Effects of Herbal Medicine for Growth of Children: a Retrospective Study

Kim, Ji Eun; Baek, Jung Han

doi:10.7778/jpkm.2016.30.4.087

Cited by 2 publications

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References 1 publication

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“…Considering that there is a social trend for achieving height growth following effective treatments, [ 8 ] there is an increasing desire for conducting studies for evaluating the effectiveness of different materials and treatment methods for addressing growth problems. In this regard, materials derived from deer antlers are of great interest, as they are widely used for immunity enhancement, growth, and development of children.…”

Section: Introductionmentioning

confidence: 99%

The 12 weeks, randomized, double-blinded, placebo-controlled human study to evaluate the effectiveness and safety of KGC deer antlers on the growth of children

et al. 2022

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Background: Cervi parvum cornu is a dried section of the young horns of Cervus nippon Temminck, Cervus elaphus Linnaeus, or Cervus canadensis Erxleben. It is a representative yang-tonifying medicine that warms the viscera and bowels, activates the overall physiological function, and has effects such as tonifying kidney yang, replenishing essence and blood, and strengthening muscles and bones.Objective: This clinical study is aimed to evaluate the effectiveness of deer antler extract on child growth.Methods: This clinical trial is designed to be conducted on 100 children aged 3 to 12 years for 12 weeks (Trial registration code: KCT0007386). We will evaluate changes in height, height percentile, standard deviation score of height, weight, body mass index, waist circumference, hip circumference, bone age, predicted adult height estimated by bone age, human growth hormone level, insulin-like growth factor-1 (IGF-1) level, IGF-binding protein-3 (IGFBP-3) level, IGF-1/IGFBP-3 ratio, and estradiol level. Additionally, we also will evaluate the adverse events during the study.Abbreviations: AE = adverse event, BA = bone age, FAS = full analysis set, GH = growth hormone, IGF-1 = insulin-like growth factor-1, IGFBP-3 = insulin-like growth factor binding protein-3, IRB = Institutional review board, PAH = predicted adult height, SD = standard deviation, SDS = standard deviation score.

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Section: Introductionmentioning

confidence: 99%

The 12 weeks, randomized, double-blinded, placebo-controlled human study to evaluate the effectiveness and safety of KGC deer antlers on the growth of children

et al. 2022

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Clinical Study on Child’s Height Growth of Mixtures of Cynanchum wilfordii and Phlomis umbrosa Extract

Ha¹,

Baek²,

Kim³

et al. 2019

J Korean Med Rehabil

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Objectives Previous animal studies have shown that mixtures of Cynanchum wilfordii and Phlomis umbrosa extract (IPLUS-CWPU) increases femur length and insulin like growth factor-1 (IGF-1) secretion. IPLUS-CWPU may thus be a promising ingredient in functional foods aimed at growing child's height. The purpose of the study is to investigate the effect of IPLUS-CWPU on height growth in children with short stature. Methods For this purpose, we recruited 90 children aged 4 to 12 years who had heights ranging from the 5th to 25th percentiles of Korean children's growth curve and randomized to either the IPLUS-CWPU or the placebo group. Results The IPLUS-CWPU group showed a significant increase in the change of the height growth compared to the placebo group after 20 weeks of administration (p=0.02). The height growth velosity also showed a statistically significant difference in the test group compared to the placebo group at 10 weeks (p=0.04). The IGF-1 levels showed a tendency to increase in the IPLUS-CWPU group (p=0.08). Moreover, the IPLUS-CWPU significantly increased IGF-1/IGFBP-3 ratio (p=0.02). However, there were no significant differences in blood biochemical parameters including growth hormone, bone age, thyroid stimulating hormone, and osteocalcin levels. Conclusions In conclusion, the data of this trial indicate that IPLUS-CWPU is effective and safe, generally well-tolerated without severe adverse events, in the treatment of children with short stature over a 20 weeks period.

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Effects of Herbal Medicine for Growth of Children: a Retrospective Study

Cited by 2 publications

References 1 publication

The 12 weeks, randomized, double-blinded, placebo-controlled human study to evaluate the effectiveness and safety of KGC deer antlers on the growth of children

The 12 weeks, randomized, double-blinded, placebo-controlled human study to evaluate the effectiveness and safety of KGC deer antlers on the growth of children

Clinical Study on Child’s Height Growth of Mixtures of Cynanchum wilfordii and Phlomis umbrosa Extract

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