Effects of hydration and dehydration on cyclic adenosine 3?,5?-monophosphate concentration in the rat kidney

Senft, G.; Hoffmann, Markus; Munske, K.; Schultz, Günter

doi:10.1007/bf00363874

Cited by 19 publications

(2 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even if there was a short delay in penetration, there was no suggestion of a stimulated 32P excretion within 30 min. Further, the amount of cyclic AMP presented to the kidney was grossly in excess of the intracellular concentrations in this tissue (Streeto & Reddy, 1967;Senft, Hoffmann, Munske & Schultz, 1968), so that it is reasonable to expect that sufficient cyclic AMP would penetrate to produce a response.…”

Section: Discussionmentioning

confidence: 99%

The Mechanism of Action of Parathyroid Hormone: Lack of Evidence for the Mediation by Cyclic Adenosine 3′, 5′-Monophosphate of Parathyroid Hormone-Stimulated Phosphaturia

Sallis¹

1970

Journal of Endocrinology

View full text Add to dashboard Cite

SUMMARY The excretion of phosphate in the rat after renal infusion of parathyroid hormone or cyclic adenosine 3,′5′-monophosphate (AMP) is described. The hormone stimulated an immediate phosphaturia, but no such response was measurable in the presence of cyclic AMP. Adenyl cyclase activity in kidney cortex was assessed by measuring the conversion of [14C]adenosine 5′-triphosphate to [14C]cyclic AMP. Previous infusion of kidneys with parathyroid hormone did not alter adenyl cyclase activity but the addition of the hormone to kidney tissue in vitro caused a significant increase in the activity of this enzyme. It is suggested that the parathyroid hormone-stimulated phosphaturia is not mediated by cyclic AMP.

show abstract

Section: Discussionmentioning

confidence: 99%

The Mechanism of Action of Parathyroid Hormone: Lack of Evidence for the Mediation by Cyclic Adenosine 3′, 5′-Monophosphate of Parathyroid Hormone-Stimulated Phosphaturia

Sallis¹

1970

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Hypersensitivity due to adrenergic denervation is not associated with altered cyclase levels in the cat heart (37). Renal cortex cyclase activity nearly doubled after water deprivation (38) , and endoge nous cyclic AMP was elevated in the cortex to a greater degree than in the (39). These changes were attributed to the action of endogenous vasopressin released during water deprivation.…”

mentioning

confidence: 98%

Cyclic AMP and Drug Action

Breckenridge¹

1970

Annu. Rev. Pharmacol.

View full text Add to dashboard Cite

The initial concept that cyclic AMP is an intermediate in the actions of glucagon and epinephrine has evolved rapidly to include an array of biologi cal phenomena so extensive that virtually every facet of pharmacology is now involved. Hundreds of relevant publications have been reviewed re cently (1-3), and a monograph on cyclic AMP is forthcoming (4) . Valu able accounts of cyclic AMP effects are available pertaining to polypeptide hormones (5), diazoxide (6), skeletal muscle (7), prostaglandins (8), and insulin secretion (9). It is conceivable that the biological effects of mate rials as diverse as cardiotonic, psychotropic, contraceptive, antibiotic, and diuretic agents will be understood soon in terms of cyclic AMP action. At present our limited insight into the cyclic AMP-related actions of drugs is the result of our imperfect knowledge of cyclic AMP function at the cellu lar level. Understanding of cyclic AMP-linked drug effects probably will be attained in terms of the mechanisms of action of the cyclic nucleotide and the means by which its intracellular concentration is controlled. Therefore, the enzymes of cyclic AMP metabolism and certain basic cell functions have been selected as topics under which to summarize research published, with few exceptions, subsequent to previous reviews. Included are substantial ad ditions to the evidence which supports the concept formulated by Sutherland and his colleagues of cyclic AMP as a second messenger. A few reports sug gest that the momentum for general acceptance of that exceedingly useful thesis is so great that other possible interpretations may be obscured. ADENYL CYCLASERecent studies are in accord with earlier work in showing enzyme activ ity to be associated with particles, to have moderately alkaline pH optima, and to be stimulated by magnesium and fluoride (10-15). A soluble cyclase from E. coli has been purified IOO-fold (16). Fluoride inhibits this enzyme, as well as partially purified cyclase from liver (17) and adipose cells (18). The presence of functional sulfhydryl groups may be inferred from the re quirement for dithioerythrotol in frog erythrocytes (14). The apparent Km for ATP is about 1 X lO-4M in the presence of fluoride in pineal body (11) 1 Abbreviations used in this review are: cyclic AMP (adenosine 3',5' -mono phosphate); db-cyclic AMP (NB,2'-O-dibutyryl adenosine 3',5'-monophosphate); MJ1999 (4-(2cisopropyIamino-l-hydroxyethyl) methanesulfonanilide HeI).

show abstract

Effects of Hormones Other than Parathyroid Hormones on Renal Handling of Phosphate

Ritz¹,

Kreußer²,

Bommer³

1980

Renal Handling of Phosphate

View full text Add to dashboard Cite

Effects of hydration and dehydration on cyclic adenosine 3?,5?-monophosphate concentration in the rat kidney

Cited by 19 publications

References 40 publications

The Mechanism of Action of Parathyroid Hormone: Lack of Evidence for the Mediation by Cyclic Adenosine 3′, 5′-Monophosphate of Parathyroid Hormone-Stimulated Phosphaturia

The Mechanism of Action of Parathyroid Hormone: Lack of Evidence for the Mediation by Cyclic Adenosine 3′, 5′-Monophosphate of Parathyroid Hormone-Stimulated Phosphaturia

Cyclic AMP and Drug Action

Effects of Hormones Other than Parathyroid Hormones on Renal Handling of Phosphate

Contact Info

Product

Resources

About