Effects of histamine on Th1/Th2 cytokine balance

Cissampelos sympodialis Eichl. (Menispermaceae) inhibits anaphylactic shock reaction in murine allergic model

“…Our data suggest that the intraperitoneal AFL administration may have an anti-allergic activity through the decrease of IgE production. Th2 lymphocytes and its cytokines have a pivotal role in immediate allergic response (Packard;Khan, 2003). The inhibitory effect in the IgE production observed here could be for instance the result of an effect at the levels of cytokine production.…”

The effects of nitric oxide on the immune system during Trypanosoma cruzi infection

“…Interestingly, NO sigInterestingly, NO significantly increases the proliferation, division and viability of regulatory T cells (Sakaguchi 2004), a lymphocyte subset which has been shown to be involved in acute experimental T. cruzi infection ). Indeed, regulatory T cells induced by NO stimulation (NO-Treg) are as efficient as natural Tregs in suppressing the differentiation of different effector lymphocyte subsets (Niedbala et al 1999, Packard & Khan 2003. Furthermore, exposure of murine lymphocytes to NO suppresses IL-2 transcription, reducing clonal expansion and indirectly favouring a Th2 response (TaylorRobinson et al 1994).…”

Anti-asthmatic potential of chrysin on ovalbumin-induced bronchoalveolar hyperresponsiveness in rats

“…Eosinophils, lymphocytes, alveolar macrophages and to the lesser extent neutrophils are infiltrated due to OVA challenge, which are responsible for more sustained inflammatory or latephase response together with alveolar epithelial cells, bronchial epithelial cells and endothelial cells (Rogerio et al, 2007). An imbalance in the Th1/Th2 ratio is reported to be responsible for allergic asthma and there is an increase in the number of Th2 cells and, while Th1 cells are found to be decreased (Packard Khan, 2003). GATA-3 and c-Maf are selective transcription factors (Epstein, 2006) involved in Th2 differentiation, and cytokine production was reported to increase during asthmatic exacerbation .…”