Effects of hydro-alcoholic extract of broccoli (Brassica oleracea) on sensory threshold of pain using the for-malin test in adult male rats

Danesh, Elham; Khatamsaz, Saeed; Shojaeifard, Manzarbano; Khabbaz, Zahra

doi:10.15412/j.jbtw.01030702

Cited by 3 publications

(4 citation statements)

References 29 publications

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“…Increased water and feed intake in all the Br+TZ treatment groups can be due to adaptation of mammalian system against the TZ and broccoli extract supplementation, and broccoli extract has shown the effective preliminary response to counter the toxicity being induced by TZ. Similarly broccoli extract has been found to be antioxidant rich supplement and inducer of physiological pathways against the number of chemical substances, which ultimately tries to restores the normal metabolic activities in the living models [8,9,23,24] and these findings corroborates present investigation.…”

Section: Journal Of Biomedical Sciences Issn 2254-609xsupporting

confidence: 89%

“…Protective antioxidative potential of large number of natural extracts have been reported, which tries to restore stress biomarkers status in vivo [9,24,25]. The amount of proteins in blood hemolysate (Table 3) and plasma (Figure 3) of all group rats was comparable.…”

Section: Journal Of Biomedical Sciences Issn 2254-609xmentioning

confidence: 88%

“…The glucosinolates are found in high concentration in many cruciferous vegetables and it is well established that their breakdown products induce endogenous antioxidant defences in cells in vitro and in vivo. Also Glucosinolates (GSL) have been shown to provide protection from oxidative stress through the elimination of ROS [8,9]. The cultivated Brassicaceae, broccoli (Br) has shown great anticarcinogenic and antioxidative properties and plays an important role in the detoxification when assimilated with diet [10].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Glucosinolates Rich Broccoli extract against Triazophos induced Toxicity in Wistar Rats

Sharma¹,

Sangha²

2016

J Biomedical Sci

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Section: Journal Of Biomedical Sciences Issn 2254-609xsupporting

confidence: 89%

Section: Journal Of Biomedical Sciences Issn 2254-609xmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Glucosinolates Rich Broccoli extract against Triazophos induced Toxicity in Wistar Rats

Sharma¹,

Sangha²

2016

J Biomedical Sci

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“…In preliminary studies, the antinociceptive effects of Brassica oleraceae var. italica inflorescences (Danesh et al 2014 ) and sprouts (Baenas et al 2017 ) were reported in both phases of the formalin test, a first-choice pain model to screen analgesic drugs (Dubuisson and Dennis 1977 ; Dzoyem et al 2017 ). This test refers two phases: an early (neurogenic) and late (inflammatory) (Tjølsen et al 1992 ).…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive and antiedema effects produced in rats by Brassica oleracea var. italica sprouts involving sulforaphane

Guadarrama-Enríquez,

Moreno-Pérez,

González-Trujano

et al. 2023

Inflammopharmacol

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Natural products are recognized as potential analgesics since many of them are part of modern medicine to relieve pain without serious adverse effects. The aim of this study was to investigate the antinociceptive and anti-inflammatory activities of an aqueous extract of Brassica oleracea var. italica sprouts (AEBS) and one of its main reported bioactive metabolites sulforaphane (SFN). Antinociceptive activity of the AEBS (30, 100, and 300 mg/kg, i.p. or 1000 and 2000 mg/kg, p.o.) and SFN (0.1 mg/kg, i.p.) was evaluated in the plantar test in rats to reinforce its analgesic-like activity at central level using the reference drug tramadol (TR, 50 mg/kg, i.p.). The anti-inflammatory-like response was determined in the carrageenan-induced oedema at the same dosages for comparison with ketorolac (KET, 20 mg/kg, i.p.) or indomethacin (INDO, 20 mg/kg, p.o.). A histological analysis of the swollen paw was included to complement the anti-inflammatory response. Additionally, acute toxicity observed in clinical analgesics as the most common adverse effects, such as sedation and/or gastric damage, was also explored. As a result, central and peripheral action of the AEBS was confirmed using enteral and parenteral administration, in which significant reduction of the nociceptive and inflammatory responses resembled the effects of TR, KET, or INDO, respectively, involving the presence of SFN. No adverse or toxic effects were observed in the presence of the AEBS or SFN. In conclusion, this study supports that Brassica oleracea var. italica sprouts are a potential source of antinociceptive natural products such as SFN for therapy of pain alone and associated to an inflammation condition.

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Broccoli sprouts in analgesia – preclinical in vivo studies

et al. 2017

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Effects of hydro-alcoholic extract of broccoli (Brassica oleracea) on sensory threshold of pain using the for-malin test in adult male rats

Cited by 3 publications

References 29 publications

Effects of Glucosinolates Rich Broccoli extract against Triazophos induced Toxicity in Wistar Rats

Effects of Glucosinolates Rich Broccoli extract against Triazophos induced Toxicity in Wistar Rats

Antinociceptive and antiedema effects produced in rats by Brassica oleracea var. italica sprouts involving sulforaphane

Broccoli sprouts in analgesia – preclinical in vivo studies

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