Effects of high-dose simvastatin on adrenal and gonadal steroidogenesis in men with hypercholesterolemia

Dobs, Adrian S.; Schrott, Helmut G.; Davidson, Michael; Bays, Harold; Stein, Evan A.; Kush, D.; Wu, Mei; Mitchel, Yale; Illingworth, Roger

doi:10.1053/meta.2000.7716a

Cited by 98 publications

(61 citation statements)

References 23 publications

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“…Besides impairing the availability of the substrate cholesterol, statins also decrease the expression of several key enzymes involved in testosterone production including P450scc, P450c17, and 3βHSD as demonstrated in adrenocortical cells 146,147 , and similar findings have been observed in ovarian cells 148 . It has been established previously that oxidative stress increases the expression of these same steroidogenic enzymes in the ovary 111 .…”

Section: Evidence For Statin Actions In Vitrosupporting

confidence: 57%

Statins in the Treatment of Polycystic Ovary Syndrome

Kodaman

Dulęba²

2008

Semin Reprod Med

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Many women of reproductive age are affected by polycystic ovary syndrome (PCOS), a heterogeneous endocrinopathy characterized by androgen excess, chronic oligo-anovulation and/or polycystic ovarian morphology. In addition, PCOS is often associated with insulin resistance, systemic inflammation and oxidative stress which, on one hand, lead to endothelial dysfunction and dyslipidemia with subsequent cardiovascular sequelae and, on the other hand, to hyperplasia of the ovarian theca compartment with resultant hyperandrogenism and anovulation. While traditionally statins have been used to treat dyslipidemia by blocking HMG-CoA reductase, the rate limiting step in cholesterol biosynthesis; in fact, they possess pleiotropic actions, resulting in antioxidant, antiinflammatory and anti-proliferative effects. Statins offer a novel therapeutic approach to PCOS in that they address the dyslipidemia associated with the syndrome, as well as hyperandrogenism/ hyperandrogenemia. These actions may be due to an inhibition of the effects of systemic inflammation and insulin resistance/hyperinsulinemia. Evidence to date, both in vitro and in vivo, suggests that statins have potential in the treatment of PCOS; however, further clinical trials are needed before they can be considered a standard of care in the medical management of this common endocrinopathy.

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Section: Evidence For Statin Actions In Vitrosupporting

confidence: 57%

Statins in the Treatment of Polycystic Ovary Syndrome

Kodaman

Dulęba²

2008

Semin Reprod Med

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“…four times higher than the dose we used in our study. The study showed a significant reduction in total testosterone levels in the group receiving statins compared to the placebo group [3]. Simvastatin taken in a lower dose, 20 mg/day, for 12 weeks also reduced total testosterone levels compared to the group of patients with hypercholesterolaemia receiving placebo [4].…”

Section: Statins and Testosteronementioning

confidence: 89%

“…The effects of treatment with statins on sex hormone levels have been addressed in multiple publications, but the results of these studies are equivocal [2][3][4][5][8][9][10][11][12].…”

Section: Statins and Total Testosterone Levelsmentioning

confidence: 99%

“…Two double-blind studies investigating the effect of statin treatment on total testosterone levels have been published, a study by Dobs et al and a study by Hyyppa et al, both having been conducted in patients with hypercholesterolaemia without other co-morbidities [3,4]. A total of 81 patients participated in the study by Dobs et al, including 39 men receiving placebo and 41 men being treated by simvastatin for 12 weeks at the dose of 80 mg/day, i.e.…”

Section: Statins and Testosteronementioning

confidence: 99%

“…So it is reasonable to hypothesise that the use of statins may suppress steroidogenesis [2][3][4][5][6]. A certain role may also be played by other mechanisms of action identified in the case of statins, such as the inhibition of 17-hydroxysteroid dehydrogenase activity (simvastatin) [1,7].…”

Section: Introductionmentioning

confidence: 99%

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Terapia z wykorzystaniem statyn a stężenie testosteronu u mężczyzn

Mędraś

Kubicka

Jóźków

et al. 2015

Endokrynologia Polska

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Introduction: Statins belong to the most commonly used medicines worldwide. They affect cholesterol synthesis and thus they may suppress steroidogenesis. Our aim was to evaluate whether the use of statins is associated with the concentration of sex hormones. Material and methods/Results: In a population sample of men (n = 237) we found that subjects receiving statins had significantly lower concentrations of: total testosterone (14.9 vs. 16.35 nmol/L, p = 0.008 after correction for body mass), free testosterone (32 vs. 39 pmol/L, p = 0.004), calculated free testosterone (0.32 vs. 0.36 nmol/L, p < 0.001) and bioavailable testosterone (6.10 vs. 7.56 nmol/L, p < 0.001) than age-matched controls. Conclusions:We conclude that the use of statins may have an impact on the diagnosis of age-related testosterone deficiency in men.

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