Correlation between RBC changes and coagulation parameters in high altitude population

Zhang, Rong; Yu, Xiaochuan; Shen, Yuanzhen; Yang, Chunhui; Liu, Fengjuan; Ye, Shengliang; Du, Xi; Ma, Li; Cao, Haijun; Wang, Zongkui; Li, Changqing

doi:10.1080/16078454.2019.1568658

Cited by 19 publications

(15 citation statements)

References 29 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our previous proteomic studies also displayed that plasma proteomics profiles significantly altered between high altitude polycythemia (HAPC) patients and HA healthy controls [14], and between HA and LA participants [15]. Moreover, we found that, in HA participants, prothrombin time (PT) and activated partial thromboplastin time (APTT) negatively correlated with hemoglobin (HGB) concentrations [26].…”

Section: Introductionmentioning

confidence: 77%

See 1 more Smart Citation

Effects of long-term high-altitude exposure on fibrinolytic system

Jiang

Wang

Yu³

et al. 2021

Hematology

Self Cite

View full text Add to dashboard Cite

Objective: High altitude (HA), with the main feature of hypobaric hypoxia, is an independent risk factor for thrombosis. However, little is known on the alterations of fibrinolytic system in adaptation to HA. In this study, we investigated changes of fibrinolytic system parameters between individuals permanently living at HA and low altitude (LA) regions, and provided data for further studies on HA-induced thrombotic disease. Material and methods: A total of 226 eligible participants, including 103 LA participants, 100 healthy HA subjects and 23 high altitude polycythemia (HAPC) patients, were recruited in this study. Six fibrinolytic parameters, i.e. fibrinogen (Fbg), D-dimer (DDi), antithrombin III (AT-III), plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA) and plasminogen (PLG) were analyzed respectively. PAI-1 and tPA were performed by using bioimmuno-assays and an automated coagulation analyzer was used to conduct Fbg, DDi, AT-III and PLG tests. Results: Plasma levels of Fbg, DDi, PAI-1 and PLG were significantly higher in healthy HA group than in LA group (all p < 0.05), whereas tPA was significantly lower in healthy HA group. No significant difference in AT-III was observed between healthy HA and LA groups (p > 0.05). All these fibrinolytic parameters showed no significant distinctions between healthy HA subjects and HAPC patients (all p > 0.05). HGB showed no relationship with fibrinolytic parameters in HA cohort. Conclusion:This study demonstrates that HA environment has a significant effect on fibrinolytic system and provides a foundation for further studies on HA hypobaric hypoxiainduced thrombotic disease.

show abstract

Section: Introductionmentioning

confidence: 77%

“…Blood specimens were collected and prepared as we previously described [14,15,[25][26][27]. Briefly, two tubes of blood sample of each participant (∼5 mL/tube) were drawn by venipuncture.…”

Section: Sample Preparationmentioning

confidence: 99%

Effects of long-term high-altitude exposure on fibrinolytic system

Jiang

Wang

Yu³

et al. 2021

Hematology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Wu et al [10] reported that the HGB levels of normal Tibetan females ranged from 134 to 157 g/L and those of males ranged from 134 to 147 g/L, depending on the altitude. Zhang et al [11] divided WB samples of Tibetan volunteers into 4 groups according to different HGB values, which could be >184 or <166 g/L. Our team previously reported that the WB of Tibetan males had a HGB level of 165.62 g/L [12].…”

Section: Introductionmentioning

confidence: 99%

An Evaluation of Morphological Changes and Deformability of Suspended Red Blood Cells Prepared Using Whole Blood with Different Hemoglobin Levels of Tibetans

Zhong¹,

Han²,

et al. 2021

Transfus Med Hemother

View full text Add to dashboard Cite

Background: The hypoxic environment stimulates the human body to increase the levels of hemoglobin (HGB) and hematocrit and the number of red blood cells. Such enhancements have individual differences, leading to a wide range of HGB in Tibetans’ whole blood (WB). Study Design: WB of male Tibetans was divided into 3 groups according to different HGB (i.e., A: >120 but ≤185 g/L, B: >185 but ≤210 g/L, and C: >210 g/L). Suspended red blood cells (SRBC) processed by collected WB and stored in standard conditions were examined aseptically on days 1, 14, 21, and 35 after storage. The routine biochemical indexes, deformability, cell morphology, and membrane proteins were tested. Results: Mean corpuscular volume, adenosine triphosphate, pH, and deformability were not different in group A vs. those in storage (p > 0.05). The increased rate of irreversible morphology of red blood cells was different among the 3 groups, but there was no difference in the percentage of red blood cells with an irreversible morphology after 35 days of storage. Group C performed better in terms of osmotic fragility and showed a lower rigid index than group A. Furthermore, SDS-PAGE revealed similar cross-linking degrees of cell membrane protein but the band 3 protein of group C seemed to experience weaker clustering than that of group A as detected by Western Blot analysis after 35 days of storage. Conclusions: There was no difference in deformability or morphological changes in the 3 groups over the 35 days of storage. High HGB levels of plateau SRBC did not accelerate the RBC change from a biconcave disc into a spherical shape and it did not cause a reduction in deformability during 35 days of preservation in bank conditions.

show abstract

“…PLT is another factor playing a key role in thrombogenesis. Previous studies showed different effects of high-altitude exposure on PLT count ( 29 ). The result of this study is consistent with most of the other studies indicating that PLT counts were lower in plateau areas than in plain areas ( 23 , 29 – 31 ).…”

Section: Discussionmentioning

confidence: 99%

The Clinical Differences of Patients With Traumatic Brain Injury in Plateau and Plain Areas

Yang¹,

Peng

He³

et al. 2022

Front. Neurol.

View full text Add to dashboard Cite

ObjectiveTraumatic brain injury (TBI) is a leading cause of death and disability, which tends to have a worse clinical recovery if it occurs in plateau areas than in plain areas. To explore the underlying cause of this outcome preliminarily, this retrospective study was conducted to compare the clinical differences of patients with TBI in plateau and plain areas.MethodsIn this study, 32 patients with TBI in plateau areas (altitude ≥ 4,000 m) and 32 in plain areas (altitude ≤ 1,000 m) were recruited according to the inclusion and exclusion criteria from June 2020 to December 2021. The collected data and compared parameters include clinical features, head CT presentations and Marshall classifications, hematology profile, lipid profile, coagulation profile, and multiorgan (cardiac, liver, renal) function within 24 h of hospital admission, as well as the treatment method and final outcome.ResultsThere were no obvious differences in demographic characteristics, including gender, age, height, and weight, between patients with TBI in plateau and plain areas (all P > 0.05). Compared to patients with TBI in plain areas, the time before hospital admission was longer, heartbeat was slower, systolic blood pressure (SBP) was lower, and hospital stays were longer in patients with TBI in plateau areas (all P < 0.05). More importantly, elevated red blood cells (RBCs) count and hemoglobin (HGB) level, enhanced coagulation function, and higher rates of multiorgan (cardiac, liver, and renal) injury were found in patients with TBI in plateau areas (all P < 0.05).ConclusionPatients with TBI in plateau areas presented with altered clinical characteristics, enhanced coagulation function, and aggravated predisposition toward multiorgan (cardiac, liver, and renal) injury, compared to patients with TBI in plain areas. Future prospective studies are needed to further elucidate the influences of high altitude on the disease course of TBI.

show abstract

Correlation between RBC changes and coagulation parameters in high altitude population

Cited by 19 publications

References 29 publications

Effects of long-term high-altitude exposure on fibrinolytic system

Effects of long-term high-altitude exposure on fibrinolytic system

An Evaluation of Morphological Changes and Deformability of Suspended Red Blood Cells Prepared Using Whole Blood with Different Hemoglobin Levels of Tibetans

The Clinical Differences of Patients With Traumatic Brain Injury in Plateau and Plain Areas

Contact Info

Product

Resources

About