Effects of hyperbaric oxygen therapy on postoperative recovery after incomplete cervical spinal cord injury

Zhang, Zhiwu; Li, Qian; Yang, Xiao‐Dong; Li, Bin; Zhou, Yijun; Hu, Tianye; Yuan, Jiang; Dong, Ping

doi:10.1038/s41393-021-00674-w

Cited by 4 publications

(4 citation statements)

References 16 publications

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“…373 Another retrospective study of incomplete cervical SCI treated with and without HBO after surgery showed the safety and efficacy of HBO therapy and indicated that the longer the treatment lasts, the better the effects. 374 Asamoto et al also reported that in the HBO group, the improvement rate indicated effectiveness in acute traumatic cervical SCI according to the Neurological Cervical Spine Scale (NCSS). 375 Exercise is a noninvasive treatment that provides stimulation to certain regions of the spinal cord and appears to have multiple applications and benefits for SCI.…”

Section: Clinical Treatment and Researchmentioning

confidence: 95%

Spinal cord injury: molecular mechanisms and therapeutic interventions

Ren

et al. 2023

Sig Transduct Target Ther

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Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate. The challenges of SCI repair include its complex pathological mechanisms and the difficulties of neural regeneration in the central nervous system. In the past few decades, researchers have attempted to completely elucidate the pathological mechanism of SCI and identify effective strategies to promote axon regeneration and neural circuit remodeling, but the results have not been ideal. Recently, new pathological mechanisms of SCI, especially the interactions between immune and neural cell responses, have been revealed by single-cell sequencing and spatial transcriptome analysis. With the development of bioactive materials and stem cells, more attention has been focused on forming intermediate neural networks to promote neural regeneration and neural circuit reconstruction than on promoting axonal regeneration in the corticospinal tract. Furthermore, technologies to control physical parameters such as electricity, magnetism and ultrasound have been constantly innovated and applied in neural cell fate regulation. Among these advanced novel strategies and technologies, stem cell therapy, biomaterial transplantation, and electromagnetic stimulation have entered into the stage of clinical trials, and some of them have already been applied in clinical treatment. In this review, we outline the overall epidemiology and pathophysiology of SCI, expound on the latest research progress related to neural regeneration and circuit reconstruction in detail, and propose future directions for SCI repair and clinical applications.

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Section: Clinical Treatment and Researchmentioning

confidence: 95%

Spinal cord injury: molecular mechanisms and therapeutic interventions

Ren

et al. 2023

Sig Transduct Target Ther

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“…Regarding the anti-apoptotic effects of HBO, Zhang et al. reported that HBO administration inhibits the expression of apoptotic factors and ultimately prevents the death of neurons [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…Hyperbaric oxygen (HBO) is one of the most effective compounds in recent years in the treatment of some diseases such as central nervous system injuries and chronic wounds [ 15 , 16 ]. Studies have shown that HBO increases the survival of neurons and functional recovery in the SCI by inhibiting inflammation and oxidative stress [ 17 , 18 ]. Cheshmi et al.…”

Section: Introductionmentioning

confidence: 99%

Exosomes derived from human placental mesenchymal stem cells in combination with hyperbaric oxygen synergically alleviates spinal cord ischemia-reperfusion injury

Jafari,

Khalatbary,

Taghiloo

et al. 2023

Regenerative Therapy

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“…The latest clinical studies have shown that the neurocervical spine scale (NCSS) has improved significantly in the HBOT group in patients with cervical hyperextension SCI without fractures. HBOT also improved ASIA and Frankel grading, motor function, as well as psychological status among SCI patients [ 69 , 89 , 90 ].…”

Section: Research Progress On the Protective Effects Of Hyperbaric Ox...mentioning

confidence: 99%

Recent advances in the application of gasotransmitters in spinal cord injury

Gao,

Jin,

Zhou

et al. 2024

J Nanobiotechnol

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Spinal Cord Injury (SCI) is a condition characterized by complete or incomplete motor and sensory impairment, as well as dysfunction of the autonomic nervous system, caused by factors such as trauma, tumors, or inflammation. Current treatment methods primarily include traditional approaches like spinal canal decompression and internal fixation surgery, steroid pulse therapy, as well as newer techniques such as stem cell transplantation and brain-spinal cord interfaces. However, the above methods have limited efficacy in promoting axonal and neuronal regeneration. The challenge in medical research today lies in promoting spinal cord neuron regeneration and regulating the disrupted microenvironment of the spinal cord. Studies have shown that gas molecular therapy is increasingly used in medical research, with gasotransmitters such as hydrogen sulfide, nitric oxide, carbon monoxide, oxygen, and hydrogen exhibiting neuroprotective effects in central nervous system diseases. The gas molecular protect against neuronal death and reshape the microenvironment of spinal cord injuries by regulating oxidative, inflammatory and apoptotic processes. At present, gas therapy mainly relies on inhalation for systemic administration, which cannot effectively enrich and release gas in the spinal cord injury area, making it difficult to achieve the expected effects. With the rapid development of nanotechnology, the use of nanocarriers to achieve targeted enrichment and precise control release of gas at Sites of injury has become one of the emerging research directions in SCI. It has shown promising therapeutic effects in preclinical studies and is expected to bring new hope and opportunities for the treatment of SCI. In this review, we will briefly outline the therapeutic effects and research progress of gasotransmitters and nanogas in the treatment of SCI. Graphical Abstract

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Effects of hyperbaric oxygen therapy on postoperative recovery after incomplete cervical spinal cord injury

Cited by 4 publications

References 16 publications

Spinal cord injury: molecular mechanisms and therapeutic interventions

Spinal cord injury: molecular mechanisms and therapeutic interventions

Exosomes derived from human placental mesenchymal stem cells in combination with hyperbaric oxygen synergically alleviates spinal cord ischemia-reperfusion injury

Recent advances in the application of gasotransmitters in spinal cord injury

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