Effects of herpes simplex virus on human oral cancer cells, and potential use of mutant viruses in therapy of oral cancer

An oncolytic mutant of herpes simplex virus type-1 in which replication is governed by a promoter/enhancer of human papillomavirus type-16

“…8,21,22 However, wild-type HSV-1 has significant side effects when used for this purpose in animal models, with zosteriform rash, viral encephalitis and reduced survival. 5,21 Although no strains of HSV-1 have been designed specifically for the treatment of oral cancer to date, other conditionally replicating strains have been constructed for the treatment of other cancers. One modification that has been made by others is to prevent the function of the gene for ribonucleotide reductase, thus limiting the virus to replicating cells and providing some tumor-specificity.…”

Oral squamous cell carcinoma and cultural oral risk habits in Vietnam

“…The reported aetiological agents and risk factors for oral cancer include tobacco use, frequent alcohol consumption, the use of areca nut, a compromised immune system, a past history of cancer, dietary habits and less well‐established factors such as infection with certain types of human papilloma viruses (5–9). Alarmingly, 25% of newly diagnosed cases of oral cancer do not fit the high‐risk profile (10–12).…”

Clinical and pathological features of the murine AT‐84 orthotopic model of oral cancer

“…For example human cells in nude mice are relevant in that the cells are human, but the animal host is necessarily immunosuppressed, which limits the experiments which are possible. Furthermore, it is not unusual for human tumors grown in nude mice to regress spontaneously (Shillitoe et al , 1999).…”

“…An alternative model, which is popular, is the implantation of human oral cancer cells to immunosuppressed animals. Although this readily induces tumors for further study (Eicher et al , 1996), some human cancers fail to induce a blood supply and regress fairly rapidly (Shillitoe et al , 1999).…”