Effects of Hormone Administration on Serum Protein Patterns.

Hoch-Ligeti, Cornelia; Irvine, Karen

doi:10.3181/00379727-87-21369

Cited by 12 publications

(4 citation statements)

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“…Feigelson et al (24) reported maximum incorporation of 2-14C-glycine into rat liver protein occurring approximately 4 hr after cortisone administration. Aschkenasy (15) and Hoch-Ligeti and Irvine (14) reported rises in serum albumin following glucocorticoid administration. White et al (22) indicated that plasma albumin synthesis appears to be limited to the liver.…”

Section: Discussionmentioning

confidence: 99%

“…The pattern of variability noted in serum free amino acids and urea nitrogen in the intact triglyceride-fed rats would seem to be indicative of amino acid metabolism and gluconeogenesis. Glucocorticoids have been shown to elevate both the serum total protein and albumin concentrations (14,15). Thus, the effect of oil ingestion upon serum total protein and albumin was studied (Table III).…”

Section: R Esu Ltsmentioning

confidence: 99%

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Corticoid release and gluconeogenesis following triglyceride ingestion in the rat

Lenz

Wien

Fleischman

1970

Lipids

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Following a 5.0 ml triglyceride (cottonseed oil) gavage, there was a 60% elevation in the blood glucose concentration by the seventh hour in naturally occurring hypertriglyceridemic rats of the Long Evans strain. Glycogenolysis from liver or gastrocnemius muscle glycogen did not seem to be the source of this glucose. A significant elevation in the plasma total amino acid concentration concomitant with a peak in the blood urea nitrogen concentration by the fifth hour after gavage implicated gluconeogenesis. A prolonged plasma total corticoid elevation from hours 1 1/2 through 3 post‐ingestion, which did not occur in non‐fed or mineral oil‐fed cohorts, supported gluconeogenesis. The serum total protein concentration rose significantly and progressively to a peak by the eighth hour due to an elevation in the albumin concentration. These elevations in serum proteins appeared to support glucocorticoid mediated gluconeogenesis. Adrenalectomy appeared to negate triglyceride‐induced elevation in serum free amino acids, urea nitrogen, total protein and albumin.

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Section: Discussionmentioning

confidence: 99%

Section: R Esu Ltsmentioning

confidence: 99%

Corticoid release and gluconeogenesis following triglyceride ingestion in the rat

Lenz

Wien

Fleischman

1970

Lipids

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“…It is possible that glycoproteins are synthesised directly by the tumour, but in view of the diversity of protein changes, it seems more likely that the malignant process is indirectly affecting the metabolism of these proteins. Their synthesis in the liver is known to be influenced by many hormones (Hoch-Ligeti and Irvine, 1954;Good et al, 1971) and we are currently investigating the relationship of hormone and protein changes in our cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Serum protein changes in breast cancer: a prospective study.

Pettingale¹,

Tee²

1977

J Clin Pathol

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SUMMARY Sixty women admitted to the King's College Hospital group for biopsy of a lump in the breast have been followed sequentially for one year. Thirty women had early operable breast cancer and 30 had benign breast disease. Each patient had 10 serum proteins measured preoperatively and postoperatively at three months and at one year. The patients with breast cancer had significantly higher levels of 2 glycoprotein preoperatively and caeruloplasmin at one year postoperatively than those with benign breast disease. There were a number of significant correlations between serum protein levels and the progression of breast cancer as measured by the clinical score. There were significant correlations with caeruloplasmin preoperatively and at three months postoperatively.Prealbumin and haemopexin showed correlations preoperatively;°x l antitrypsin and ,B; glycoprotein only correlated at three months postoperatively. A longer follow-up will be required to establish the value of serum protein changes which could predict the development of metastases in patients with breast cancer.

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“…Our (35)(36)(37). It is known that the concentration of a number of serum components increases during pregnancy or estrogen administration; these include fibrinogen, al-, a2-, and p-globulins (38)(39)(40)(41)(42), ceruloplasmin (43), transcortin (44), and the thyroxine-binding a-globulin of serum (45,46). Also, the serum copper level may rise during pregnancy (19)(20)(21)(22)(23)47) or estrogen administration (24,25,43,48 Although the administration of estrogen to patients with Wilson's disease may in some instances result in increase in the serum concentration of copper and ceruloplasmin, it is not usually of therapeutic value.…”

Section: Methodsmentioning

confidence: 99%