Effects of Hypericum Perforatum, in a rodent model of periodontitis

Paterniti, Irene; Briguglio, Enrico; Mazzon, Emanuela; Galuppo, Maria; Oteri, Giacomo; Cordasco, Gennaro; Cuzzocrea, Salvatore

doi:10.1186/1472-6882-10-73

Cited by 44 publications

(47 citation statements)

References 24 publications

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“…Due to its SSRIs mechanism of action, Hypericum perforatum could be attributed to the significant improvements in serum levels of T4, TSH in irradiated rats. Besides its anti-stressful [47] and anti-inflammatory properties [48], Hypericum perforatum has a powerful antioxidant activity by normalizing serum total antioxidant capacity as well as Malondialdehyde level [49,50]. Also Hypericum perforatum had the ability for protecting neurons from nitric oxide (NO) oxidative stress-induced cell death which occurs in glucose deprivation (GD)-induced neurotoxicity [51].…”

Section: Discussionmentioning

confidence: 99%

Semi-Synthesis of α-Mangostin Derivatives and Evaluation of their Cholinesterase Inhibitory Activity

Khaw¹,

Choon²,

Murugaiyah³

2013

Open Conf. Proceed. J.

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Abstract:The primary goal of the present study aimed to evaluate the prophylactic effect of Hypericum Perforatum L. extract on memory dysfunction induced by scopolamine in adult male albino rats (Rattus norvegicus Berkenout). Rats administered daily P.O Hypericum Perforatum L. extract (350 mg/kg) for two, four, eight weeks and the group of rats at the end of each interval intraperitoneally administered scopolamine (0.4 mg/kg). Scopolamine administration significantly increased the latency time in Morris Water Maze (MWM) task and significantly increased acetylcholinesterase (AChE) activity and significantly decreased noradrenaline, dopamine and serotonin levels in cortex and hippocampus and serum thyroid function (T3, T4 and TSH levels). In groups administered Hypericum Perforatum L. pre-scopolamine injection recorded significant decrease in the latency time in MWM, decrease in ACHE activity and significant increase in the monoamines in cortex and hippocampus and serum T3, T4 and TSH levels. The study highlights the prophylactic efficacy of the neuro-protective effect of Hypericum Perforatum L. extract against scopolamine-induced cognitive impairment.

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Section: Discussionmentioning

confidence: 99%

Semi-Synthesis of α-Mangostin Derivatives and Evaluation of their Cholinesterase Inhibitory Activity

Khaw¹,

Choon²,

Murugaiyah³

2013

Open Conf. Proceed. J.

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“…The mechanism mentioned in previous studies was NF-kB. HP signifi cantly reduces the NF-kB translocation (30,31). Morever, it was demonstrated that HP treatment also inhibits the IkB-α degredation.…”

Section: A C B Dmentioning

confidence: 91%

“…Morever, it was demonstrated that HP treatment also inhibits the IkB-α degredation. NF-kb plays a central role in the regulation of many genes responsible for the cytokines including TNF-α and IL-1β which has role in propagating the extension of a local and systemic infl ammatory process (30,31). However the exact mechanisms by which HP supress NF-kB activation are not known exactly.…”

Section: A C B Dmentioning

confidence: 99%

The effects of Hypericum perforatum on hepatic ischemia- -reperfusion injury in rats

Aydın¹,

Şakrak²,

Tu³

et al. 2014

BLL

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Abstract:Background: Ischemia-reperfusion injury (IR) is associated with a high morbidity and mortality. Several agents have been used to protect the liver after IR. We aimed to investigated the effects of the Hypericum perforatum on IR of the liver. Methods: A total of 62 wistar-albino male rats in 4 groups were used. Sham group (n: 8). Control group (IR, n: 18) was underwent partially liver ischemia and reperfusion (IR). Carboxymethyl cellulose group (CMC n: 18) was given 0.5 % carboxymethyl cellulose before IR for a week. Hypericum perforatum group (HP, n:18) was given 0.5 % carboxymethyl cellulose supplemental the extract of Hypericum perforatum before IR for a week. Blood and liver samples were obtained before ischemia, and 1, 2, 4 hours after the reperfusion. AST, ALT, LDH, TNF-α, IL-6, MDA and advanced oxidation protein products(AOPP) levels were determined in blood samples. Histological evaluation and tissue MDA, AOPP levels were determined. Results: Blood levels of ALT, TNF-α, IL-6 and MDA were signifi cantly low in HP group compared with IR and CMC groups (p < 0.05). There was no difference between the liver injury scrores of IR and CMC groups (p > 0.05). Conslusion: These results indicate that H. perforatum can protect the liver against IR. As antioxidative agent, Hypericum perforatum has both local and systemic protective effects in ischemia reperfusion injury (Tab. 1, Fig. 4, Ref. 31). Text in PDF www.elis.sk.

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“…It is reported in the literature to have antispasmodic, sedative, antiseptic, and antidepressive effects as well as wound-healing effects (10,11). In addition, it is known to be effective against bacteria, viruses, inflammation, and pain (11,12).…”

Section: Introductionmentioning

confidence: 99%

Effects of Nigella sativa and Hypericum perforatum on wound healing

Han¹,

Durmuş²,

Sağliyan³

et al. 2017

Turk J Vet Anim Sci

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IntroductionSkin wounds have long healing processes, and therefore they decrease the life quality of patients. The healing of wounds in a short time without any infections or scars is the desired outcome. In recent years, there have been many studies conducted on alternative treatment methods for wound healing (1-4). The studies related to wound healing aim to achieve wound healing without scar formation as well as accelerating the wound healing (4). However, studies are still ongoing to achieve optimal wound healing.From ancient times, herbal drugs have been used to treat wounds, and in many cultures their uses continue in traditional medicine. Historically, all medicinal preparations were derived from plants. Today, a significant number of drugs are developed from plants that are active against a number of diseases (5).Nigella sativa (NS) extract and its oil have antineoplastic, antibacterial, antifungal, anthelmintic, antidiabetic, and antioxidant effects, and they stimulate the immune system. These effects stem from the active compounds in the contents of NS. There are many active compounds in NS such as thymoquinone, dithymoquinone, thymol, carvacrol (volatile acids), nigellicine, nigellimine-N-oxide, nigellidine (alkaloids), and α-hedrin (triterpene) (6-8). It has been suggested that thymoquinone acts as an antioxidant and prevents membrane lipid peroxidation in tissues (9).Hypericum perforatum (HP) is used in various ways in wound healing. It is reported in the literature to have antispasmodic, sedative, antiseptic, and antidepressive effects as well as wound-healing effects (10,11). In addition, it is known to be effective against bacteria, viruses, inflammation, and pain (11,12).Today, traditional medicine is commonly used in wound healing. The aim of this study was to compare the effects of NS and HP in the form of an oil cream in concentration of 50% on wound healing in terms of clinical, biochemical, and histological aspects. Materials and methods ChemicalsNS, HP oil cream, and placebo cream were used. To prepare NS and HP oil creams, NS oil (Hel-Kim, 50 mL, Mersin, Turkey) and HP oil (Aksu Vital, 20 mL, İstanbul, Turkey) were separately mixed with equal amount of placebo cream.

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Effects of Hypericum Perforatum, in a rodent model of periodontitis

Cited by 44 publications

References 24 publications

Semi-Synthesis of α-Mangostin Derivatives and Evaluation of their Cholinesterase Inhibitory Activity

Semi-Synthesis of α-Mangostin Derivatives and Evaluation of their Cholinesterase Inhibitory Activity

The effects of Hypericum perforatum on hepatic ischemia- -reperfusion injury in rats

Effects of Nigella sativa and Hypericum perforatum on wound healing

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