Effects of Hyperbaric Oxygen Therapy on Wound Healing After Tracheal Resection and End-to-End Anastomoses in Rats: Results of Early Observations

Abstract

Our short-term observation results demonstrate that HBO treatment increases tracheal healing and decreases the complication ratios. HBO may be preferred as a supportive treatment modality during the healing period after tracheal surgery.

BTS guideline for oxygen use in adults in healthcare and emergency settings

“…Experimental data have shown hyperbaric oxygen improves anastomotic integrity in animal models 386 387. Recently, 72 patients who underwent elective open infraperitoneal anastomosis for rectal cancer were randomised to 30% or 80% oxygen at induction and for 6 hours postoperatively 388.…”

Safety of hyperbaric oxygen therapy for management of central airway stenosis after lung transplant

“…In large airway ischemia models in mice, HBOT has been shown to promote anastomotic healing, and is known to improve oxygen delivery and wound healing by inducing angiogenesis and neovascularization, recruiting endothelial stem cells, and reducing inflammation . Recent reports have also indicated that HBOT can be safely administered to patients with postoperative airway compromise.…”

“…We also found significant upregulation of hypoxia-inducible genes in donor airways, with expression of VEGFA, KDR, and HMOX1 being associated with prolonged respiratory failure, prolonged hospitalization, extensive airway necrosis, and CAS. 13 In large airway ischemia models in mice, HBOT has been shown to promote anastomotic healing, [30][31][32] and is known to improve oxygen delivery and wound healing by inducing angiogenesis and neovascularization, recruiting endothelial stem cells, and reducing inflammation. [33][34][35][36] Recent reports have also indicated that HBOT can be safely administered to patients with postoperative airway compromise.…”

Effects of hyperbaric oxygen treatment on cartilage regeneration: an experimental study

“…In the third step, the rabbits were decompressed at a rate of 0.15 ATA/min as described elsewhere. [9,10] …”

“…[6][7][8][9][10] In practice, hyperbaric oxygen has also been successfully employed in the treatment of chest wall radionecrosis. [11,12] However, there is insufficient data in the literature regarding cartilage regeneration and growth after the resection of the deformed cartilages on the chest wall.…”