Effects of human amniotic fluid on peritendinous adhesion formation and tendon healing after flexor tendon surgery in rabbits

Özgenel, Güzin Yeşim; Şamli, Billur; Özcan, Mesut

doi:10.1053/jhsu.2001.22524

Cited by 70 publications

(65 citation statements)

References 24 publications

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“…It was shown that the least adhesion and the best healing were observed in tendons treated with human amniotic fluid application. [30] However, no human trial has been reported.…”

Section: Discussionmentioning

confidence: 99%

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Effects of repetitive injections of hyaluronic acid on peritendinous adhesions after flexor tendon repair: a preliminary randomized, placebo-controlled clinical trial

Özgenel¹,

Etöz²

2012

Ulus Travma Acil Cerrahi Derg

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AMAÇBu çalışmada, zon-II fleksör tendon onarımlarından sonra, iki haftalık süre içerisinde enjekte edilen 3 doz hyaluronik asit (HA) enjeksiyonunun plaseboya (salin) karşı etkinliği araştırıldı. GEREÇ VE YÖNTEMÇalışmaya İkinci parmak izole zon-II fleksör tendon hasarlanması olan 22 hasta dahil edildi. Tenorafi öncesi, parmaklar randomize olarak iki gruba ayrıldı; 11 parmakta tenorafi çevresine 3 doz HA enjekte edilirken, aynı şekilde salin enjekte edilen 11 parmak da plasebo grubunu oluşturdu. Birinci doz tenorafi sırasında verildi ve ilave 2 doz 1 hafta ara ile enjekte edildi. Operasyon sonrası Kleinert rehabilitasyon protokolü uygulandı. Eklem hareket açıklığı, 3. hafta, 3. ay ve uzun dönemde total aktif ve pasif eklem açıklığı ölçüle-rek değerlendirildi. Fonksiyonel sonuç, Strickland sınıflan-dırmasına göre belirlendi. BULGULARÜçüncü haftada eklem hareket açıklığı açısından iki grup arasında bir fark tespit edilmedi. Ancak, 3. ay ve uzun dö-nemde, eklem hareket açıklığında, HA enjekte edilen parmaklarda plasebo grubuna göre anlamlı derecede iyileşme olduğu gözlendi. SONUÇBu plasebo kontrollü ön çalışmada, mükerrer HA enjeksiyonlarının, primer tendon onarımında, muhtemelen adezyon azaltıcı etkisine bağlı olarak, klinik sonuçları iyileşti-rebildiği ileri sürülmektedir.Anahtar Sözcükler: Adezyon önleme; hyaluronik asit; tendon adezyonları; tendon onarımı.

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“…It was shown that the least adhesion and the best healing were observed in tendons treated with human amniotic fluid application. [30] However, no human trial has been reported.…”

Section: Discussionmentioning

confidence: 99%

“…A one-week interval was chosen because it was shown that HA was eliminated within 7 days. [15,30,31] This clinical study compared HA to saline. The concentration of electrolytes in normal saline solution (0.9%NaCl) is similar to that of blood and it is metabolically inert (Hoppe et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Effects of repetitive injections of hyaluronic acid on peritendinous adhesions after flexor tendon repair: a preliminary randomized, placebo-controlled clinical trial

Özgenel¹,

Etöz²

2012

Ulus Travma Acil Cerrahi Derg

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“…26 Other studies reported that amniotic membrane may suppress the expression of inflammatory cytokines; IL-1α, IL-1β, thus reducing the inflammatory reaction and reduce the amount of fibrotic tissue in tendon healing process. 27 Rahmadian, et al 28 also reported that lyophilized amniotic membrane has a positive effect on the prevention of adhesion after Achilles tendon repair in rabbits.…”

Section: -25mentioning

confidence: 97%

Effect of lyophilized amniotic membrane, hyaluronic acid, and their combination in preventing adhesion after tendon repair in New Zealand white rabbits

Hadi

Sukmawan

2014

Med J Indones

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Abstrak AbstractBackground: Several promising methods to reduce the peritendinous adhesion after repair include amniotic membrane and hyaluronic acid application on the repaired tendon site. This study aimed to compare the effect of lyophilized amniotic membrane, application of hyaluronic acid, and their combination in preventing peritendinous adhesion after tendon repair in New Zealand white rabbits.Methods: 64 flexor digitorum fibularis tendon from 16 rabbits were cut and then repaired by modified Kessler technique. Samples were allocated into four test groups; group I as control had simple tendon repair, group II had amniotic membrane wrapping at repair site, group III had hyaluronic acid application at repair site, and group IV had combination of amniotic membrane wrapping and hyaluronic acid application. On 6 th week, 8 tendon from each group underwent macroscopic and histologic evaluation of peritendon adhesion by Tang scoring system. The rest of samples were evaluated for tendon gliding at tenth week by measuring active and passive range of motion of metatarsophalangeal joint.

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“…Furthermore, preclinical models in in vivo studies showed that the amniotic fluid facilitates the healing of burns as well as losses of cartilage, bone, tendon and nerve injuries [44,45]. The placenta is also a rich source of collagen, especially collagen type I.…”

Section: New Possibilities Of Application Of Grafts Prepared From Plamentioning

confidence: 99%

Preparation of Amniotic Membrane and It’s Application in the Treatment of Skin Loss and Lyell's Syndrome (Toxic Epidermal Necrolysis): Current State and New Opportunities

Klama-Baryła¹,

Łabuś²,

Kitala³

et al. 2017

J Clin Exp Dermatol Res

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Amniotic membrane is a good protection against bacterial infections, reduces losses of proteins, fluids and electrolytes, decreases pain from burns and accelerates healing. Due to its richness in nutrients and low immunogenicity, it is often used as a skin substitute. Human amnion may be prepared in tissue banks, as biostatic or biovital grafts. There are various methods of amniotic graft preparations developed to make them efficient in surgical treatment and prevent the risk of transmission of infectious diseases. This paper presents the current clinical application of human amnion in the treatment of skin losses, such as burns to the face and Lyell's syndrome (toxic epidermal necrolysis). It also describes new applications of fetal membranes for other diseases. Placental grafts are often an alternative therapy in the situations when standard treatment does not yield desirable effects. Such grafts are especially beneficial in comparison to many other bioactive therapies, including low cost, easy manipulation, capability of promoting cell migration and proliferation and stimulation of stem cell activity.

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Effects of human amniotic fluid on peritendinous adhesion formation and tendon healing after flexor tendon surgery in rabbits

Cited by 70 publications

References 24 publications

Effects of repetitive injections of hyaluronic acid on peritendinous adhesions after flexor tendon repair: a preliminary randomized, placebo-controlled clinical trial

Effects of repetitive injections of hyaluronic acid on peritendinous adhesions after flexor tendon repair: a preliminary randomized, placebo-controlled clinical trial

Effect of lyophilized amniotic membrane, hyaluronic acid, and their combination in preventing adhesion after tendon repair in New Zealand white rabbits

Preparation of Amniotic Membrane and It’s Application in the Treatment of Skin Loss and Lyell's Syndrome (Toxic Epidermal Necrolysis): Current State and New Opportunities

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