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Cited by 453 publications
(381 citation statements)
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References 447 publications
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“…We found that high concentration oxygen therapy increased Ptco 2 in morbidly obese hospital inpatients to a significantly greater degree than titrating oxygen to achieve a target Spo 2 of 88–92%, regardless of whether hypercapnia was present at baseline or the patient had an acute respiratory disorder. These observations support guidelines that recommend titrated oxygen rather than unrestricted high concentration therapy in patients with conditions associated with chronic respiratory failure, such as morbid obesity 13 and OHS 14 . Further, these results build on earlier observations that oxygen increases Ptco 2 in patients with OHS 8 , 12 by reporting a similar physiological response in patients with simple morbid obesity, without a diagnosis of OHS.…”
Section: Discussionsupporting
confidence: 86%
See 1 more Smart Citation
“…We found that high concentration oxygen therapy increased Ptco 2 in morbidly obese hospital inpatients to a significantly greater degree than titrating oxygen to achieve a target Spo 2 of 88–92%, regardless of whether hypercapnia was present at baseline or the patient had an acute respiratory disorder. These observations support guidelines that recommend titrated oxygen rather than unrestricted high concentration therapy in patients with conditions associated with chronic respiratory failure, such as morbid obesity 13 and OHS 14 . Further, these results build on earlier observations that oxygen increases Ptco 2 in patients with OHS 8 , 12 by reporting a similar physiological response in patients with simple morbid obesity, without a diagnosis of OHS.…”
Section: Discussionsupporting
confidence: 86%
“…[8][9][10][11][12] Guidelines therefore recommend that oxygen therapy be titrated to a target SpO 2 range to avoid the risks of both hypoxaemia and hyperoxaemia. 13,14 In our earlier randomised crossover trial of the effects of 100% oxygen therapy in patients with OHS, three of 24 participants were withdrawn early because PaCO 2 increased by more than 10 mmHg in less than 20 minutes, indicating that high concentration oxygen administration can result in rapid, clinically significant increases in the PaCO 2 . 8 Patients at greatest risk of worsening hypercapnia were those with the most marked hypoxaemia; that is, those most likely to receive oxygen therapy.…”
mentioning
confidence: 99%
“…These target ranges are a step change downwards from the 2008 British Thoracic Society guideline (target range 94-98%) and the 2015 Thoracic Society of Australia and New Zealand guideline (target range 92-96%) 45. Although technically simple to deliver, these recommendations will require a shift in culture—away from oxygen as a friend, to treating oxygen as any other clinical intervention, requiring consideration and careful supervision.…”
mentioning
confidence: 99%
“…The gaps in the plot are due to an absence of data. The blue bar across the chart represents the normal range for Pa CO 2 / Pcbg CO 2 . The peaks in Pa CO 2 are due to the development of type 2 respiratory failure.…”
Section: Electrodiagnostic Studiesmentioning
confidence: 99%