Effects of herbal mixture extracts on obesity in rats fed a high-fat diet

Abstract

The aim of this study was to investigate and compare the effects of three herbal mixture extracts on obesity induced by high-fat diet (HFD) in rats. The prescriptions-Pericarpium citri reticulatae and Fructus crataegi-were used as matrix components and mixed with Ampelopsis grossedentata, Salvia miltiorrhiza, and epigallocatechin-3-gallate (EGCG) to form T1, T2, and T3 complexes, respectively. Results revealed that HFD feeding significantly increased body weight gain, fat deposition, plasma lipid profiles, hepatic lipid accumulation, and hepatic vacuoles formation, but decreased plasma levels of adiponectin in rats. Only the T1 complex showed the tendency, although not significantly so, for decreased HFD-induced body weight gain. T1 and T3 complexes significantly reduced HFD-induced fat deposition, and plasma levels of triglyceride, total cholesterol, and low-density lipoprotein cholesterol. Only the T1 complex significantly increased HFD-reduced adiponectin levels in plasma, but decreased HFD-increased triglyceride content in liver tissues. All complexes effectively inhibited HFD-induced vacuoles formation. The content of dihydromyricetin, salvianolic acid B, and EGCG in T1, T2, and T3 complexes was 18.25 ± 0.07%, 22.20 ± 0.10%, and 18.86 ± 0.04%, respectively. In summary, we demonstrated that herbal mixture extracts, especially T1 complex, exhibit antiobesity activity in HFD-fed rats.

The Effect ofM. latifoliaLeaf Extract on High-Fructose Corn Syrup (HFCS)-Induced Non-alcoholic Fatty Liver Disease in Rat Models

“…Meli et al [41] established that HFD induced hepatic steatosis in mice and rats. In addition, Chien et al [42] reported that HFD feeding significantly increased liver weight, hepatic triglycerides and total cholesterol accumulation and hepatic vacuoles.…”

PEMBERIAN MINYAK IKAN LELE (Clarias gariepinus) TERHADAP BOBOT BADAN DAN PERUBAHAN HISTOPATOLOGI HATI, GINJAL DAN OTAK TIKUS GALUR Sprague dawley YANG DIBERI PAKAN HIPERKOLESTEROLEMIA

“…Hal ini sesuai dengan penelitian yang dilakukan Nikasa et al (2016) yang menunjukkan bahwa diet tinggi kolesterol secara signifikan meningkatkan bobot badan tikus. Beberapa penelitian serupa menunjukkan bahwa tikus yang diberikan pakan tinggi lemak bobot badannya akan meningkat secara signifikan (Davidson et al 2010;Chien et al 2016;Marques et al 2016). Pada minggu ketiga dan keempat mulai diberikan intervensi berdasarkan kelompok perlakuan.…”

“…Srimiati et al (2015) mengatakan bahwa minyak ikan lele mengandung omega 6 dan omega 3 walaupun perbandingan omega 6 lebih tinggi dari omega 3. Hal ini sesuai dengan pernyataan Chen et al (2016) yang menyatakan bahwa pemberian omega 3 dapat meningkatkan steatosis hati dan memperbaiki fungsi hati.…”

Preventive Effects of <i>Ophiocordyceps </i><i>s</i><i>inensis </i>Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice

“…Higher serum AST, ALT, and free fatty acids, as well as liver TC, TG, TBARS, and cytokine levels were easily observed in a HFD fed rodent models [22,27,28]. It has been reported that the hepatoprotection of OSM against CCl 4 resulted in decreased serum AST and ALT values.…”