Effects of high altitude and sea level on mean platelet volume and platelet count in patients with acute coronary syndrome

Alper, Ahmet Taha; Sevimli, Serdar; Hasdemir, Hakan; Nurkalem, Zekeriya; Güvenç, Tolga Sinan; Akyol, Ahmet; Çakmak, Nazmiye; Durmuş, Gündüz; Gürkan, Kadir

doi:10.1007/s11239-007-0159-9

Cited by 16 publications

(8 citation statements)

References 29 publications

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“…Furthermore, Sharma found there was no significant difference in PLT counts when 50 subjects were moved from low altitude to 3650 m [29]. These results may be explained by the fact that PLT function may be influenced by physiological changes that occur during adaptation to HA, such as increase of aggregation and adhesion of PLT, but not PLT count [19,21,30]. In addition, the factors which can affect the functions of RBC and PLT, such as 2,3-diphosphoglycerate (2,3-DPG) can facilitate O 2 release from hemoglobin, meanwhile, 2,3-DPG inhibits PLT aggregation, but it not change HGB concentration, HCT, and count of PLT [21,31].…”

Section: Discussionmentioning

confidence: 92%

Correlation between RBC changes and coagulation parameters in high altitude population

Zhang

Yu²,

Shen³

et al. 2019

Hematology

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Objective: To explore the correlations between RBCs indexes and the basic coagulation parameters, and provide data for further studies on high altitude-induced thrombotic disease. Methods: A total of eligible 433 volunteers were divided into different groups according to HGB concentration and HCT, respectively. PT, APTT, TT and Fbg were measured by clotting assays. HGB content, HCT and PLT count were assessed by automated hematology analyzer. Results: APTT and PT were significantly higher in group 4 (high HGB or HCT groups) (p < 0.05 for all comparison) and PLT count was significantly lower in group 4 than in other groups (p < 0.01 for all comparison). APTT and PT showed negative correlations with HGB concentration (r = −0.168 and −0.165 resp.; both p < 0.01), whereas positive correlations were found between APTT and HCT, PT and HCT (r = 0.225 and 0.258, resp.; both p < 0.01). PLT, TT and Fbg showed no correlation with HGB and HCT. Conclusions: HGB and HCT may not correlate with basic coagulation parameters in high altitude population, their predictive value for high altitude-induced thrombotic disease may relatively independent and this remain to be determined in further studies.

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Section: Discussionmentioning

confidence: 92%

Correlation between RBC changes and coagulation parameters in high altitude population

Zhang

Yu²,

Shen³

et al. 2019

Hematology

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“…This systemic inflammatory state promotes megakaryocytes (especially interleukin 3 and 6) to produce platelets (15). An increase in MPV is seen, which indicates that thrombocytes that are both metabolically and enzymatically more active than smaller ones, because large thrombocytes have more dense granules containing more thromboxane A2 (3,4). However, MPV is not paid enough attention by most clinicians; determination of MPV is a cheap, readily available, and reliable method of assessing platelet functions and is automatically calculated by hematology analyzers.…”

Section: Discussionmentioning

confidence: 99%

“…Larger platelets have more thromboxane A2-containing dense granules, which are associated with higher activity (3,4). Increased MPV is associated with a variety of conditions and diseases such as smoking, diabetes, ischemic coronary diseases, and thromboembolism.…”

Section: Introductionmentioning

confidence: 99%

Effects of intraabdominal pressure on mean platelet volume during laparoscopic cholecystectomy

Celep¹,

Kahramanca²,

Özsoy³

et al. 2014

Turk J Med Sci

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In this study, the effects of organic silicon (Si) on the toxicity of imidacloprid to a new invasive mealybug, Phenacoccus solenopsis (Hemiptera: Pseudococcidae), infesting Portulaca grandiflora (Caryophyllales: Portulacaceae) plants were evaluated using spotting and dipping methods under laboratory and field conditions to improve management strategies for solenopsis mealybug. Results showed significant synergistic effects of 0.06% organic Si with imidacloprid solution against third-instar P. solenopsis nymphs and adult females. However, the percentage mortalities increased remarkably after P. solenopsis was exposed to 100, 50, and 25 mg a.i./L of imidacloprid combined with organic Si. For the third-instar nymphs, these values increased to 100%, 100%, and 92.5%, respectively; for the adult females, these values increased to 100%, 100%, and 82.4%, respectively. After 5 days, the percentage mortalities reached 84.7%, 56.1%, and 39.7% when the third-instar nymphs were exposed to 100, 50, and 25 mg a.i./L of imidacloprid solution, respectively. The percentage mortalities reached 57.5%, 38.9%, and 26.2% when adult females were exposed to the same imidacloprid solutions, respectively. Organic Si alone elicited toxicity to P. solenopsis. The percentage mortalities of the first-, second-, and third-instar nymphs and the adult females were 76.9%, 47.5%, 39.2%, and 18.9%, respectively. Field data showed that imidacloprid combined with organic Si caused sustainable control of P. solenopsis. The percentage mortalities of P. solenopsis reached maximum values (approximately 99.9%) after 21 days. Thus, the combined treatment with imidacloprid and organic Si is synergistically more effective than the individual use of these substances against third-instar P. solenopsis nymphs and adult females.

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“…At approximately 4,400 feet above sea level, Northern Nevada, where this study is conducted, is considered a high desert in the Sierra Nevada foothills. Alper showed that mean platelet volume (MPV) is 7.5% higher at altitudes greater than 4,000 feet than at sea level [14]. Similarly, Hudson showed a notable and statistically significant positive correlation with platelet counts (PC) and altitude [15], while mean corpuscular volume (MCV) was recorded as lower at higher altitudes than at sea level [16].…”

Section: Introductionmentioning

confidence: 99%

GWAS and PheWAS of red blood cell components in a Northern Nevadan cohort

et al. 2019

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In this study, we perform a full genome-wide association study (GWAS) to identify statistically significantly associated single nucleotide polymorphisms (SNPs) with three red blood cell (RBC) components and follow it with two independent PheWASs to examine associations between phenotypic data (case-control status of diagnoses or disease), significant SNPs, and RBC component levels. We first identified associations between the three RBC components: mean platelet volume (MPV), mean corpuscular volume (MCV), and platelet counts (PC), and the genotypes of approximately 500,000 SNPs on the Illumina Infimum DNA Human OmniExpress-24 BeadChip using a single cohort of 4,673 Northern Nevadans. Twenty-one SNPs in five major genomic regions were found to be statistically significantly associated with MPV, two regions with MCV, and one region with PC, with p <5x10 -8 . Twenty-nine SNPs and nine chromosomal regions were identified in 30 previous GWASs, with effect sizes of similar magnitude and direction as found in our cohort. The two strongest associations were SNP rs1354034 with MPV ( p = 2.4x10 -13 ) and rs855791 with MCV ( p = 5.2x10 -12 ). We then examined possible associations between these significant SNPs and incidence of 1,488 phenotype groups mapped from International Classification of Disease version 9 and 10 (ICD9 and ICD10) codes collected in the extensive electronic health record (EHR) database associated with Healthy Nevada Project consented participants. Further leveraging data collected in the EHR, we performed an additional PheWAS to identify associations between continuous red blood cell (RBC) component measures and incidence of specific diagnoses. The first PheWAS illuminated whether SNPs associated with RBC components in our cohort were linked with other hematologic phenotypic diagnoses or diagnoses of other nature. Although no SNPs from our GWAS were identified as strongly associated to other phenotypic components, a number of associations were identified with p -values ranging between 1x10 -3 and 1x10 -4 with traits such as respiratory failure, sleep disorders, hypoglycemia, hyperglyceridemia, GERD and IBS. The second PheWAS examined possible phenotypic predictors of abnormal RBC component measures: a number of hematologic phenotypes such as thrombocytopenia, anemias, hemoglobinopathies and pancytopenia were found to be strongly associated to RBC component measures; additional phenotypes such as (morbid) obesity, malaise and fatigue, alcoholism, and cirrhosis were also identified to be possible predictors of RBC component measures.

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Effects of high altitude and sea level on mean platelet volume and platelet count in patients with acute coronary syndrome

Cited by 16 publications

References 29 publications

Correlation between RBC changes and coagulation parameters in high altitude population

Correlation between RBC changes and coagulation parameters in high altitude population

Effects of intraabdominal pressure on mean platelet volume during laparoscopic cholecystectomy

GWAS and PheWAS of red blood cell components in a Northern Nevadan cohort

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