthy mice. UP780 showed statistically significant improvement for blood glucose clearance in oral glucose tolerance tests. Similarly, enhanced improvement in plasma insulin level and statistically significant reduction in triglyceride level was also observed for animals treated with the composition.ConclusionThese findings suggest that UP780, a chromone standardized Aloe based composition, could possibly be used as a natural supplement alternative to facilitate maintenance of healthy blood glucose levels.

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“…Many alternative therapies — including the anti-inflammatory salsalate [6], rice-containing resistant starch [7], aloe vera [8], and polyphenol-containing compounds such as cinnamon [9] and curcumin [10] — have been suggested to decrease glycemia in individuals with pre-diabetes. Because there have been no long-term trials utilizing these substances, there is no definitive evidence that they are effective; thus, there are no official recommendations for their use.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of Elaeis guineensis and Ficus deltoidea leaf extracts in adults with pre-diabetes

Schwartz¹,

Feldman²,

Krieger³

2013

Nutr J

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BackgroundIndividuals with pre-diabetes (fasting glucose 100–125 mg/dl) are at increased risk of developing diabetes; 50% of U.S. adults aged ≥65 y had pre-diabetes in 2005–08. Extracts of the leaves of E. guineensis (a tropical plant producing edible oil), and F. deltoidea (a traditional tea) contain phenolic compounds that have hypoglycemic effects in vitro and in vivo. Therefore, a study of the efficacy and safety of these leaf extracts was undertaken.MethodsOtherwise healthy adults with pre-diabetes (15m/15f; aged 21 to 65 y; BMI ≥25 and < 40 kg/m2) were assigned to one of 3 groups for 8 weeks: E. guineensis leaf extract 500 mg or 1000 mg or F. deltoidea leaf extract 1000 mg. Assessments at baseline and throughout the study included: fasting plasma glucose, insulin, OGTT, and HOMA-IR; body weight and waist circumference; vital signs, comprehensive metabolic and lipid panels. Statistical analyses included paired Student’s t-test and ANCOVA or non-parametric tests when indicated.ResultsE. guineensis intervention for 8 weeks decreased fasting plasma glucose and insulin levels, glucose and insulin areas under the curve, and insulin resistance, and increased insulin sensitivity. The 500 mg dose of E. guineensis had a more consistent effect on reducing glycemia than the 1000 mg dose and the insulin findings at the two dose levels were somewhat inconsistent. Differences in the distribution of baseline insulin levels in the low and high dose groups may explain some of these observed differences in responses. F. deltoidea leaf extract had no effect on glycemia variables but both total and LDL cholesterol concentrations were significantly decreased in this group. There were no significant differences in change of weight; however waist circumference was significantly lower in the E. guineensis groups after intervention. At baseline and after 8 weeks of intervention, vital signs and safety lab tests were within normal limits and not significantly different between groups or due to intervention.ConclusionsThese results suggest that the leaf extracts of E. guineensis and F. deltoidea may have positive effects on glucose and lipid levels and are safe for use in humans. Further study is required to determine the maximum effective dosages and the mechanisms of action.

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Effects ofAloe veraSupplementation in Subjects with Prediabetes/Metabolic Syndrome

Abstract: Standardized aloe preparations offer an attractive adjunctive strategy to revert the impaired fasting glucose and impaired glucose tolerance observed in conditions of prediabetes/metabolic syndrome.

Cited by 75 publications

References 17 publications

Histochemistry and immunolocalisation of glucokinin in antidiabetic plants used in traditional Mexican medicine

Histochemistry and immunolocalisation of glucokinin in antidiabetic plants used in traditional Mexican medicine

Blood glucose lowering activity of aloe based composition, UP780, in alloxan induced insulin dependent mouse diabetes model

Efficacy and safety of Elaeis guineensis and Ficus deltoidea leaf extracts in adults with pre-diabetes

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