Effects of Human Amniotic Fluid on Fracture Healing in Rat Tibia

Effects of leptin on fracture healing in rat tibia

“…[13] Fracture healing studies in the literature have been increasing in frequency. [14][15][16][17] Fracture healing including interaction between cells, growth factors, and extracellular matrix is a wound healing process which summarizes skeletal growth and development. Inflammatory cells, vascular cells, osteochondral progenitor cells and osteoclasts play an important role at the cellular level of the repair process.…”

“…When we compared histological results with similar studies in the literature, the control group was found to be compatible with the literature. [16,17] The weaknesses of the study include our not determining leptin concentrations in serum, and not performing biomechanical testing of the callus.…”

Líquido amniótico tópico: uma potencial nova alternativa para doenças da superfície ocular

“…O grupo 1 recebeu sobre as linhas de fratura a instilação de LAH coletado na 18ª semana de gestação; o grupo 2 recebeu sobre as linhas de fratura a instilação de LAH coletado no final da gestação, enquanto o grupo 3 não se aplicou nenhum tratamento (27) . O resultado mostrou que a pontuação de cura da fratura foi maior no grupo 1 radiologicamente na terceira e quinta semanas pós-operatórios (p<0,037, p=0,018 respectivamente).…”

The effect of human amniotic fluid on mandibular distraction osteogenesis

“…FGF has angiogenic properties and mitogenic activity on the osteoblast lineage. 12 A rich content of growth and trophic factors such as epidermal growth factor (EGF), FGF, and insulin-like growth factors I and II (IGF-I and IGF-II), which are critical for development, have been identified in human amniotic fluid (HAF). [12][13][14][15] Additionally, hyaluronic acid (HA), hyaluronic acid stimulating activator (HASA), chondroitin-4-and -6-sulphate, dermatan sulphate, and heparan sulphate have been identified in HAF.…”

“…12 A rich content of growth and trophic factors such as epidermal growth factor (EGF), FGF, and insulin-like growth factors I and II (IGF-I and IGF-II), which are critical for development, have been identified in human amniotic fluid (HAF). [12][13][14][15] Additionally, hyaluronic acid (HA), hyaluronic acid stimulating activator (HASA), chondroitin-4-and -6-sulphate, dermatan sulphate, and heparan sulphate have been identified in HAF. 12,16 HAF, generally obtained by amniocentesis during the second trimester of gestation, contains high molecular weight HA and HASA in high concentrations.…”