Effects of Hormones Other than Parathyroid Hormones on Renal Handling of Phosphate

Ritz, Eberhard; Kreußer, W.; Bommer, Jürgen

doi:10.1007/978-1-4615-9152-8_6

Cited by 19 publications

(2 citation statements)

References 241 publications

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“…Other hormones have been implicated in the regulation of Pi metabolism such as growth hormone, thyroid hormone, insulin, glucagon, and cortisol (26). Of these, (GH), acting possibly through its intermediary, somatomedin-C has an established relationship to serum Pi i.e., acromegaly is associated with hyperphosphatemia.…”

Section: Discussionmentioning

confidence: 99%

Circadian Rhythms of Blood Minerals during Adolescence

et al. 1984

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Section: Discussionmentioning

confidence: 99%

Circadian Rhythms of Blood Minerals during Adolescence

et al. 1984

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“…2). As the concentrations of parathyroid hormone and growth hormone are factors known to affect tubular phosphate reabsorption and Tmpo4/GFR [16,17], these hormones were determined. An increased parathyroid hormone level inhibits Tmpo,/GFR.…”

Section: Discussionmentioning

confidence: 99%

Dysfunction of tubular phosphate reabsorption related to glomerular filtration and blood glucose control in diabetic children

1982

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The renal handling of inorganic phosphate was studied by measuring the urinary excretion rate of phosphate (UPO4V), phosphate-(Cr51) EDTA clearance ratio (CPO4/GFR) and maximal tubular reabsorption of phosphate per litre glomerular filtrate (TmPO4/GFR) during fasting in 26 ambulatory Type 1 (insulin-dependent) diabetic children without clinical signs of microangiopathy (age: 7-14 years; duration of disease: 3-14 years). Similar measurements were made in 28 healthy schoolchildren (age: 8-14 years). UPO4 V and CPO4/GFR were significantly enhanced in the diabetic children (p less than 0.001) and correlated with the degree of hyperglycaemia (p less than 0.005). TmPO4/GFR was significantly suppressed in the diabetic children (1.23 versus 1.73 mmol/l, p less than 0.001). This disturbance was neither related to changes in serum parathyroid hormone nor to growth hormone concentrations but was inversely correlated with the degree of hyperglycaemia (r = -0.61, p less than 0.001) and with tubular reabsorption of glucose (r = -0.53, p less than 0.01). In spite of the markedly lowered TmPO4/GFR in the diabetic subjects, the mean maximal (TmPO4) and absolute tubular phosphate reabsorption rates were equal to those of the 28 healthy subjects. Both in the diabetic and healthy subjects, these parameters were positively correlated with glomerular filtration rate which was significantly elevated in the diabetic children (138 versus 109 ml/min per 1.73 m2, p less than 0.01). The study demonstrates a dysfunction in tubular phosphate reabsorption in diabetic children which is related to glycaemic regulation.

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Kidney and Bone: Physiological and Pathophysiological Relationships

Brown

1992

Comprehensive Physiology

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The sections in this article are: Chemical and Cellular Composition of Bone Extracellular Constituents of Bone Bone Cells Development and Structure of Bone Endochondral Ossification Intramembranous Ossification Skeletal Growth and Modeling Principles of Skeletal Growth Skeletal Modeling Epiphyseal Closure Bone Cell Function and Skeletal Growth and Modeling Bone Turnover and the Remodeling Cycle Skeletal Remodeling Cellular Control of Bone Remodeling Fracture Healing Bone Cell Function and Fracture Repair Interrelationships of Kidney and Bone in Normal Physiology General Considerations Overall Calcium Balance Hormonal Control of Mineral Ion Homeostasis Role of the Parathyroid Glands in the Calcium Homeostatic System Bone Cell Function and Ionic Homeostasis Aspects of Renal Function Essential for Normal Skeletal Structure and Function and Ionic Homeostasis Metabolic Bone Disease Osteitis Fibrosa Osteomalacia Osteoporosis Laboratory Evaluation of Metabolic Bone Disease Direct Assays of Calcium‐Regulating Hormones in Blood Clinical Assessment of the Function of Target Organs for Calcium‐Regulating Hormones Abnormalities in Renal Function Leading to Skeletal Disease Abnormalities in Renal Calcium Handling Abnormalities in Renal Phosphate Handling Hypo‐ and Hypermagnesemia Due to Renal Causes Renal Tubular Acidosis Primary Abnormalities in Vitamin D Metabolism Renal Resistance to PTH : Pseudohypoparathyroidism Chronic Renal Insufficiency Pathophysiology of Renal Osteodystrophy Disorders Affecting the Homeostatic Mechanisms Linking Kidney and Bone Primary Hyperparathyroidism Humoral Hypercalcemia of Malignancy Hypoparathyroidism Deficient Quantities and Action of Vitamin D Hypervitaminosis D Sarcoidosis and Other Granulomatous Diseases Other Hormonal Abnormalities and Drugs Affecting Both Bone and Kidney Calcitonin Growth Hormone Estrogen Glucocorticoids Insulin Thyroid Hormones Miscellaneous Associations Between Bone and Kidney Disorders Affecting Both Kidney and Bone Pharmacological Agents Affecting Both Kidney and Bone Effects of Bone Disease on the Kidney

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Effects of Hormones Other than Parathyroid Hormones on Renal Handling of Phosphate

Cited by 19 publications

References 241 publications

Circadian Rhythms of Blood Minerals during Adolescence

Circadian Rhythms of Blood Minerals during Adolescence

Dysfunction of tubular phosphate reabsorption related to glomerular filtration and blood glucose control in diabetic children

Kidney and Bone: Physiological and Pathophysiological Relationships

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