Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice

Mori, Koichiro; Obara, Yutaro; Moriya, Takuya; Inatomi, Satoshi; Nakahata, Norimichi

doi:10.2220/biomedres.32.67

Cited by 59 publications

(58 citation statements)

References 26 publications

(42 reference statements)

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“…106 Evaluation of the learning function of the mice by behavioral pharmacological methods (Y-maze and novel-object recognition tests) indicates that the mushroom powder improves the cognitive deficits induced by the amyloid peptide, suggesting that the powder might be a promising treatment for cognitive dysfunction. Additional HPLC studies showed that the powder contained the following three hericenones: C, 4.12 mg/g; D, 0.21 mg/g; and E, 0.49 mg/g.…”

Section: ■ Anticarcinogenic Propertiesmentioning

confidence: 99%

Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds

Friedman

2015

J. Agric. Food Chem.

228

164

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The culinary and medicinal mushroom Hericium erinaceus is widely consumed in Asian countries, but apparently not in the United States, for its nutritional and health benefits. To stimulate broader interest in the reported beneficial properties, this overview surveys and consolidates the widely scattered literature on the chemistry (isolation and structural characterization) of polysaccharides and secondary metabolites such as erinacines, hericerins, hericenones, resorcinols, steroids, mono- and diterpenes, and volatile aroma compounds, nutritional composition, food and industrial uses, and exceptional nutritional and health-promoting aspects of H. erinaceus. The reported health-promoting properties of the mushroom fruit bodies, mycelia, and bioactive pure compounds include antibiotic, anticarcinogenic, antidiabetic, antifatigue, antihypertensive, antihyperlipodemic, antisenescence, cardioprotective, hepatoprotective, nephroprotective, and neuroprotective properties and improvement of anxiety, cognitive function, and depression. The described anti-inflammatory, antioxidative, and immunostimulating properties in cells, animals, and humans seem to be responsible for the multiple health-promoting properties. A wide range of research advances and techniques are described and evaluated. The collated information and suggestion for further research might facilitate and guide further studies to optimize the use of the whole mushrooms and about 70 characterized actual and potential bioactive secondary metabolites to help prevent or treat human chronic, cognitive, and neurological diseases.

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Section: ■ Anticarcinogenic Propertiesmentioning

confidence: 99%

Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds

Friedman

2015

J. Agric. Food Chem.

228

164

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“…In traditional Chinese medicine, HE has long been considered a medicinal mushroom, and it was reported that effective compounds such as threitol, β-sitosterol, (1) and pyrone compounds. (2) HE also reported which might have prevention of cognitive dysfunction, (3) modulation of lipid metabolic gene expression, (4) stimulation nerve growth factor synthesis, (5,6) and anti-cancer activity. (7,8) We hypothesized that HE could protect against oxidative damage by scavenging reactive oxygen species (ROS) such as superoxide anion and hydroxyl radicals, and its fraction might be useful for anti-inflammatory effect in RAW 264.7 macrophages.…”

Section: Introductionmentioning

confidence: 97%

Hericium erinaceussuppresses LPS-induced pro-inflammation gene activation in RAW264.7 macrophages

Kim¹,

Lee²,

Oh³

et al. 2011

Immunopharmacology and Immunotoxicology

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The aim of this study was to investigate the anti-inflammatory properties of each fraction of Hericium erinaceus (HE). The ethanol extract from HE was partitioned with different solvents in the order of increasing polarity. The treatment with 10-100 μg/mL of each fraction did not reduce RAW 264.7 cell viability except ethyl acetate fraction. Among the various extracts, the chloroform fraction showed the most potent activity against nitric oxide (NO), prostaglandin E(2) (PGE(2)) and reactive oxygen species (ROS). The western blotting and reverse transcriptase polymerase chain reaction (RT-PCR) analyses revealed that chloroform fraction from HE (CHE) significantly reduced the protein level of iNOS and cyclooxygenase-2 (COX-2) or mRNA levels of iNOS in lipopolysaccharide-induced macrophages. Furthermore, CHE inhibited the translocation of nuclear factor (NF)-κB p65 subunit, phsophorylation of I-κB, extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) in a dose-dependent manner. Furthermore, the activation of both activator protein-1 (AP-1) and NF κB in the nucleus were abrogated by CHE with luciferase assay. In conclusion, these results indicate that CHE may provide an anti-inflammatory effect by attenuating the generation of excessive NO, PGE(2), and ROS and by suppressing the expression of pro-inflammatory genes through the inhibition of NF-κB and JNK activity.

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“…In mice, dietary supplementation with H. erinaceus prevents the impairment of spatial short-term and visual recognition memory induced by amyloid β (25–35) peptide [2]. Recently, Hazekawa et al [3] described the neuroprotective effects of H. erinaceus dietary supplementation in mice subjected to middle cerebral artery occlusion.…”

Section: Introductionmentioning

confidence: 99%

Dietary Supplementation of Hericium erinaceus Increases Mossy Fiber‐CA3 Hippocampal Neurotransmission and Recognition Memory in Wild‐Type Mice

Brandalise

Cesaroni

Gregori³

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Hericium erinaceus (Bull.) Pers. is a medicinal mushroom capable of inducing a large number of modulatory effects on human physiology ranging from the strengthening of the immune system to the improvement of cognitive functions. In mice, dietary supplementation with H. erinaceus prevents the impairment of spatial short-term and visual recognition memory in an Alzheimer model. Intriguingly other neurobiological effects have recently been reported like the effect on neurite outgrowth and differentiation in PC12 cells. Until now no investigations have been conducted to assess the impact of this dietary supplementation on brain function in healthy subjects. Therefore, we have faced the problem by considering the effect on cognitive skills and on hippocampal neurotransmission in wild-type mice. In wild-type mice the oral supplementation with H. erinaceus induces, in behaviour test, a significant improvement in the recognition memory and, in hippocampal slices, an increase in spontaneous and evoked excitatory synaptic current in mossy fiber-CA3 synapse. In conclusion, we have produced a series of findings in support of the concept that H. erinaceus induces a boost effect onto neuronal functions also in nonpathological conditions.

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Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice

Cited by 59 publications

References 26 publications

Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds

Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds

Hericium erinaceussuppresses LPS-induced pro-inflammation gene activation in RAW264.7 macrophages

Dietary Supplementation of Hericium erinaceus Increases Mossy Fiber‐CA3 Hippocampal Neurotransmission and Recognition Memory in Wild‐Type Mice

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