Effects of high‐mobility group box 1 on the proliferation and odontoblastic differentiation of human dental pulp cells

Qi, Shengcai; Cui, Chenchen; Yan, Yun; Sun, Gang; Zhu, Shan

doi:10.1111/iej.12112

Cited by 17 publications

(19 citation statements)

References 31 publications

(59 reference statements)

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“…Some studies have reported that HMGB1 participates in osteochondrogenic differentiation of certain cell types. Qi and his colleagues revealed that during human dental pulp cell (hDPC) odontoblastic differentiation, HMGB1 is translocated from the nucleus to the cytoplasm and then secreted into the extracellular space, promoting hDPC proliferation and mineralized nodule formation [61]. Similar results were observed in human periodontal ligament cells, which have been shown to undergo proliferation, migration, osteogenic differentiation, and biomineralization when exposed to HMGB1 [61].…”

Section: Possible Mechanisms By Which Hmgb1 Promotes Cardiovascular Cmentioning

confidence: 86%

“…Qi and his colleagues revealed that during human dental pulp cell (hDPC) odontoblastic differentiation, HMGB1 is translocated from the nucleus to the cytoplasm and then secreted into the extracellular space, promoting hDPC proliferation and mineralized nodule formation [61]. Similar results were observed in human periodontal ligament cells, which have been shown to undergo proliferation, migration, osteogenic differentiation, and biomineralization when exposed to HMGB1 [61]. Recently, it was demonstrated that HMGB1 can trigger the differentiation of mesenchymal stem cells into osteoblasts, which may provide a theoretical basis for improving clinical treatments for fractures [63, 64].…”

Section: Possible Mechanisms By Which Hmgb1 Promotes Cardiovascular Cmentioning

confidence: 99%

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Roles of High Mobility Group Box 1 in Cardiovascular Calcification

Chen¹,

Wang²,

Chen³

et al. 2017

Cell Physiol Biochem

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Calcific disease of the cardiovascular system, including atherosclerotic calcification, medial calcification in diabetes and calcific aortic valve disease, is an important risk factor for many adverse cardiovascular events such as ischemic cardiac events and subsequent mortality. Although cardiovascular calcification has long been considered to be a passive degenerative occurrence, it is now recognized as an active and highly regulated process that involves osteochondrogenic differentiation, apoptosis and extracellular vesicle release. Nonetheless, despite numerous studies on the pathogenesis of cardiovascular calcification, the underlying mechanisms remain poorly understood. High mobility group box 1 (HMGB1), a nuclear protein bound to chromatin in almost all eukaryotic cells, acts as a damage-associated molecular pattern (DAMP) when released into the extracellular space upon cell activation, injury or death. Moreover, HMGB1 also functions as a bone-active cytokine participating in bone remodeling and ectopic calcification pathogenesis. However, studies on the roles of HMGB1 in promoting cardiovascular calcification are limited to date, and the mechanisms involved are still unclear. In this review, we summarize recent studies investigating the mechanism of cardiovascular calcification and discuss multiple roles of HMGB1 in its development.

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Section: Possible Mechanisms By Which Hmgb1 Promotes Cardiovascular Cmentioning

confidence: 86%

Section: Possible Mechanisms By Which Hmgb1 Promotes Cardiovascular Cmentioning

confidence: 99%

Roles of High Mobility Group Box 1 in Cardiovascular Calcification

Chen¹,

Wang²,

Chen³

et al. 2017

Cell Physiol Biochem

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“…It is therefore reasonable to speculate that during dental pulp injury, locally produced HMGB1 induces cell migration to the injured site and contributes to wound healing, but excessive HMGB1 may cause amplification of inflammation cascade and eventually leading to tissue damage. In addition, a recent study showed HMGB1 promoted odontoblastic differentiation of DPCs, which also indicates the potential of HMGB1 in dental pulp regeneration [30]. Further investigations are needed to elucidate the underlying mechanism of HMGB1 in inflammation and tissue repair and its therapeutic potential in dental pulp regeneration.…”

Section: Discussionmentioning

confidence: 98%

Expression of high mobility group box 1 in inflamed dental pulp and its chemotactic effect on dental pulp cells

Zhang

Jiang

Gong

et al. 2014

Biochemical and Biophysical Research Communications

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“…Previous studies have presented evidence of the impact of HMGB1 during bone repair and remodelling, and the data have demonstrated that HMGB1 induces the secretion of matrix vesicles by macrophages to enhance mineralization, cell proliferation, and cell migration. In addition, HMGB1 increases osteogenic differentiation and exerts an effect on bone resorption .…”

mentioning

confidence: 99%

Stress overload‐induced periodontal remodelling coupled with changes in high mobility group protein B1 during tooth movement: an in‐vivo study

Zou

Lin

2019

European J Oral Sciences

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High mobility group protein B1 (HMGB1), a bone‐active cytokine and an osteocyte alarmin, might have dual functions in bone metabolism that could benefit bone formation and accelerate osteoclastogenic activity. High mobility group protein B1 was recently shown to be involved in tooth movement. Here, we investigated the expression of HMGB1, which remains poorly elucidated, under stress overload‐induced periodontal remodelling conditions in vivo. Thirty‐six Sprague‐Dawley rats (male, 180–200 g) were randomly divided into three groups: two experimental groups, in which 50 or 100 g of force was applied to the first molars for 7 d to induce movement; and one control group, in which no force was applied. These stresses induced tooth movement over significantly different distances, and marked morphological changes were consistently observed in the periodontal tissues of the experimental rats, as demonstrated by histological staining. A real‐time PCR analysis showed upregulation of the receptor activator of nuclear factor‐kappaB ligand‐to‐osteoprotegerin ratio and downregulation of the Hmgb1 gene. Changes in both location and expression of the HMGB1 were observed through immunofluorescence analysis. Our data suggest that HMGB1 expression during orthodontic tooth movement might be regulated in a time‐ and force‐dependent manner that is substantially more complex than anticipated.

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Effects of high‐mobility group box 1 on the proliferation and odontoblastic differentiation of human dental pulp cells

Abstract: HMGB1 promoted the proliferation and odontoblastic differentiation of hDPCs.

Cited by 17 publications

References 31 publications

Roles of High Mobility Group Box 1 in Cardiovascular Calcification

Roles of High Mobility Group Box 1 in Cardiovascular Calcification

Expression of high mobility group box 1 in inflamed dental pulp and its chemotactic effect on dental pulp cells

Stress overload‐induced periodontal remodelling coupled with changes in high mobility group protein B1 during tooth movement: an in‐vivo study

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