Effects of heavy ions on visual function and electrophysiology of rodents: the ALTEA-MICE project

Biocompatibility of a Conjugated Polymer Retinal Prosthesis in the Domestic Pig

“…Another important aspect in the field of vision science research is the trophic effect induced by retinal surgery, which could per se enhance photoreceptors' survival. To address this issue, we performed immunohistochemistry for FGF2, a trophic factor constitutively expressed in Muller cells and retinal ganglion cells (Walsh et al, 2001;Valter et al, 2002) whose upregulation and translocation to the ONL in the retina is a typical landmark of photoreceptor stress (Xiao et al, 1998(Xiao et al, , 1999Sannita et al, 2004;Valter et al, 2005;Rutar et al, 2010;Hochmann et al, 2012). An induction of FGF2 levels, likely due to the surgical implantation procedure, was found in the neighboring areas of the retina.…”

Dose- and ApoE Isoform-Dependent Cognitive Injury after Cranial56Fe Irradiation in Female Mice

“…Light flashes were observed by the astronauts during the early Apollo missions and dedicated experiments subsequently performed on later Apollo and Skylab missions (Pinsky et al 1974). More recently, studies of light flashes have been made on the Russian Mir space station and the International Space Station (ISS) (Narici 2008;Sannita et al 2004). A 1973 report by the National Academy of Science considered these effects in detail.…”

Using the human eye to image space radiation or the history and status of the light flash phenomena

“…For example, electrical signals from the retina and visual cortex in mice stimulated by a C 6+ beam are being studied (ALTEA-MICE) [26]. In the ALTEA context, a survey was conducted for the purpose of characterizing LFs based on the subjective experience of a much larger number of astronauts than hitherto [27].…”